Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.

abstract：AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...

journal_title：Diabetologia

authors： Kamimoto Y,Sugiyama T,Kihira T,Zhang L,Murabayashi N,Umekawa T,Nagao K,Ma N,Toyoda N,Yodoi J,Sagawa N

更新日期：2010-09-01 00:00:00

abstract：:QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...

journal_title：Diabetologia

authors： Ewing DJ,Boland O,Neilson JM,Cho CG,Clarke BF

更新日期：1991-03-01 00:00:00

abstract：:In perifused pancreatic islets, the fluorescence of oxidized flavoproteins (FAD) was recorded continuously. Elevation of glucose concentration in the medium form 0 or 5 mM to 20 mM led to decrease in FAD-fluorescence beginning 10 sec after change of medium. L-leucine (10 mM), (+/-)-B-BCH (20 mM) and alpha-ketoisocapro...

journal_title：Diabetologia

authors： Panten U,Ishida H

更新日期：1975-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional s...

journal_title：Diabetologia

authors： Perez-Alcantara M,Honoré C,Wesolowska-Andersen A,Gloyn AL,McCarthy MI,Hansson M,Beer NL,van de Bunt M

更新日期：2018-07-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...

journal_title：Diabetologia

authors： Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

更新日期：2001-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sig...

journal_title：Diabetologia

authors： Burdon KP,Fogarty RD,Shen W,Abhary S,Kaidonis G,Appukuttan B,Hewitt AW,Sharma S,Daniell M,Essex RW,Chang JH,Klebe S,Lake SR,Pal B,Jenkins A,Govindarjan G,Sundaresan P,Lamoureux EL,Ramasamy K,Pefkianaki M,Hykin PG

更新日期：2015-10-01 00:00:00

abstract：:Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this approach is, however, scant and few pharmacological agents have proved effective enough to become part of routine clinical care. Recent short-term P...

journal_title：Diabetologia

authors： McCrimmon RJ,Henry RR

更新日期：2018-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain natriuretic peptide (BNP) is a potent vasorelaxing and natriuretic peptide that is secreted from the heart and has cardioprotective properties. We have previously generated hypotensive transgenic mice (BNP-Tg mice) that overproduce BNP in the liver, which is released into the circulation. Using th...

journal_title：Diabetologia

authors： Makino H,Mukoyama M,Mori K,Suganami T,Kasahara M,Yahata K,Nagae T,Yokoi H,Sawai K,Ogawa Y,Suga S,Yoshimasa Y,Sugawara A,Tanaka I,Nakao K

更新日期：2006-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...

journal_title：Diabetologia

authors： Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

更新日期：2020-03-01 00:00:00

abstract：:Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration...

journal_title：Diabetologia

authors： Drummond K,Levy-Marchal C,Laborde K,Kindermans C,Wright C,Dechaux M,Czernichow P

更新日期：1989-04-01 00:00:00

abstract：:IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...

journal_title：Diabetologia

authors： Schaefer L,Schaefer RM,Ling H,Teschner M,Heidland A

更新日期：1994-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

journal_title：Diabetologia

authors： Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

更新日期：2012-06-01 00:00:00

abstract：:The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

journal_title：Diabetologia

authors： Rodrigues M,Currier C,Yoon J

更新日期：1983-04-01 00:00:00

abstract：:Insulin and somatostatin reportedly affect pancreatic acinar cell function via specific receptor binding. Theoretically peri-insular levels depend on the islet-acinar portal system, but the actual hormone levels have never been demonstrated. Rat pancreata were perfused anterogradely or retrogradely with 125I-insulin, ...

journal_title：Diabetologia

authors： Nakagawa A,Stagner JI,Samols E

更新日期：1995-03-01 00:00:00

abstract：:Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of glucocorticoid metabolism that are highlighted by clinical similarities between the sequelae of insulin resistance and Cushing's syndrome, as well as glucocorticoids' functional antagonism to insulin. 11beta-hydroxysteroid dehydrogenase ty...

journal_title：Diabetologia

authors： Stulnig TM,Waldhäusl W

更新日期：2004-01-01 00:00:00

abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

journal_title：Diabetologia

authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

更新日期：1986-10-01 00:00:00

abstract：:We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue wit...

journal_title：Diabetologia

authors： Goode NP,Shires M,Crellin DM,Aparicio SR,Davison AM

更新日期：1995-12-01 00:00:00

abstract：:Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...

journal_title：Diabetologia

authors： Koffler M,Imamura T,Santeusanio F,Helderman JH

更新日期：1988-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...

journal_title：Diabetologia

authors： Kriz J,Padjen AL

更新日期：2003-02-01 00:00:00

abstract：:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...

journal_title：Diabetologia

authors： Hart WM,Espinosa C,Rovira J

更新日期：1997-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both ...

journal_title：Diabetologia

authors： Delaigle AM,Senou M,Guiot Y,Many MC,Brichard SM

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The mechanisms by which transcription factor 7-like 2 (TCF7L2) regulates the pathways that are important in the pathogenesis of type 2 diabetes are unknown. We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF...

journal_title：Diabetologia

authors： Norton L,Fourcaudot M,Abdul-Ghani MA,Winnier D,Mehta FF,Jenkinson CP,Defronzo RA

更新日期：2011-12-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

journal_title：Diabetologia

authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

更新日期：1998-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

journal_title：Diabetologia

authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

更新日期：2001-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of this work were to assess glycaemic control in metformin users receiving their first add-on glucose-lowering therapy and to examine the real-life effectiveness of different add-on drugs. METHODS:We carried out a population-based cohort study using healthcare databases in northern Denmark dur...

journal_title：Diabetologia

authors： Thomsen RW,Baggesen LM,Søgaard M,Pedersen L,Nørrelund H,Buhl ES,Haase CL,Johnsen SP

更新日期：2015-10-01 00:00:00

abstract：:Diabetes mellitus in Macaca mulatta rhesus monkeys is preceded by phases of obesity and hyperinsulinaemia and is similar to Type 2 (non-insulin-dependent) diabetes mellitus in man. To relate the progression of the disease to quantitative changes in islet morphology, post-mortem pancreatic tissue from 26 monkeys was ex...

journal_title：Diabetologia

authors： de Koning EJ,Bodkin NL,Hansen BC,Clark A

更新日期：1993-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Delivery of the gene for human vascular endothelial growth factor (VEGF, also known as VEGFA) to both the transplanted islets and the surrounding tissue may promote islet revascularisation and survival. We previously showed the effective delivery of VEGF gene to rat myocardium by an ultrasound-mediated ...

journal_title：Diabetologia

authors： Shimoda M,Chen S,Noguchi H,Matsumoto S,Grayburn PA

更新日期：2010-08-01 00:00:00