Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.

abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...

journal_title：Diabetologia

authors： Fontela T,Garcia Hermida O,Gómez-Acebo J

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We analysed the cost-effectiveness of intensified prevention in diabetic patients with different risks for foot ulcers and lower extremity amputations. Specifically, we examined whether the additional prevention costs associated with present recommendations would be offset by reduced costs of future foo...

journal_title：Diabetologia

authors： Ragnarson Tennvall G,Apelqvist J

更新日期：2001-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...

journal_title：Diabetologia

authors： Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns W

更新日期：1980-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The effects of successful pancreas transplant alone (PTA) on chronic complications of diabetes, in particular diabetic retinopathy, remain disputed. We prospectively studied the course of diabetic retinopathy in PTA recipients and in non-transplanted (non-PTA) type 1 diabetic patients. METHODS:The PTA ...

journal_title：Diabetologia

authors： Giannarelli R,Coppelli A,Sartini MS,Del Chiaro M,Vistoli F,Rizzo G,Barsotti M,Del Prato S,Mosca F,Boggi U,Marchetti P

更新日期：2006-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：:An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...

journal_title：Diabetologia

authors： Ehrlich RM,Walsh LJ,Falk JA,Middleton PJ,Simpson NE

更新日期：1982-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

journal_title：Diabetologia

authors： Golicki DT,Golicka D,Groele L,Pankowska E

更新日期：2008-02-01 00:00:00

abstract：:Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...

journal_title：Diabetologia

authors： Takeda J,Seino Y,Yoshimasa Y,Fukumoto H,Koh G,Kuzuya H,Imura H,Seino S

更新日期：1986-09-01 00:00:00

abstract：:In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared wit...

journal_title：Diabetologia

authors： Flax H,Matthews DR,Levy JC,Coppack SW,Turner RC

更新日期：1991-08-01 00:00:00

abstract：:Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...

journal_title：Diabetologia

authors： Elliott HR,Sharp GC,Relton CL,Lawlor DA

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...

journal_title：Diabetologia

authors： Edge JA,Jakes RW,Roy Y,Hawkins M,Winter D,Ford-Adams ME,Murphy NP,Bergomi A,Widmer B,Dunger DB

更新日期：2006-09-01 00:00:00

abstract：:Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...

journal_title：Diabetologia

authors： Seyer-Hansen K

更新日期：1977-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...

journal_title：Diabetologia

authors： Leibowitz G,Khaldi MZ,Shauer A,Parnes M,Oprescu AI,Cerasi E,Jonas JC,Kaiser N

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Chemokines are chemotactic cytokines controlling the recruitment of leukocytes from the blood by regulating integrin adhesiveness. It has been shown that the migration of CD4+Th1 and CD4+Th2 cells is governed by specific chemokines. Increasing evidence suggests that the CD4+Th1 cheomoattractant chemokin...

journal_title：Diabetologia

authors： Nicoletti F,Conget I,Di Mauro M,Di Marco R,Mazzarino MC,Bendtzen K,Messina A,Gomis R

更新日期：2002-08-01 00:00:00

abstract：:Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

journal_title：Diabetologia

authors： Davies BSJ

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...

journal_title：Diabetologia

authors： Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HA

更新日期：2016-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

journal_title：Diabetologia

authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:125I-insulin binding and receptor-mediated insulin degradation were studied in isolated human fat cells from subcutaneous tissue. A high albumin concentration during cell isolation and incubation protected the fragile human adipocyte from lysis. Binding of tracer was pH dependent with an optimum between 7.4 ...

journal_title：Diabetologia

authors： Pedersen O,Hjøllund E,Beck-Nielsen H,Lindskov HO,Sonne O,Gliemann J

更新日期：1981-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...

journal_title：Diabetologia

authors： Van Hove I,De Groef L,Boeckx B,Modave E,Hu TT,Beets K,Etienne I,Van Bergen T,Lambrechts D,Moons L,Feyen JHM,Porcu M

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

journal_title：Diabetologia

authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

更新日期：2013-02-01 00:00:00

abstract：:Patients with insulin-dependent diabetes mellitus (IDDM) have a pathological increase in cholesteryl ester transfer (CET) that enriches the apolipoprotein B-containing lipoproteins with cholesteryl ester and increases their atherogenicity. Since we have shown earlier that omega-3 (n-3) fatty acids present in marine li...

journal_title：Diabetologia

authors： Bagdade JD,Ritter M,Subbaiah PV

更新日期：1996-04-01 00:00:00

abstract：:To test the hypothesis that interaction between genetic, immunological, clinical and metabolic risk factors influences the outcome of Type II (non-insulin-dependent) diabetes mellitus, we examined which of the above factors present at baseline were associated with mortality in 134 Type II diabetic patients followed fo...

journal_title：Diabetologia

authors： Forsblom CM,Sane T,Groop PH,Tötterman KJ,Kallio M,Saloranta C,Laasonen L,Summanen P,Lepäntalo M,Laatikainen L,Matikainen E,Teppo AM,Koskimies S,Groop L

更新日期：1998-11-01 00:00:00

abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

journal_title：Diabetologia

authors： Paisey RB,Harkness J,Hartog M,Chadwick T

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2.6%. Since then the prevalence of diabetes has doubled and the organisation of diabetes care has undergone major changes. Up-to-date data that quantify the occurren...

journal_title：Diabetologia

authors： Stoekenbroek RM,Lokin JLC,Nielen MM,Stroes ESG,Koelemay MJW

更新日期：2017-07-01 00:00:00

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：:Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

journal_title：Diabetologia

authors： Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

更新日期：1990-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

journal_title：Diabetologia

authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

更新日期：2000-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

journal_title：Diabetologia

authors： Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...

journal_title：Diabetologia

authors： Bidel S,Hu G,Qiao Q,Jousilahti P,Antikainen R,Tuomilehto J

更新日期：2006-11-01 00:00:00