SGLT inhibitor adjunct therapy in type 1 diabetes.

abstract：AIMS/HYPOTHESIS:While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin resistance, we have performed a detailed time-course study in mice fed a high-fat diet (HFD). MET...

journal_title：Diabetologia

authors： Turner N,Kowalski GM,Leslie SJ,Risis S,Yang C,Lee-Young RS,Babb JR,Meikle PJ,Lancaster GI,Henstridge DC,White PJ,Kraegen EW,Marette A,Cooney GJ,Febbraio MA,Bruce CR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Early detection of risk of microalbuminuria could prevent early renal damage. We investigated whether urine retinol binding protein and N-acetyl-glucosaminidase could predict the risk of microalbuminuria in a large cohort of children followed from diagnosis of Type I (insulin-dependent) diabetes mellitu...

journal_title：Diabetologia

authors： Schultz CJ,Dalton RN,Neil HA,Konopelska-Bahu T,Dunger DB,Oxford Regional Prospective Study Group.

更新日期：2001-02-01 00:00:00

abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...

journal_title：Diabetologia

authors： Madsen KL,Ariano D,Fedorak RN

更新日期：1995-04-01 00:00:00

abstract：:A recent investigation of families containing two and three consecutive generations affected with Type I (insulin dependent) diabetes mellitus has led to speculation that there is a second susceptibility gene, not linked to the major histocompatibility complex. These families differ in important respects from families...

journal_title：Diabetologia

authors： Suarez BK,Van Eerdewegh P

更新日期：1981-05-01 00:00:00

abstract：:During the period 1989-1994, 462 cases of insulin-dependent diabetes mellitus were registered among children from Northern Ireland aged under 15 years. The estimated completeness of the register was 98.8% (95% confidence interval (CI) 97.7%, 99.9%). A standardised rate of 19.6 (95% CI 17.8, 21.4) per 100 000 person ye...

journal_title：Diabetologia

authors： Patterson CC,Carson DJ,Hadden DR

更新日期：1996-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is...

journal_title：Diabetologia

authors： Brunner GA,Balent B,Ellmerer M,Schaupp L,Siebenhofer A,Jendle JH,Okikawa J,Pieber TR

更新日期：2001-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...

journal_title：Diabetologia

authors： Sourris KC,Morley AL,Koitka A,Samuel P,Coughlan MT,Penfold SA,Thomas MC,Bierhaus A,Nawroth PP,Yamamoto H,Allen TJ,Walther T,Hussain T,Cooper ME,Forbes JM

更新日期：2010-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

journal_title：Diabetologia

authors： Look AHEAD Research Group.

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

journal_title：Diabetologia

authors： Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

更新日期：2016-11-01 00:00:00

abstract：:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive in...

journal_title：Diabetologia

authors： Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb H

更新日期：1994-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...

journal_title：Diabetologia

authors： Ellard S,Bellanné-Chantelot C,Hattersley AT,European Molecular Genetics Quality Network (EMQN) MODY group.

更新日期：2008-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels with cardiovascular events in patients with type 2 diabetes. METHODS:Plasma FGF21 levels were meas...

journal_title：Diabetologia

authors： Ong KL,Januszewski AS,O'Connell R,Jenkins AJ,Xu A,Sullivan DR,Barter PJ,Hung WT,Scott RS,Taskinen MR,Keech AC,Rye KA

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...

journal_title：Diabetologia

authors： Sansbury FH,Flanagan SE,Houghton JA,Shuixian Shen FL,Al-Senani AM,Habeb AM,Abdullah M,Kariminejad A,Ellard S,Hattersley AT

更新日期：2012-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Interleukin-1beta is a putative mediator of pancreatic beta-cell dysfunction and damage in Type I (insulin-dependent) diabetes mellitus. To better understand the molecular mechanisms involved in IL-1beta effects, we carried out a differential display of mRNA by RT-PCR to identify novel cytokine-regulate...

journal_title：Diabetologia

authors： Chen MC,Schuit F,Eizirik DL

更新日期：1999-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10). METHODS:We studied 203 men of the same age but with varying degr...

journal_title：Diabetologia

authors： Tripathy D,Eriksson KF,Orho-Melander M,Fredriksson J,Ahlqvist G,Groop L

更新日期：2004-05-01 00:00:00

abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

journal_title：Diabetologia

authors： Hutton JC

更新日期：1994-09-01 00:00:00

abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

journal_title：Diabetologia

authors： Masson EA,Veves A,Fernando D,Boulton AJ

更新日期：1989-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...

journal_title：Diabetologia

authors： Okamoto S,Kimura K,Kitamura T,Cañas X,Yoshida T,Saito M

更新日期：2000-12-01 00:00:00

abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

journal_title：Diabetologia

authors： Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

更新日期：1991-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...

journal_title：Diabetologia

authors： Li B,Yu Y,Liu K,Zhang Y,Geng Q,Zhang F,Li Y,Qi J

更新日期：2021-01-01 00:00:00

abstract：:The role of B lymphocytes in the pathogenesis of type 1 diabetes in humans is not entirely evident. These cells are presumed to be important, but this assumption is largely based on animal models of autoimmune diabetes, where compelling evidence for the contribution of both B lymphocytes and insulin-specific autoantib...

journal_title：Diabetologia

authors： Bloem SJ,Roep BO

更新日期：2017-07-01 00:00:00

abstract：:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...

journal_title：Diabetologia

authors： Sasaki A

更新日期：1981-03-01 00:00:00

abstract：:Significant progress has been made in recent years in the characterisation of the signal pathways of beta cell dysfunction and death in the pathogenesis of type 2 diabetes. Glucolipotoxicity acts as an exogenous factor whereas oxidative stress and endoplasmic reticulum stress may result from the processes of signal re...

journal_title：Diabetologia

authors： Rustenbeck I,Baltrusch S,Tiedge M

更新日期：2010-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The process of islet isolation can cause chemical and mechanical injury to beta cells. In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection...

journal_title：Diabetologia

authors： Ahn YB,Xu G,Marselli L,Toschi E,Sharma A,Bonner-Weir S,Sgroi DC,Weir GC

更新日期：2007-02-01 00:00:00

abstract：:Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...

journal_title：Diabetologia

authors： Rasch R

更新日期：1979-05-01 00:00:00

abstract：:Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...

journal_title：Diabetologia

authors： Foulis AK,Farquharson MA,Cameron SO,McGill M,Schönke H,Kandolf R

更新日期：1990-05-01 00:00:00

abstract：:We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...

journal_title：Diabetologia

authors： Plater ME,Ford I,Dent MT,Preston FE,Ward JD

更新日期：1996-03-01 00:00:00