Blood-based signatures in type 1 diabetes.

abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

journal_title：Diabetologia

authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

更新日期：2017-06-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

journal_title：Diabetologia

authors： Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

更新日期：1991-11-01 00:00:00

abstract：:Among monosaccharides, fructose has a small hyperglycaemic effect. In order to better explain the mechanisms which cause this metabolic property, we used tracers labelled with stable isotopes (deuterated glucose and naturally 13C labelled fructose) to quantify the overall glucose appearance, the rate of appearance in ...

journal_title：Diabetologia

authors： Delarue J,Normand S,Pachiaudi C,Beylot M,Lamisse F,Riou JP

更新日期：1993-04-01 00:00:00

abstract：:[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i.v.) secondary to its binding to circulating albumin. The duration and activity profile of the acylated (A) and NPH (B) insulins were assessed fol...

journal_title：Diabetologia

authors： Radziuk J,Pye S,Bradley B,Braaten J,Vignati L,Roach P,Bowsher R,DiMarchi R,Chance R

更新日期：1998-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

journal_title：Diabetologia

authors： Premilovac D,Richards SM,Rattigan S,Keske MA

更新日期：2014-12-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...

journal_title：Diabetologia

authors： Florez JC,Jablonski KA,McAteer J,Sandhu MS,Wareham NJ,Barroso I,Franks PW,Altshuler D,Knowler WC,Diabetes Prevention Program Research Group.

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus is a heterogeneous disorder characterised by impaired insulin secretion and action. Our aim was to study whether autoimmunity, variations in genes affecting insulin secretion and action, or both, contribute to the development of gestational diabetes and whether the pathogen...

journal_title：Diabetologia

authors： Shaat N,Ekelund M,Lernmark A,Ivarsson S,Nilsson A,Perfekt R,Berntorp K,Groop L

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

journal_title：Diabetologia

authors： Look AHEAD Research Group.

更新日期：2015-08-01 00:00:00

abstract：:The metabolic and hormonal effects of stable hyperglycaemia (10-12 mmol/l) have been examined in five insulin-dependent diabetics and compared with the results of 8 h (1200 to 2000 h) normoglycaemic (5-6 mmol/l) clamping. Glucose levels were maintained using a glucose controlled insulin infusion system. Mean blood lac...

journal_title：Diabetologia

authors： Nosadini R,Noy GA,Alberti KG,Hodson A,Orskoy H

更新日期：1981-02-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：:There is evidence that the immune system may play a role in the pathogenesis of autonomic neuropathy in Type 1 (insulin-dependent) diabetes mellitus. In the present study, we investigated the presence of autoantibodies to sympathetic and parasympathetic nervous structures and their correlation with other conventional ...

journal_title：Diabetologia

authors： Zanone MM,Peakman M,Purewal T,Watkins PJ,Vergani D

更新日期：1993-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...

journal_title：Diabetologia

authors： Auvinen AM,Luiro K,Jokelainen J,Järvelä I,Knip M,Auvinen J,Tapanainen JS

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...

journal_title：Diabetologia

authors： Kallas-Koeman MM,Kong JM,Klinke JA,Butalia S,Lodha AK,Lim KI,Duan QM,Donovan LE

更新日期：2014-04-01 00:00:00

abstract：:Studies were made on the effect of the enteroinsular axis on amino acid-induced insulin and glucagon secretion during hyperglycaemia in man. The responses of plasma immunoreactive insulin, C-peptide, and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hypergly...

journal_title：Diabetologia

authors： Shimizu I,Hirota M,Ohboshi C,Mizuno A,Shima K

更新日期：1987-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Dysfunction of lipid metabolism in white adipose tissue can substantially interfere with health and quality of life, for example in obesity and associated metabolic diseases. Therefore, it is important to characterise pathways that regulate lipid handling in adipocytes and determine how they affect meta...

journal_title：Diabetologia

authors： Kaltenecker D,Mueller KM,Benedikt P,Feiler U,Themanns M,Schlederer M,Kenner L,Schweiger M,Haemmerle G,Moriggl R

更新日期：2017-02-01 00:00:00

abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...

journal_title：Diabetologia

authors： George E,Harris N,Bedford C,Macdonald IA,Hardisty CA,Heller SR

更新日期：1995-10-01 00:00:00

abstract：:The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

journal_title：Diabetologia

authors： Darquy S,Reach G

更新日期：1985-10-01 00:00:00

abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

journal_title：Diabetologia

authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

更新日期：2012-11-01 00:00:00

abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...

journal_title：Diabetologia

authors： Greaves M,Pickering C,Knight G,Boulton AJ,Ball J,Ward JD,Preston FE

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...

journal_title：Diabetologia

authors： Davis WA,Zilkens RR,Starkstein SE,Davis TM,Bruce DG

更新日期：2017-01-01 00:00:00

abstract：:In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...

journal_title：Diabetologia

authors： Widness JA,Teramo KA,Clemons GK,Voutilainen P,Stenman UH,McKinlay SM,Schwartz R

更新日期：1990-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...

journal_title：Diabetologia

authors： Lee CH,Cheung CYY,Woo YC,Lui DTW,Yuen MMA,Fong CHY,Chow WS,Xu A,Lam KSL

更新日期：2019-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate clinical and sociodemographic predictors of birthweight in singletons born to women with type 1 or type 2 diabetes. METHODS:Normally formed singleton live births and intrapartum stillbirths, born to women with pre-conception diabetes during 1996-2008, were identified from the population-...

journal_title：Diabetologia

authors： Glinianaia SV,Tennant PW,Bilous RW,Rankin J,Bell R

更新日期：2012-12-01 00:00:00

abstract：:The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...

journal_title：Diabetologia

authors： Fagius J,Brattberg A,Jameson S,Berne C

更新日期：1985-06-01 00:00:00

abstract：:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...

journal_title：Diabetologia

authors： Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns W

更新日期：1980-01-01 00:00:00

abstract：:The capacity of reovirus type 3 to infect insulin-producing B cells was studied in human pancreatic cell cultures. Antibody to reovirus was labelled with fluorescein isothiocyanate and antibody to insulin was labelled with tetramethyl rhodamine isothiocyanate. By using a double-labelled immunofluorescent antibody tech...

journal_title：Diabetologia

authors： Yoon JW,Selvaggio S,Onodera T,Wheeler J,Jenson AB

更新日期：1981-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...

journal_title：Diabetologia

authors： Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJ

更新日期：2013-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...

journal_title：Diabetologia

authors： Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

更新日期：2021-01-01 00:00:00