The increase in albuminuria induced by exercise is not associated with preferential excretion of glycated albumin in type 1 (insulin-dependent) diabetic patients.

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：:The aim of the present study was to elucidate the pathophysiologic significance of circulating ouabain as a link between insulin resistance (IR) and hypertension (HT) in NIDDM. Euglycaemic (4.5 mmol/l) hyperinsulinaemic (360-580 pmol/l) clamping was performed using an artificial endocrine pancreas. Plasma ouabain-like...

journal_title：Diabetologia

authors： Wasada T,Kuroki H,Naruse M,Arii H,Maruyama A,Katsumori K,Saito S,Watanabe Y,Naruse K,Demura H

更新日期：1995-07-01 00:00:00

abstract：:The capacity of reovirus type 3 to infect insulin-producing B cells was studied in human pancreatic cell cultures. Antibody to reovirus was labelled with fluorescein isothiocyanate and antibody to insulin was labelled with tetramethyl rhodamine isothiocyanate. By using a double-labelled immunofluorescent antibody tech...

journal_title：Diabetologia

authors： Yoon JW,Selvaggio S,Onodera T,Wheeler J,Jenson AB

更新日期：1981-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

journal_title：Diabetologia

authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

更新日期：2003-04-01 00:00:00

abstract：:Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, rece...

journal_title：Diabetologia

authors： McCreight LJ,Bailey CJ,Pearson ER

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

journal_title：Diabetologia

authors： Rozo AV,Vijayvargia R,Weiss HR,Ruan H

更新日期：2008-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...

journal_title：Diabetologia

authors： Icks A,Dickhaus T,Hörmann A,Heier M,Giani G,Kuch B,Meisinger C

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

journal_title：Diabetologia

authors： Ahmed M,Bergsten P

更新日期：2005-03-01 00:00:00

abstract：:The intraperitoneal route may offer more physiological insulin delivery through absorption of a proportion of the dose into the portal circulation. We have compared 1-h square-wave and bolus supplemental infusions of a fixed dose of 10 U of intraperitoneal insulin in 6 C-peptide negative insulin-dependent diabetic pat...

journal_title：Diabetologia

authors： Jimenez JT,Walford S,Home PD,Hanning I,Alberti KG

更新日期：1985-10-01 00:00:00

abstract：:Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 +/- 0.15 to 2.83 +/- 0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypogl...

journal_title：Diabetologia

authors： Bolli G,Calabrese G,De Feo P,Compagnucci P,Zega G,Angeletti G,Cartechini MG,Santeusanio F,Brunetti P

更新日期：1982-02-01 00:00:00

abstract：:Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

journal_title：Diabetologia

authors： Carré A,Richardson SJ,Larger E,Mallone R

更新日期：2021-01-01 00:00:00

abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

journal_title：Diabetologia

authors： Köbberling J,Brüggeboes B

更新日期：1980-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

journal_title：Diabetologia

authors： Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

更新日期：2008-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

journal_title：Diabetologia

authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

更新日期：2006-06-01 00:00:00

abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...

journal_title：Diabetologia

authors： Fontela T,Garcia Hermida O,Gómez-Acebo J

更新日期：1987-03-01 00:00:00

abstract：:Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....

journal_title：Diabetologia

authors： Hartter E,Svoboda T,Ludvik B,Schuller M,Lell B,Kuenburg E,Brunnbauer M,Woloszczuk W,Prager R

更新日期：1991-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the light of a report suggesting that insulin glargine may increase cancer occurrence, the EASD asked us to perform this study. METHODS:We followed 114,841 individuals who had a prescription dispensed for insulin between 1 July and 31 December 2005. From 1 January 2006 to 31 December 2007, we noted ...

journal_title：Diabetologia

authors： Jonasson JM,Ljung R,Talbäck M,Haglund B,Gudbjörnsdòttir S,Steineck G

更新日期：2009-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

journal_title：Diabetologia

authors： Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

更新日期：2013-10-01 00:00:00

abstract：:The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...

journal_title：Diabetologia

authors： Forrestel AC,Miedlich SU,Yurcheshen M,Wittlin SD,Sellix MT

更新日期：2018-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to explore the infancy growth trajectories of 'recent' and 'earlier' offspring of mothers with gestational diabetes mellitus (OGDM), each compared with the same control infants, and investigate whether 'recent' OGDM still exhibit a classical phenotype, with macrosomia and increased adip...

journal_title：Diabetologia

authors： Prentice PM,Olga L,Petry CJ,Simmons D,Murphy HR,Hughes IA,Acerini CL,Ong KK,Dunger DB

更新日期：2019-11-01 00:00:00

abstract：:The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...

journal_title：Diabetologia

authors： Bereiter DA,Rohner-Jeanrenaud F,Berthoud H-,Jeanrenaud B

更新日期：1981-03-01 00:00:00

abstract：:The concentration of biologically active insulin was measured by the isolated fat cell method in serum and urine from healthy subjects and compared with the concentration of immunoreactive insulin. In both urine and serum the values obtained by the two methods correlated closely; In addition, there was a close correla...

journal_title：Diabetologia

authors： El-Allawy RM,Sonne O,Gliemann J,Orskov H,Johansen K

更新日期：1976-10-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：:One of the reasons for the variability of blood glucose regulation in Type 1 (insulin-dependent) diabetic patients is the huge variation in subcutaneous absorption of intermediate-acting insulin. We have investigated the variation in insulin absorption during continuous subcutaneous insulin infusion in eight such pati...

journal_title：Diabetologia

authors： Lauritzen T,Pramming S,Deckert T,Binder C

更新日期：1983-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：:The symptoms caused by gastrointestinal autonomic neuropathy in diabetes mellitus is important to highlight since it affects a large proportion of people with diabetes, regardless of whether this is type 1 or type 2. Gastroparesis and general signs of bowel dysfunction, such as constipation, diarrhoea and abdominal pa...

journal_title：Diabetologia

authors： Törnblom H

更新日期：2016-03-01 00:00:00

abstract：:Multiple epidemiological studies have documented an association between metformin, used for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line models may not accurately reflect the effects of metformin in the clinical setting. Moreover, findings from animal model studies have been inco...

journal_title：Diabetologia

authors： Heckman-Stoddard BM,DeCensi A,Sahasrabuddhe VV,Ford LG

更新日期：2017-09-01 00:00:00

abstract：:Monolayer cell cultures from pancreatic islets of aging 129/J strain diabetes (db3J/db3J) and lean littermate control mice were tested for differences in glucagon and insulin secretion in either serum-free Eagle's minimal essential medium (MEM) or Dulbecco's modified minimal essential medium (DMEM). There was a highly...

journal_title：Diabetologia

authors： Leiter EH,Strack I,Eisenstein AB

更新日期：1980-07-01 00:00:00

abstract：:Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent in men than in women, especially in middle-aged populations. In line with this, considering almost all animal models, males are more likely to d...

journal_title：Diabetologia

authors： Tramunt B,Smati S,Grandgeorge N,Lenfant F,Arnal JF,Montagner A,Gourdy P

更新日期：2020-03-01 00:00:00

abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

journal_title：Diabetologia

authors： Herman JB,Medalie JH,Goldbourt U

更新日期：1977-05-01 00:00:00