Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease.

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...

journal_title：Diabetologia

authors： Agersø H,Jensen LB,Elbrønd B,Rolan P,Zdravkovic M

更新日期：2002-02-01 00:00:00

abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

journal_title：Diabetologia

authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

更新日期：1986-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart is largely unknown. ...

journal_title：Diabetologia

authors： Cannon MV,Silljé HH,Sijbesma JW,Khan MA,Steffensen KR,van Gilst WH,de Boer RA

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:To assess whether self-monitoring of blood glucose (SMBG) is an independent predictor of improved outcome in a community-based cohort of type 2 diabetic patients. MATERIALS AND METHODS:We used longitudinal data from (1) 1,280 type 2 diabetic participants in the observational Fremantle Diabetes Study (F...

journal_title：Diabetologia

authors： Davis WA,Bruce DG,Davis TM

更新日期：2007-03-01 00:00:00

abstract：:To assess in vivo effects of antioxidants on vascular cell adhesion molecule (VCAM)-1 expression, circulating soluble VCAM-1 and intraerythrocytic reduced glutathione (GSH) and GSH disulphide (GSSG) concentrations were evaluated in non-insulin-dependent diabetic patients without complications (9 men, 6 women, 48 +/- 6...

journal_title：Diabetologia

authors： De Mattia G,Bravi MC,Laurenti O,Cassone-Faldetta M,Proietti A,De Luca O,Armiento A,Ferri C

更新日期：1998-11-01 00:00:00

abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

journal_title：Diabetologia

authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

更新日期：2012-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...

journal_title：Diabetologia

authors： Cho YM,Kim TH,Lim S,Choi SH,Shin HD,Lee HK,Park KS,Jang HC

更新日期：2009-02-01 00:00:00

abstract：:The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...

journal_title：Diabetologia

authors： Edmonds ME,Roberts VC,Watkins PJ

更新日期：1982-01-01 00:00:00

abstract：:The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...

journal_title：Diabetologia

authors： Samaja M,Melotti D,Carenini A,Pozza G

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：:Glucose-induced cyclic (3H) AMP accumulation, insulin secretory responses and the metabolism of glucose were studied in pancreatic islets from Acomys cahirinus. 27.7 mmol/l of glucose stimulated neither islet cyclic (3H) AMP accumulation nor insulin release during the first 5 min of incubation. Stimulation by glucose ...

journal_title：Diabetologia

authors： Grill V,Cerasi E

更新日期：1979-01-01 00:00:00

abstract：:A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...

journal_title：Diabetologia

authors： Handberg A,Vaag A,Damsbo P,Beck-Nielsen H,Vinten J

更新日期：1990-10-01 00:00:00

abstract：:Several bariatric operations originally designed to promote weight loss have been found to powerfully treat type 2 diabetes, causing remission in most cases, through diverse mechanisms additional to the secondary consequences of weight loss. These observations have prompted consideration of such operations as 'metabol...

journal_title：Diabetologia

authors： Cummings DE,Rubino F

更新日期：2018-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The 1997 American Diabetes Association classification of diabetes mellitus included a subset of Type I diabetic patients who do not need insulin for several years but eventually progress to complete insulin deficiency i. e. atypical Type I diabetes mellitus. In Caucasian populations, most Type I diabeti...

journal_title：Diabetologia

authors： Lee WJ,Lee HW,Palmer JP,Park KS,Lee HK,Park JY,Hong SK,Lee KU

更新日期：2001-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...

journal_title：Diabetologia

authors： Yu HY,Inoguchi T,Kakimoto M,Nakashima N,Imamura M,Hashimoto T,Umeda F,Nawata H

更新日期：2001-05-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：:46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significa...

journal_title：Diabetologia

authors： Lucas PD

更新日期：1985-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...

journal_title：Diabetologia

authors： Isomaa B,Henricsson M,Almgren P,Tuomi T,Taskinen MR,Groop L

更新日期：2001-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. METHODS:This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance ...

journal_title：Diabetologia

authors： Parkner T,Sørensen LP,Nielsen AR,Fischer CP,Bibby BM,Nielsen S,Pedersen BK,Møller HJ

更新日期：2012-06-01 00:00:00

abstract：:The oscillatory potential of the electroretinogram and the initial 2-min phase of dark-adaptation were studied in seven newly diagnosed Type 1 (insulin-dependent) diabetic patients before and during initial insulin treatment. Strict metabolic control was achieved in all seven patients using multiple subcutaneous injec...

journal_title：Diabetologia

authors： Frost-Larsen K,Christiansen JS,Parving HH

更新日期：1983-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...

journal_title：Diabetologia

authors： Salis MB,Graiani G,Desortes E,Caldwell RB,Madeddu P,Emanueli C

更新日期：2004-06-01 00:00:00

abstract：:Family and twin studies have shown clearly that Type I (insulin-dependent) diabetes mellitus has a genetic basis. However, only within the past decade has it been possible to systematically attempt to identify the genes that increase susceptibility to this disorder using linkage and association analysis of genetic mar...

journal_title：Diabetologia

authors： Field LL

更新日期：2002-01-01 00:00:00

abstract：:Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...

journal_title：Diabetologia

authors： Foulis AK,Farquharson MA,Cameron SO,McGill M,Schönke H,Kandolf R

更新日期：1990-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...

journal_title：Diabetologia

authors： Murphy HR,Elleri D,Allen JM,Harris J,Simmons D,Rayman G,Temple RC,Umpleby AM,Dunger DB,Haidar A,Nodale M,Wilinska ME,Hovorka R

更新日期：2012-02-01 00:00:00

abstract：:Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this approach is, however, scant and few pharmacological agents have proved effective enough to become part of routine clinical care. Recent short-term P...

journal_title：Diabetologia

authors： McCrimmon RJ,Henry RR

更新日期：2018-10-01 00:00:00

abstract：:Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...

journal_title：Diabetologia

authors： Rosenstock J,Loizou SA,Brajkovich IE,Mashiter K,Joplin GF

更新日期：1982-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00