Abstract:
:We describe a patient who had an anaphylactic reaction to highly purified pork insulin; he was not allergic however to beef insulin. The sensitivity to pork but not to beef insulin was confirmed by skin testing, radioallergosorbent test (RAST) and RAST inhibition. A scheme is suggested for the investigation of such patients.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Carini C,Brostoff J,Kurtz ABdoi
10.1007/BF00253575subject
Has Abstractpub_date
1982-05-01 00:00:00pages
324-6issue
5eissn
0012-186Xissn
1432-0428journal_volume
22pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::Non-insulin-dependent diabetic (NIDDM) patients were studied during a modified euglycaemic state when fasting hyperglycaemia was normalized by a prior (-210 to -150 min)--and later withdrawn (-150-0 min)--intravenous insulin infusion. Glucose metabolism was assessed in NIDDM patients (n = 10) and matched control subje...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400638
更新日期:1995-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1434-4
更新日期:2009-09-01 00:00:00
abstract::The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin-resistant and diabetic humans exhibit defects in IRS-dependent signalling, implicating their dysregulation in the initiation and progre...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-012-2644-8
更新日期:2012-10-01 00:00:00
abstract::Type 1 (insulin-dependent) diabetes is less common in Asian Indians than in white Caucasoids. Forty-five Punjabi Asians with Type 1 diabetes and 96 racially matched control subjects were HLA-DR typed. DR3 was increased in diabetic patients vs control subjects (82% vs 38%, p less than 10(-5)) with relative risk 7.7 and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00277317
更新日期:1987-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0912-9
更新日期:2008-03-01 00:00:00
abstract::Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00869268
更新日期:1986-09-01 00:00:00
abstract::Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051089
更新日期:1998-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:In early type 1 diabetes mellitus, renal salt handling is dysregulated, so that the glomerular filtration rate becomes inversely proportional to salt intake. The salt paradox occurs in both humans and rats and, with low salt intake, results in diabetic hyperfiltration. We tested whether increased salt i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2569-2
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1036-6
更新日期:2008-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming adipose tissue dysfunction in LBW individuals. METHO...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4099-9
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2'-deoxyguanosine in DNA. To investigate the possible contribution of oxidative DNA damage to the path...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051258
更新日期:1999-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3074-y
更新日期:2014-01-01 00:00:00
abstract::AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2503-7
更新日期:2012-05-01 00:00:00
abstract::This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050680
更新日期:1997-03-01 00:00:00
abstract::The glucose phosphorylating enzyme glucokinase plays an important role in the regulation of glucose homeostasis. Studies in rodents indicate that pancreatic Beta cells and hepatocytes express different isoforms of this protein as a consequence of the presence of tissue-specific promoters and exon 1 sequences which are...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429094
更新日期:1992-08-01 00:00:00
abstract::498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219704
更新日期:1977-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. METHODS:The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05242-0
更新日期:2020-10-01 00:00:00
abstract::Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00428985
更新日期:1976-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes is induced by multiple low doses of streptozotocin (MLD-STZ) in male mice of susceptible strains. In this model beta-cell injury and T-cell-mediated inflammatory reactions are induced. Probably, reactive oxygen species (ROS) participate in the destruction of beta cells. The effects of ROS can b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050009
更新日期:2000-08-01 00:00:00
abstract::The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00278757
更新日期:1988-09-01 00:00:00
abstract::The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273803
更新日期:1984-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1424-5
更新日期:2004-06-01 00:00:00
abstract::Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223621
更新日期:1979-05-01 00:00:00
abstract::The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00408468
更新日期:1994-04-01 00:00:00
abstract::In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404643
更新日期:1990-06-01 00:00:00
abstract::Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00401763
更新日期:1995-11-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However...
journal_title:Diabetologia
pub_type: 社论
doi:10.1007/s00125-017-4306-3
更新日期:2017-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:It has been recently shown that glycated human haemoglobin induces endothelial dysfunction in rat vessels by generating superoxide anions that interfere with nitric oxide mediated responses. Our study analysed the effect of glycated human haemoglobin on the endothelium-dependent relaxations of human ves...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050011
更新日期:2000-01-01 00:00:00
abstract::We have investigated whether the previously demonstrated stimulatory actions of growth hormone on DNA synthesis and (pro)insulin biosynthesis and release of isolated adult rat islets of Langerhans are mediated by an autocrine release of somatomedin-C/insulin-like growth factor I (SM-C/IGF I). In medium containing 1% f...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265093
更新日期:1989-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-005-1737-z
更新日期:2005-05-01 00:00:00