Abstract:
:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DOI: 10.1007/s00125-015-3507-x ) shines a spotlight on SOX4, revealing this factor to be a major player in the beta cell program. Using conditional inactivation in mice, they show that SOX4 shares some functions in progenitors with SOX9, but also plays a distinct role at a later stage of development, during the maturation of endocrine cells. This information is timely as this final maturation process is currently the most challenging to reproduce in vitro when coaxing pluripotent stem cells to convert into beta cells.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Grapin-Botton A,Seymour PA,Gradwohl Gdoi
10.1007/s00125-015-3539-2subject
Has Abstractpub_date
2015-05-01 00:00:00pages
859-61issue
5eissn
0012-186Xissn
1432-0428journal_volume
58pub_type
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