Type 2 (non-insulin-dependent) diabetes mellitus, migration and westernisation: the Tokelau Island Migrant Study.

Abstract:

:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. The age standardised prevalence rates rose from 7.5 and 11.7 to 10.8 and 19.9 per 100 respectively in the male and female migrants compared with an increase from 3.0 and 8.7 to 7.0 and 14.3 per 100 in the non-migrant males and females respectively. The incidence of diabetes is shown to be consistently higher in the migrants compared to the non-migrants giving relative risks of 1.5 in males and 1.9 in females. The factors most likely contributing to this difference, are changes to a higher calorie, high protein diet, higher alcohol consumption, a greater weight gain and altered levels of physical activity in the migrants. A number of populations in the Pacific have been shown to have a low rate of diabetes in their traditional setting, but may have a genetic predisposition for diabetes which responds to factors in the urban industrialised environment and life-style. The social and economic changes taking place in Tokelau are also clearly increasing the risk of diabetes. To reverse these trends and prevent the development of complications of Type 2 diabetes, it will be important to institute preventive programmes and to follow up the population in both environments for long-term outcomes, including mortality.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

doi

10.1007/BF00285332

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

585-90

issue

8

eissn

0012-186X

issn

1432-0428

journal_volume

32

pub_type

杂志文章
  • Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihypertensive treatment.

    abstract::Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050140

    authors: Rossing P,Hommel E,Smidt UM,Parving HH

    更新日期:1994-05-01 00:00:00

  • Blood flow in the diabetic neuropathic foot.

    abstract::The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00253862

    authors: Edmonds ME,Roberts VC,Watkins PJ

    更新日期:1982-01-01 00:00:00

  • UK Prospective Diabetes Study (UKPDS). X. Urinary albumin excretion over 3 years in diet-treated type 2, (non-insulin-dependent) diabetic patients, and association with hypertension, hyperglycaemia and hypertriglyceridaemia.

    abstract::Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1993-10-01 00:00:00

  • Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose.

    abstract:AIMS/HYPOTHESIS:Identifying the metabolite profile of individuals with normal fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early type 2 diabetes disease interception and detection. METHODS:We conducted a population-based prospective study among 1150 Framingham Hea...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-018-4599-x

    authors: Merino J,Leong A,Liu CT,Porneala B,Walford GA,von Grotthuss M,Wang TJ,Flannick J,Dupuis J,Levy D,Gerszten RE,Florez JC,Meigs JB

    更新日期:2018-06-01 00:00:00

  • Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.

    abstract:AIMS/HYPOTHESIS:The purpose of this study was to assess the therapeutic implication of leptin in insulin-deficient diabetes. METHODS:Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. Plasma concentrations of glucose, insulin, and leptin were measured. The e...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-003-1193-6

    authors: Miyanaga F,Ogawa Y,Ebihara K,Hidaka S,Tanaka T,Hayashi S,Masuzaki H,Nakao K

    更新日期:2003-10-01 00:00:00

  • Disparity of autonomic control in type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:Acute insulinaemia activates the sympathetic drive in a nonuniform manner. The extent and nature of such activation in type 2 diabetic patients who do not have neuropathy have not yet been addressed despite evidence relating sympathetic activation to cardiovascular risk. We planned to determine the magn...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1601-6

    authors: Huggett RJ,Scott EM,Gilbey SG,Bannister J,Mackintosh AF,Mary DA

    更新日期:2005-01-01 00:00:00

  • Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.

    abstract::Recently, we described a leprechaun patient with a genetically transmitted severe insulin resistance due to the absence of functional insulin receptors as inferred from the loss of insulin binding to the patients' fibroblasts and the impaired autophosphorylation of the beta-chain of the receptor. This patient was homo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00274534

    authors: Lekanne Deprez RH,Potter van Loon BJ,van der Zon GC,Möller W,Lindhout D,Klinkhamer MP,Krans HM,Maassen JA

    更新日期:1989-10-01 00:00:00

  • Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

    abstract:AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-1018-8

    authors: Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

    更新日期:2008-07-01 00:00:00

  • B-type natriuretic peptide (BNP) affects the initial response to intravenous glucose: a randomised placebo-controlled cross-over study in healthy men.

    abstract:AIMS/HYPOTHESIS:B-type natriuretic peptide (BNP) is a hormone released from cardiomyocytes in response to cell stretching and elevated in heart failure. Recent observations indicate a distinct connection between chronic heart failure and diabetes mellitus. This study investigated the role of BNP on glucose metabolism. ...

    journal_title:Diabetologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00125-011-2392-1

    authors: Heinisch BB,Vila G,Resl M,Riedl M,Dieplinger B,Mueller T,Luger A,Pacini G,Clodi M

    更新日期:2012-05-01 00:00:00

  • The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. METHODS:We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the ye...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-0033-2

    authors: Knerr I,Wolf J,Reinehr T,Stachow R,Grabert M,Schober E,Rascher W,Holl RW,DPV Scientific Initiative of Germany and Austria.

    更新日期:2005-12-01 00:00:00

  • Proteinuria in the acutely diabetic rat and its response to insulin treatment.

    abstract::The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF03216225

    authors: Pennell JP,Millard MM,Ashby MH

    更新日期:1981-07-01 00:00:00

  • A prospective study of mortality among middle-aged diabetic patients (the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics) I: Causes and death rates.

    abstract::The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths an...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00404141

    authors: Morrish NJ,Stevens LK,Head J,Fuller JH,Jarrett RJ,Keen H

    更新日期:1990-09-01 00:00:00

  • Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice.

    abstract:AIMS/HYPOTHESIS:The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1414-7

    authors: Graiani G,Emanueli C,Desortes E,Van Linthout S,Pinna A,Figueroa CD,Manni L,Madeddu P

    更新日期:2004-06-01 00:00:00

  • Stimulation of adipose tissue lipolysis following insulin-induced hypoglycaemia: evidence of increased beta-adrenoceptor-mediated lipolytic response in IDDM.

    abstract::The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU.kg body weight-1.h-1 until the arterial plasma glucose fell below 2.8 mmol/l) was investigated directly in vivo in 11 insulin-dependent diabetic (IDDM) patients and 12 con...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050519

    authors: Bolinder J,Sjöberg S,Arner P

    更新日期:1996-07-01 00:00:00

  • Type 1 and type 2 diabetes after gestational diabetes: a 23 year cohort study.

    abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05215-3

    authors: Auvinen AM,Luiro K,Jokelainen J,Järvelä I,Knip M,Auvinen J,Tapanainen JS

    更新日期:2020-10-01 00:00:00

  • Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis.

    abstract:AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

    journal_title:Diabetologia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00125-007-0884-9

    authors: Golicki DT,Golicka D,Groele L,Pankowska E

    更新日期:2008-02-01 00:00:00

  • Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis.

    abstract::Lack of insulin receptors in mice is associated with near-normal intrauterine growth, unlike patients with leprechaunism, in whom growth deficiency is a prominent clinical feature. Genetic crosses of insulin receptor- and insulin-like growth-factor-1 (IGF-1) receptor-deficient mice indicate, however, that insulin rece...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050886

    authors: Cinti S,Eberbach S,Castellucci M,Accili D

    更新日期:1998-02-01 00:00:00

  • Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease.

    abstract:AIMS/HYPOTHESIS:Chemokines are chemotactic cytokines controlling the recruitment of leukocytes from the blood by regulating integrin adhesiveness. It has been shown that the migration of CD4+Th1 and CD4+Th2 cells is governed by specific chemokines. Increasing evidence suggests that the CD4+Th1 cheomoattractant chemokin...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-002-0879-5

    authors: Nicoletti F,Conget I,Di Mauro M,Di Marco R,Mazzarino MC,Bendtzen K,Messina A,Gomis R

    更新日期:2002-08-01 00:00:00

  • Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle.

    abstract:AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050013

    authors: Casis O,Gallego M,Iriarte M,Sánchez-Chapula JA

    更新日期:2000-01-01 00:00:00

  • 11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes.

    abstract::Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of glucocorticoid metabolism that are highlighted by clinical similarities between the sequelae of insulin resistance and Cushing's syndrome, as well as glucocorticoids' functional antagonism to insulin. 11beta-hydroxysteroid dehydrogenase ty...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-003-1284-4

    authors: Stulnig TM,Waldhäusl W

    更新日期:2004-01-01 00:00:00

  • A prospective study of endometriosis and risk of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05347-6

    authors: Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

    更新日期:2021-01-05 00:00:00

  • Symptoms, signs and complications in newly diagnosed type 2 diabetic patients, and their relationship to glycaemia, blood pressure and weight.

    abstract:AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1625-y

    authors: Drivsholm T,de Fine Olivarius N,Nielsen AB,Siersma V

    更新日期:2005-02-01 00:00:00

  • Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.

    abstract:AIMS/HYPOTHESIS:We examined in skeletal muscle (1) whether fatty acid transport protein (FATP) 1 channels long-chain fatty acid (LCFA) to specific metabolic fates in rats; and (2) whether FATP1-mediated increases in LCFA uptake exacerbate the development of diet-induced insulin resistance in mice. We also examined whet...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-011-2114-8

    authors: Holloway GP,Chou CJ,Lally J,Stellingwerff T,Maher AC,Gavrilova O,Haluzik M,Alkhateeb H,Reitman ML,Bonen A

    更新日期:2011-06-01 00:00:00

  • Can targeting ANGPTL proteins improve glucose tolerance?

    abstract::Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

    journal_title:Diabetologia

    pub_type: 评论,杂志文章

    doi:10.1007/s00125-018-4604-4

    authors: Davies BSJ

    更新日期:2018-06-01 00:00:00

  • The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study.

    abstract:AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-0017-2

    authors: Freedman BI,Hsu FC,Langefeld CD,Rich SS,Herrington DM,Carr JJ,Xu J,Bowden DW,Wagenknecht LE

    更新日期:2005-12-01 00:00:00

  • Insulin binding capacity in patients changed from conventional to highly purified insulins. An indicator of likely response.

    abstract::Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01223271

    authors: Mustaffa BE,Daggett PR,Nabarro JD

    更新日期:1977-08-01 00:00:00

  • Impaired autoregulation of glomerular filtration rate in type 1 (insulin-dependent) diabetic patients with nephropathy.

    abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00276965

    authors: Parving HH,Kastrup H,Smidt UM,Andersen AR,Feldt-Rasmussen B,Christiansen JS

    更新日期:1984-12-01 00:00:00

  • A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).

    abstract:AIMS/HYPOTHESIS:This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS). METHODS:A two-stage...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1373-0

    authors: Rich SS,Goodarzi MO,Palmer ND,Langefeld CD,Ziegler J,Haffner SM,Bryer-Ash M,Norris JM,Taylor KD,Haritunians T,Rotter JI,Chen YD,Wagenknecht LE,Bowden DW,Bergman RN

    更新日期:2009-07-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract::The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00273803

    authors: Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期:1984-08-01 00:00:00

  • Cellular basis of direct insulin action in the central nervous system.

    abstract::The in vivo radioautographic method has been applied to elucidate the mechanism of direct peptide hormone "feedback" action in the CNS. Using this method we have identified the circumventricular organs of the brain as general endocrine target tissues for a variety of blood-borne polypeptide hormones, including insulin...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00254491

    authors: van Houten M,Posner BI

    更新日期:1981-03-01 00:00:00