The excretion of insulin in urine.

abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...

journal_title：Diabetologia

authors： Madsen KL,Ariano D,Fedorak RN

更新日期：1995-04-01 00:00:00

abstract：:The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...

journal_title：Diabetologia

authors： Gouédard HA,Ménez JF,Meskar A,Caroff J,Lucas D,Legendre JM

更新日期：1984-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...

journal_title：Diabetologia

authors： Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

更新日期：2005-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent ...

journal_title：Diabetologia

authors： Waller K,Kaprio J,Lehtovirta M,Silventoinen K,Koskenvuo M,Kujala UM

更新日期：2010-12-01 00:00:00

abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

journal_title：Diabetologia

authors： Migliorini A,Roscioni SS,Lickert H

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...

journal_title：Diabetologia

authors： Qu HQ,Marchand L,Grabs R,Polychronakos C

更新日期：2008-03-01 00:00:00

abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

journal_title：Diabetologia

authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

更新日期：1990-04-01 00:00:00

abstract：:The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...

journal_title：Diabetologia

authors： Dolais-Kitabgi J,Alengrin F,Freychet P

更新日期：1983-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

更新日期：2014-07-01 00:00:00

abstract：:The symptoms caused by gastrointestinal autonomic neuropathy in diabetes mellitus is important to highlight since it affects a large proportion of people with diabetes, regardless of whether this is type 1 or type 2. Gastroparesis and general signs of bowel dysfunction, such as constipation, diarrhoea and abdominal pa...

journal_title：Diabetologia

authors： Törnblom H

更新日期：2016-03-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：:New treatment strategies for subjects with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus are being developed. Pilot studies utilising insulin itself have been reported to prevent Type 1 diabetes in subjects likely, by immunogenetic and physiologic criteria, to develop clinically overt...

journal_title：Diabetologia

authors： Robertson RP,Klein DJ

更新日期：1992-12-01 00:00:00

abstract：:The influence of sex on pancreatic islet B cell susceptibility to streptozotocin was studied in mice given multiple low doses of streptozotocin. Male C3 D2 F1 mice developed a steadily increasing blood glucose level after a lag period of about 3 weeks, in contrast to females who were resistant. Spleen cells from strep...

journal_title：Diabetologia

authors： Kromann H,Christy M,Lernmark A,Nedergaard M,Nerup J

更新日期：1982-03-01 00:00:00

abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

journal_title：Diabetologia

authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

更新日期：1990-04-01 00:00:00

abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

journal_title：Diabetologia

authors： Hutton JC

更新日期：1994-09-01 00:00:00

abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

journal_title：Diabetologia

authors： Paisey RB,Harkness J,Hartog M,Chadwick T

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of...

journal_title：Diabetologia

authors： Koh HE,van Vliet S,Meyer GA,Laforest R,Gropler RJ,Klein S,Mittendorfer B

更新日期：2021-01-29 00:00:00

abstract：:The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...

journal_title：Diabetologia

authors： Pogátsa G,Dubecz E

更新日期：1977-09-01 00:00:00

abstract：:The systolic time intervals at rest of 16 Type 1 (insulin-dependent) and 30 Type 2 (non-insulin-dependent) otherwise healthy adult diabetic patients selected from primary health care clinics were compared with those of age- and sex-matched normal subjects by paired analysis. There was no significant difference in prev...

journal_title：Diabetologia

authors： Posner J,Ilya R,Wanderman K,Weitzman S

更新日期：1983-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought t...

journal_title：Diabetologia

authors： Shin SJ,Lai FJ,Wen JD,Hsiao PJ,Hsieh MC,Tzeng TF,Chen HC,Guh JY,Tsai JH

更新日期：2000-05-01 00:00:00

abstract：:It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

journal_title：Diabetologia

authors： Mallone R,Eizirik DL

更新日期：2020-10-01 00:00:00

abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

journal_title：Diabetologia

authors： Tomlinson DR

更新日期：1999-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...

journal_title：Diabetologia

authors： Babaei-Jadidi R,Karachalias N,Kupich C,Ahmed N,Thornalley PJ

更新日期：2004-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in ...

journal_title：Diabetologia

authors： Kusunoki M,Hara T,Tsutsumi K,Nakamura T,Miyata T,Sakakibara F,Sakamoto S,Ogawa H,Nakaya Y,Storlien LH

更新日期：2000-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine cell line. MATERIALS AND METHODS:GLP-1 release from GLUTag cells was measured in response to agents that increase cAMP, and single cells were studied by fluoresc...

journal_title：Diabetologia

authors： Simpson AK,Ward PS,Wong KY,Collord GJ,Habib AM,Reimann F,Gribble FM

更新日期：2007-10-01 00:00:00

abstract：:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DO...

journal_title：Diabetologia

authors： Grapin-Botton A,Seymour PA,Gradwohl G

更新日期：2015-05-01 00:00:00

abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Kerstens MN,Beusekamp BJ,De Jong PE,Dullaart RP,Navis GJ

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

journal_title：Diabetologia

authors： Ahmed M,Bergsten P

更新日期：2005-03-01 00:00:00