Abstract:
:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order and rate of change) were used as algorithm parameters in glucose-controlled insulin infusions. These were carried out in each dog based on individual estimations before the induction of diabetes but in the diabetic patients based on values derived from a group of normal subjects. Using this formula, nearly normal patterns of glucose and of insulin were observed in diabetic men and dogs under basal conditions and after IV glucose loading but not after meals. This algorithm enables selection of the parameters prospectively. The effect of a parameter combination depends on insulin sensitivity and it should be appropriately adapted. In the diabetic patients there was no predictable influence of the brittle or stable characteristics of the disease nor of insulin antibodies on the glucose curves obtained with glucose controlled insulin infusions.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns Wdoi
10.1007/BF00290484subject
Has Abstractpub_date
1980-01-01 00:00:00pages
97-107issue
2eissn
0012-186Xissn
1432-0428journal_volume
18pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4643-x
更新日期:2018-08-01 00:00:00
abstract::The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00277416
更新日期:1988-05-01 00:00:00
abstract::We examined the origin of hypermethioninaemia in streptozotocin-diabetic rats. In rats administered streptozotocin over a range from 55 to 75 mg/kg, the dose of drug injected correlated directly with the plasma methionine concentration and inversely with the plasma insulin level. Although insulin administration preven...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273913
更新日期:1984-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3241-9
更新日期:2014-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. METHODS:The research was carried out within the Diabetes Prediction and Prevention...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1734-8
更新日期:2010-08-01 00:00:00
abstract::The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00278757
更新日期:1988-09-01 00:00:00
abstract::Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281298
更新日期:1982-04-01 00:00:00
abstract::Lack of insulin receptors in mice is associated with near-normal intrauterine growth, unlike patients with leprechaunism, in whom growth deficiency is a prominent clinical feature. Genetic crosses of insulin receptor- and insulin-like growth-factor-1 (IGF-1) receptor-deficient mice indicate, however, that insulin rece...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050886
更新日期:1998-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051668
更新日期:2001-05-01 00:00:00
abstract::The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274531
更新日期:1989-10-01 00:00:00
abstract::Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401060
更新日期:1993-11-01 00:00:00
abstract::Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281820
更新日期:1980-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0556-1
更新日期:2007-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1810-7
更新日期:2005-08-01 00:00:00
abstract::An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin-allergy. No differences were observed between normal perso...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429705
更新日期:1978-01-14 00:00:00
abstract::We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279934
更新日期:1983-09-01 00:00:00
abstract::Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without ne...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00587624
更新日期:1991-08-01 00:00:00
abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050751
更新日期:1997-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production. METHODS:Erythrocy...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0853-3
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS:Participants without dementia aged 55-90 years from the Cognition...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4778-9
更新日期:2019-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051546
更新日期:2000-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fulminant type 1 diabetes, which is characterised by a markedly acute onset of diabetes and an absence of islet-related autoantibodies, accounts for 20% of type 1 diabetes in Japan. We aimed to clarify the contribution of the HLA subtype to fulminant type 1 diabetes in Japanese. METHODS:We determined t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1626-x
更新日期:2005-02-01 00:00:00
abstract::In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02341509
更新日期:1988-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1721-0
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0331-3
更新日期:2006-09-01 00:00:00
abstract::Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-013-3159-7
更新日期:2014-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1710-x
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s001250051637
更新日期:2001-04-01 00:00:00
abstract::The systolic time intervals at rest of 16 Type 1 (insulin-dependent) and 30 Type 2 (non-insulin-dependent) otherwise healthy adult diabetic patients selected from primary health care clinics were compared with those of age- and sex-matched normal subjects by paired analysis. There was no significant difference in prev...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282708
更新日期:1983-04-01 00:00:00