Abstract:
:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive insulitis as seen 8-10 days after cyclophosphamide treatment of 70- to 80-day-old female NOD mice. Immunohistochemistry showed iNOS associated with infiltrating macrophages but not in endocrine cells. The enhancement of iNOS after cyclophosphamide correlated with an increase of T-helper type 1 (Th1) associated interferon-gamma expression while T-helper type 2 (Th2) associated interleukin-4 was the dominant cytokine prior to cyclophosphamide and after diabetes onset. We conclude that insulitis in young NOD mice is carried by Th2 cells while cyclophosphamide enhanced insulitis is determined by Th1 cells. Macrophages show two different functional states in insulitis; strong iNOS expression in macrophages is associated with destructive insulitis.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb Hdoi
10.1007/BF00418380subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1154-8issue
11eissn
0012-186Xissn
1432-0428journal_volume
37pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4073-6
更新日期:2016-11-01 00:00:00
abstract::We investigated the regulation of the mRNA expression of the insulin receptor, insulin receptor substrate-1 (IRS-1) and p85alpha-phosphatidylinositol-3-kinase (PI-3K), three major actors of insulin action, in skeletal muscle from 10 healthy lean volunteers, 13 obese patients with Type II (non-insulin-dependent) diabet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051163
更新日期:1999-03-01 00:00:00
abstract::The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00297455
更新日期:1989-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2864-6
更新日期:2013-05-01 00:00:00
abstract::The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...
journal_title:Diabetologia
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00125-018-4577-3
更新日期:2018-05-01 00:00:00
abstract::The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and co-released with insulin. Human islet amyloid polypeptide refolds to a beta-conformation and oligomerises to form insoluble fibrils; prol...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-003-1304-4
更新日期:2004-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0761-6
更新日期:2007-10-01 00:00:00
abstract::Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00745142
更新日期:1977-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Identifying the metabolite profile of individuals with normal fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early type 2 diabetes disease interception and detection. METHODS:We conducted a population-based prospective study among 1150 Framingham Hea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4599-x
更新日期:2018-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-017-4289-0
更新日期:2017-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00125-001-0763-8
更新日期:2002-04-01 00:00:00
abstract::Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274532
更新日期:1989-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract::The characteristics of familial Type I (insulin-dependent) diabetes mellitus-that is Type I diabetes in a first degree relative were investigated for children diagnosed before the age of 15 years using data from an international network of population-based registries (the EURODIAB ACE network) and from a case-control ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051044
更新日期:1998-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0762-5
更新日期:2007-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0912-9
更新日期:2008-03-01 00:00:00
abstract::To assess in vivo effects of antioxidants on vascular cell adhesion molecule (VCAM)-1 expression, circulating soluble VCAM-1 and intraerythrocytic reduced glutathione (GSH) and GSH disulphide (GSSG) concentrations were evaluated in non-insulin-dependent diabetic patients without complications (9 men, 6 women, 48 +/- 6...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s001250051082
更新日期:1998-11-01 00:00:00
abstract::Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050711
更新日期:1997-05-01 00:00:00
abstract::We describe a patient who had an anaphylactic reaction to highly purified pork insulin; he was not allergic however to beef insulin. The sensitivity to pork but not to beef insulin was confirmed by skin testing, radioallergosorbent test (RAST) and RAST inhibition. A scheme is suggested for the investigation of such pa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253575
更新日期:1982-05-01 00:00:00
abstract:AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05307-0
更新日期:2021-01-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-010-2030-3
更新日期:2011-05-01 00:00:00
abstract::The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00285332
更新日期:1989-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study wa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4424-y
更新日期:2017-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051218
更新日期:1999-06-01 00:00:00
abstract::The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/BF00400597
更新日期:1995-12-01 00:00:00
abstract::Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-019-05011-8
更新日期:2019-12-01 00:00:00
abstract::The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276966
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-04988-6
更新日期:2019-12-01 00:00:00