Neuronal and endothelial nitric oxide synthase expression in outer medulla of streptozotocin-induced diabetic rat kidney.

abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

journal_title：Diabetologia

authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...

journal_title：Diabetologia

authors： Kishore P,Kehlenbrink S,Hu M,Zhang K,Gutierrez-Juarez R,Koppaka S,El-Maghrabi MR,Hawkins M

更新日期：2012-06-01 00:00:00

abstract：AIMS:This prospective case-control study aimed at evaluating the time course of serum concentrations of soluble adhesion molecules; intercellular adhesion molecule-1 and L-selectin in siblings with signs of pre-clinical Type 1 diabetes in order to relate these concentrations to autoantibody status and to assess whether...

journal_title：Diabetologia

authors： Toivonen AM,Kulmala P,Savola K,Akerblom HK,Knip M

更新日期：2003-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the association of variants of the transcription factor 7-like 2 (TCF7L2) gene with: (1) incident diabetes in the Finnish Diabetes Prevention Study (DPS, Study I); (2) type 2 diabetes and impaired glucose regulation (i.e. IGT or IFG) in a cross-sectional study (Study II); and (3) insulin...

journal_title：Diabetologia

authors： Wang J,Kuusisto J,Vänttinen M,Kuulasmaa T,Lindström J,Tuomilehto J,Uusitupa M,Laakso M

更新日期：2007-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Numerous adaptations of the maternal immune system are necessary during pregnancy to maintain immunological tolerance to the semi-allogeneic fetus. Several complications of pregnancy have been associated with dysregulation of these adaptive mechanisms. While gestational diabetes mellitus (GDM) has been ...

journal_title：Diabetologia

authors： Sheu A,Chan Y,Ferguson A,Bakhtyari MB,Hawke W,White C,Chan YF,Bertolino PJ,Woon HG,Palendira U,Sierro F,Lau SM

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Platelet activation, endothelial dysfunction and inflammation may be involved in early stages of diabetic microangiopathy. We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matche...

journal_title：Diabetologia

authors： Yngen M,Östenson CG,Hu H,Li N,Hjemdahl P,Wallén NH

更新日期：2004-03-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...

journal_title：Diabetologia

authors： de Heer J,Pedersen J,Orskov C,Holst JJ

更新日期：2007-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...

journal_title：Diabetologia

authors： Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

更新日期：2015-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:A growing body of research suggests that the prevalence of major depressive disorder (MDD) in children and youth with type 1 diabetes mellitus is significantly higher than that of youth without type 1 diabetes and is associated with increased illness severity. The objective of this article is to review ...

journal_title：Diabetologia

authors： Korczak DJ,Pereira S,Koulajian K,Matejcek A,Giacca A

更新日期：2011-10-01 00:00:00

abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Kerstens MN,Beusekamp BJ,De Jong PE,Dullaart RP,Navis GJ

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of developing the disease. Given that early identification of these people is key for both primary and secondary prevention, new screening approaches are needed. Since spouses resemble each ...

journal_title：Diabetologia

authors： Nielsen J,Hulman A,Witte DR

更新日期：2018-07-01 00:00:00

abstract：:Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent in men than in women, especially in middle-aged populations. In line with this, considering almost all animal models, males are more likely to d...

journal_title：Diabetologia

authors： Tramunt B,Smati S,Grandgeorge N,Lenfant F,Arnal JF,Montagner A,Gourdy P

更新日期：2020-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...

journal_title：Diabetologia

authors： Bennett A,Sovio U,Ruokonen A,Martikainen H,Pouta A,Taponen S,Hartikainen AL,Franks S,Peltonen L,Elliott P,Järvelin MR,McCarthy MI

更新日期：2005-05-01 00:00:00

abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...

journal_title：Diabetologia

authors： Greaves M,Pickering C,Knight G,Boulton AJ,Ball J,Ward JD,Preston FE

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. METHODS:Patients (n = 17) with recent-onset diabetes clinically considered to be insulin dependent (Type I),...

journal_title：Diabetologia

authors： Imagawa A,Hanafusa T,Itoh N,Waguri M,Yamamoto K,Miyagawa J,Moriwaki M,Yamagata K,Iwahashi H,Sada M,Tsuji T,Tamura S,Kawata S,Kuwajima M,Nakajima H,Namba M,Matsuzawa Y

更新日期：1999-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...

journal_title：Diabetologia

authors： Cho YM,Kim TH,Lim S,Choi SH,Shin HD,Lee HK,Park KS,Jang HC

更新日期：2009-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations. No studies to date have investig...

journal_title：Diabetologia

authors： Bulman MP,Harries LW,Hansen T,Shepherd M,Kelly WF,Hattersley AT,Ellard S

更新日期：2002-10-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the...

journal_title：Diabetologia

authors： Siitonen N,Pulkkinen L,Mager U,Lindström J,Eriksson JG,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Laakso M,Uusitupa M

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...

journal_title：Diabetologia

authors： Tura A,Chemello G,Szendroedi J,Göbl C,Færch K,Vrbíková J,Pacini G,Ferrannini E,Roden M

更新日期：2018-05-01 00:00:00

abstract：:A recent investigation of families containing two and three consecutive generations affected with Type I (insulin dependent) diabetes mellitus has led to speculation that there is a second susceptibility gene, not linked to the major histocompatibility complex. These families differ in important respects from families...

journal_title：Diabetologia

authors： Suarez BK,Van Eerdewegh P

更新日期：1981-05-01 00:00:00

abstract：:Mitochondrial DNA is maternally inherited. Mitochondrial DNA mutations could contribute to the excess of maternal over paternal inheritance of non-insulin-dependent diabetes mellitus (NIDDM). We therefore investigated the relationship between this variant, insulin resistance and other risk factors in a cohort which ha...

journal_title：Diabetologia

authors： Poulton J,Brown MS,Cooper A,Marchington DR,Phillips DI

更新日期：1998-01-01 00:00:00

abstract：AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...

journal_title：Diabetologia

authors： Sansbury FH,Flanagan SE,Houghton JA,Shuixian Shen FL,Al-Senani AM,Habeb AM,Abdullah M,Kariminejad A,Ellard S,Hattersley AT

更新日期：2012-09-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

journal_title：Diabetologia

authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

更新日期：2000-02-01 00:00:00

abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

journal_title：Diabetologia

authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

更新日期：1996-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

journal_title：Diabetologia

authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

更新日期：2012-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:Type 1 diabetes is an immune-mediated disease leading to almost total beta cell destruction and permanent exogenous insulin dependency. The appearance of clinical symptoms is preceded by an asymptomatic preclinical period, the duration of which is highly individual. The emergence of diabetes-associated autoantibodies ...

journal_title：Diabetologia

authors： Knip M,Selvenius J,Siljander H,Veijola R

更新日期：2017-01-01 00:00:00