Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.

abstract：AIMS/HYPOTHESIS:Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesis...

journal_title：Diabetologia

authors： Abdelsaid M,Coucha M,Hafez S,Yasir A,Johnson MH,Ergul A

更新日期：2017-04-01 00:00:00

abstract：:[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i.v.) secondary to its binding to circulating albumin. The duration and activity profile of the acylated (A) and NPH (B) insulins were assessed fol...

journal_title：Diabetologia

authors： Radziuk J,Pye S,Bradley B,Braaten J,Vignati L,Roach P,Bowsher R,DiMarchi R,Chance R

更新日期：1998-01-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. METHODS:We studied 2,603 and 2,386 Europeans from the Botnia study and Malmö Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-u...

journal_title：Diabetologia

authors： Alyass A,Almgren P,Akerlund M,Dushoff J,Isomaa B,Nilsson P,Tuomi T,Lyssenko V,Groop L,Meyre D

更新日期：2015-01-01 00:00:00

abstract：:Epidemiologic data suggest that having a parent with Type 2 (non-insulin-dependent) diabetes mellitus increases the risk for Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 diabetes and Type 2 diabetes...

journal_title：Diabetologia

authors： Rich SS,Panter SS,Goetz FC,Hedlund B,Barbosa J

更新日期：1991-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...

journal_title：Diabetologia

authors： Kapitza C,Dahl K,Jacobsen JB,Axelsen MB,Flint A

更新日期：2017-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...

journal_title：Diabetologia

authors： Benhamou PY,Oberholzer J,Toso C,Kessler L,Penfornis A,Bayle F,Thivolet C,Martin X,Ris F,Badet L,Colin C,Morel P,GRAGIL consortium.

更新日期：2001-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-lowering therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors is associated with a low risk of hypoglycaemia. We hypothesise that DPP-4 inhibition prevents hypoglycaemia via increased glucagon counterregulation through the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). M...

journal_title：Diabetologia

authors： Malmgren S,Ahrén B

更新日期：2015-05-01 00:00:00

abstract：:Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed ...

journal_title：Diabetologia

authors： Boucher BJ,Ewen SW,Stowers JM

更新日期：1994-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study wa...

journal_title：Diabetologia

authors： Ometto G,Assheton P,Calivá F,Chudzik P,Al-Diri B,Hunter A,Bek T

更新日期：2017-12-01 00:00:00

abstract：:For many, the extent to which blood glucose control can be lowered is limited by risk of hypoglycaemia. Hypoglycaemia is feared and carries fiscal, social and medical costs, with risk of death being associated with severe hypoglycaemia in patients with type 2 diabetes at high cardiovascular risk. In this issue of Diab...

journal_title：Diabetologia

authors： Neupane S,Evans ML

更新日期：2015-06-01 00:00:00

abstract：:The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-d...

journal_title：Diabetologia

authors： Bollen M,Keppens S,Stalmans W

更新日期：1988-09-01 00:00:00

abstract：:Developmental changes in the plasma insulin response to milk ingestion have been determined in neonatal lambs fed by bottle and in naturally suckled infant rabbits. In lambs at 4 days of age and older plasma insulin increased within 5 min of suckling and declined again before increasing to a second peak 60 to 120 min ...

journal_title：Diabetologia

authors： Porter RJ,Bassett JM

更新日期：1979-03-01 00:00:00

abstract：:The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...

journal_title：Diabetologia

authors： Dolais-Kitabgi J,Alengrin F,Freychet P

更新日期：1983-06-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...

journal_title：Diabetologia

authors： Chamnan P,Simmons RK,Sharp SJ,Griffin SJ,Wareham NJ

更新日期：2009-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:In previous studies we have shown a significant involvement of the growth hormone (GH)-IGF axis in animal models of type 1 diabetes mellitus, but the role of this endocrine system in type 2 diabetes mellitus is less well characterised. We therefore examined the endocrine and renal GH-IGF axis changes in...

journal_title：Diabetologia

authors： Segev Y,Eshet R,Yakir O,Haim N,Phillip M,Landau D

更新日期：2007-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Epithelium-mesenchyme interactions play a major role in pancreas development. Recently, we demonstrated that embryonic pancreatic mesenchyme enhanced progenitor cell proliferation but inhibited endocrine cell differentiation. Here, we investigated the role played by sulphated proteoglycans, which are kn...

journal_title：Diabetologia

authors： Zertal-Zidani S,Bounacer A,Scharfmann R

更新日期：2007-03-01 00:00:00

abstract：:The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...

journal_title：Diabetologia

authors： Osterby R,Nyberg G,Hedman L,Karlberg I,Persson H,Svalander C

更新日期：1991-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

journal_title：Diabetologia

authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

更新日期：2007-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimer...

journal_title：Diabetologia

authors： Cervin C,Orho-Melander M,Ridderstråle M,Lehto M,Barg S,Groop L,Cilio CM

更新日期：2002-12-01 00:00:00

abstract：:It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...

journal_title：Diabetologia

authors： Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

更新日期：1996-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Acute insulinaemia activates the sympathetic drive in a nonuniform manner. The extent and nature of such activation in type 2 diabetic patients who do not have neuropathy have not yet been addressed despite evidence relating sympathetic activation to cardiovascular risk. We planned to determine the magn...

journal_title：Diabetologia

authors： Huggett RJ,Scott EM,Gilbey SG,Bannister J,Mackintosh AF,Mary DA

更新日期：2005-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

journal_title：Diabetologia

authors： Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

更新日期：2020-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

journal_title：Diabetologia

authors： Jiang Y,Jakobsen J

更新日期：2004-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...

journal_title：Diabetologia

authors： Wägner AM,Cloos P,Bergholdt R,Boissy P,Andersen TL,Henriksen DB,Christiansen C,Christgau S,Pociot F,Nerup J

更新日期：2007-03-01 00:00:00

abstract：:Fasting (24 h) normal dogs and depancreatized dogs were injected intravenously with highly purified porcine insulin (Actrapid) in the doses of 0.2 U/kg and 0.5 U/kg, respectively. Blood glucose decreased from 152 +/- 41 (SEM) mg/100 ml to 39 +/- 7 mg/100 ml in the depancreatized dog and from 95 +/- 3 mg/100 ml to 42 +...

journal_title：Diabetologia

authors： Matsuyama T,Tanaka R,Shima K,Nonaka K,Tarui S

更新日期：1978-12-01 00:00:00

abstract：:Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without ne...

journal_title：Diabetologia

authors： Saudek F,Pelikánová T,Bartos V,Reneltová I,Kazdová L,Kovár J,Karasová L

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

journal_title：Diabetologia

authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

更新日期：2006-01-01 00:00:00

abstract：:Alloxan-induced diabetes in rats significantly impaired the capacity of the erythrocytes to metabolise glucose in vitro to either lactic acid or CO2. Both these metabolic activities were initially insensitive to insulin in normal as well as in diabetic animals; but became responsive when these cells were subjected to ...

journal_title：Diabetologia

authors： Agarwal VR,Rastogi AK,Sagar P

更新日期：1988-01-01 00:00:00