当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Kidney transplantation in type 1 (insulin-dependent) diabetic patients. Early glomerulopathy.

Kidney transplantation in type 1 (insulin-dependent) diabetic patients. Early glomerulopathy.

Abstract：

:The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dependent) diabetic patients and 8 non-diabetic control subjects with a glomerular filtration rate more than 30 ml.min-1 at follow-up. Immunosuppressive therapy included cyclosporine in all but one case. Stereological methods were used to assess basement membrane thickness, volume fraction of mesangium per glomerulus, and volume fraction of matrix per mesangium. The volume fraction of interstitial tissue per cortex was estimated by light microscopy. After 2 years the basement membrane thickness had increased by 55 nm (SD 58 nm) in the diabetic group. This change was significantly different from that of 2 nm (SD 37 nm) in control subjects (p = 0.02). Mesangial volume fraction increased significantly by 0.04 (SD 0.03) in diabetic patients, and this change was significantly different from that of -0.01 (SD 0.04) in non-diabetic patients (p = 0.009). No change was detectable in the matrix expressed as fraction of mesangial volume. An increase in interstitial volume fraction from baseline to 2 years was observed, but was significant only in the diabetic group (p = 0.04). The changes in structural parameters did not correlate with mean values during follow-up of glycated haemoglobin or estimated protein intake, nor was any pattern discernible in the relationship to graft tissue types.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Diabetologia

journal_title

Diabetologia

authors

Osterby R,Nyberg G,Hedman L,Karlberg I,Persson H,Svalander C

doi

10.1007/BF00400997

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

668-74

issue

9

eissn

0012-186X

issn

1432-0428

journal_volume

34

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Mitogen-activated protein kinases as glucose transducers for diabetic complications.

    abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s001250051439

    authors： Tomlinson DR

    更新日期：1999-11-01 00:00:00

  • Effects of an acute decrease in non-esterified fatty acid levels on muscle glucose utilization and forearm indirect calorimetry in lean NIDDM patients.

    abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00400420

    authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

    更新日期：1996-01-01 00:00:00

  • Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice.

    abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2578-1

    authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

    更新日期：2012-08-01 00:00:00

  • Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy.

    abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399934

    authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

    更新日期：1992-09-01 00:00:00

  • A prospective study of mortality among middle-aged diabetic patients (the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics) I: Causes and death rates.

    abstract：:The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths an...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00404141

    authors： Morrish NJ,Stevens LK,Head J,Fuller JH,Jarrett RJ,Keen H

    更新日期：1990-09-01 00:00:00

  • The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051628

    authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

    更新日期：2001-03-01 00:00:00

  • Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids.

    abstract：:The aim of the present study was to measure whole body glucose uptake (M) and oxidation rate by euglycaemic hyperinsulinaemic clamp and indirect calorimetry in 7 morbidly obese subjects (BMI > 40 kg/m2) at three time points: before bilio-pancreatic diversion (BPD) surgery (Ob); 3 months after surgery POI; and after re...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050721

    authors： Mingrone G,DeGaetano A,Greco AV,Capristo E,Benedetti G,Castagneto M,Gasbarrini G

    更新日期：1997-05-01 00:00:00

  • Genetic risk scores ascertained in early adulthood and the prediction of type 2 diabetes later in life.

    abstract：:It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants tha...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-012-2683-1

    authors： Franks PW

    更新日期：2012-10-01 00:00:00

  • Immunoisolation of pancreatic B cells by microencapsulation. An in vitro study.

    abstract：:The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265027

    authors： Darquy S,Reach G

    更新日期：1985-10-01 00:00:00

  • Calcium and phosphate concentrations and future development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

    abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3241-9

    authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

    更新日期：2014-07-01 00:00:00

  • The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus.

    abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s001250100580

    authors： Pratley RE,Weyer C

    更新日期：2001-08-01 00:00:00

  • Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1678-6

    authors： Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

    更新日期：2005-04-01 00:00:00

  • The clinical and hormonal (C-peptide and glucagon) profile and liability to ketoacidosis during nutritional rehabilitation in Ethiopian patients with malnutrition-related diabetes mellitus.

    abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00404800

    authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

    更新日期：1990-04-01 00:00:00

  • Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1575-5

    authors： Dong YF,Liu L,Kataoka K,Nakamura T,Fukuda M,Tokutomi Y,Nako H,Ogawa H,Kim-Mitsuyama S

    更新日期：2010-01-01 00:00:00

  • Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells.

    abstract：:Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051089

    authors： Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

    更新日期：1998-12-01 00:00:00

  • Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.

    abstract：AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0942-y

    authors： Ellard S,Bellanné-Chantelot C,Hattersley AT,European Molecular Genetics Quality Network (EMQN) MODY group.

    更新日期：2008-04-01 00:00:00

  • Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study.

    abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2312-4

    authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

    更新日期：2012-01-01 00:00:00

  • Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin.

    abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2661-7

    authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

    更新日期：2012-11-01 00:00:00

  • A vascular mechanism for high-sodium-induced insulin resistance in rats.

    abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3373-y

    authors： Premilovac D,Richards SM,Rattigan S,Keske MA

    更新日期：2014-12-01 00:00:00

  • Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes.

    abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-3948-x

    authors： Huo L,Shaw JE,Wong E,Harding JL,Peeters A,Magliano DJ

    更新日期：2016-07-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00273803

    authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期：1984-08-01 00:00:00

  • Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects.

    abstract：:Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00401763

    authors： Chaiken RL,Eckert-Norton M,Pasmantier R,Boden G,Ryan I,Gelfand RA,Lebovitz HE

    更新日期：1995-11-01 00:00:00

  • Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

    abstract：AIMS/HYPOTHESIS:Simultaneous kidney-pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1237-z

    authors： Velthuis JH,Unger WW,van der Slik AR,Duinkerken G,Engelse M,Schaapherder AF,Ringers J,van Kooten C,de Koning EJ,Roep BO

    更新日期：2009-03-01 00:00:00

  • A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population.

    abstract：AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1241-3

    authors： Hu C,Zhang R,Wang C,Ma X,Wang C,Fang Q,Bao Y,Xiang K,Jia W

    更新日期：2009-03-01 00:00:00

  • The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1003-2

    authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

    更新日期：2008-07-01 00:00:00

  • Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in amyloidogenesis.

    abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050751

    authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

    更新日期：1997-07-01 00:00:00

  • Direct effect of GLP-1 infusion on endogenous glucose production in humans.

    abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-012-2738-3

    authors： Seghieri M,Rebelos E,Gastaldelli A,Astiarraga BD,Casolaro A,Barsotti E,Pocai A,Nauck M,Muscelli E,Ferrannini E

    更新日期：2013-01-01 00:00:00

  • Diabetes: the genetic connections.

    abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/BF01236266

    authors： Pyke DA

    更新日期：1979-12-01 00:00:00

  • Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease.

    abstract：:Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051004

    authors： Seissler J,de Sonnaville JJ,Morgenthaler NG,Steinbrenner H,Glawe D,Khoo-Morgenthaler UY,Lan MS,Notkins AL,Heine RJ,Scherbaum WA

    更新日期：1998-08-01 00:00:00

  • Macrosomia despite good glycaemic control in Type I diabetic pregnancy; results of a nationwide study in The Netherlands.

    abstract：AIMS/HYPOTHESIS:To investigate the incidence of foetal macrosomia (i.e. birth weight >90th percentile) in a non-selected nationwide cohort of women with Type I (insulin-dependent) diabetes mellitus in The Netherlands and to identify risk indicators predictive for macrosomia. METHODS:We conducted a prospective nationwi...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-002-0958-7

    authors： Evers IM,de Valk HW,Mol BW,ter Braak EW,Visser GH

    更新日期：2002-11-01 00:00:00