Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.


AIMS/HYPOTHESIS:Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the association of ADIPOR1 gene variations with body size and risk of type 2 diabetes in subjects with impaired glucose tolerance, who participated in the Finnish Diabetes Prevention Study (DPS). SUBJECTS AND METHODS:We selected seven single nucleotide polymorphisms (SNPs) of the ADIPOR1 gene to perform association studies with anthropometrics and metabolic parameters at baseline, and with the risk of type 2 diabetes during the 3-year follow-up in the DPS study population. Both single SNP analysis and haplotype effects were studied. RESULTS:Three out of seven markers studied (rs10920534, rs22757538 and rs1342387) were significantly associated with various body size measurements including weight, height, waist and hip circumference, sagittal diameter and body mass index. Furthermore, three markers (rs10920534, rs12045862 and rs7539542), of which two were different from those associating with body size, were linked to fasting and 2-h insulin levels, particularly in men at baseline. The haplotype analysis with five markers revealed seven major haplotypes in the DPS study population. The haplotype effects on body size measures were in line with those of single SNP analysis. However, none of the markers were associated with the risk of type 2 diabetes. CONCLUSIONS/INTERPRETATION:Our findings suggest that ADIPOR1 has a putative role in the development of body size, and that traits for central adiposity and insulin resistance may be dissociated from each other.






Siitonen N,Pulkkinen L,Mager U,Lindström J,Eriksson JG,Valle TT,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Tuomilehto J,Laakso M,Uusitupa M




Has Abstract


2006-08-01 00:00:00












  • Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland.

    abstract:AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...


    pub_type: 杂志文章


    authors: Malik MO,Govan L,Petrie JR,Ghouri N,Leese G,Fischbacher C,Colhoun H,Philip S,Wild S,McCrimmon R,Sattar N,Lindsay RS,Scottish Diabetes Research Network Epidemiology Group.

    更新日期:2015-04-01 00:00:00

  • The contribution of naturally labelled 13C fructose to glucose appearance in humans.

    abstract::Among monosaccharides, fructose has a small hyperglycaemic effect. In order to better explain the mechanisms which cause this metabolic property, we used tracers labelled with stable isotopes (deuterated glucose and naturally 13C labelled fructose) to quantify the overall glucose appearance, the rate of appearance in ...


    pub_type: 杂志文章


    authors: Delarue J,Normand S,Pachiaudi C,Beylot M,Lamisse F,Riou JP

    更新日期:1993-04-01 00:00:00

  • Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

    abstract::Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...


    pub_type: 杂志文章


    authors: Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

    更新日期:1987-12-01 00:00:00

  • Potassium intake and risk of incident type 2 diabetes mellitus: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract:AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...


    pub_type: 杂志文章


    authors: Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

    更新日期:2012-05-01 00:00:00

  • Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirub

    abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) is a risk factor for perinatal complications. In several countries, the criteria for the diagnosis of GDM have been in flux, the American Diabetes Association (ADA) thresholds recommended in 2000 being lower than those of the National Diabetes Data Group (NDDG) that h...


    pub_type: 杂志文章


    authors: Ferrara A,Weiss NS,Hedderson MM,Quesenberry CP Jr,Selby JV,Ergas IJ,Peng T,Escobar GJ,Pettitt DJ,Sacks DA

    更新日期:2007-02-01 00:00:00

  • Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats.

    abstract:AIMS/HYPOTHESIS:Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-depend...


    pub_type: 杂志文章


    authors: Chang TJ,Chen WP,Yang C,Lu PH,Liang YC,Su MJ,Lee SC,Chuang LM

    更新日期:2009-06-01 00:00:00

  • Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.

    abstract:AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yki-Järvinen H,Kauppinen-Mäkelin R,Tiikkainen M,Vähätalo M,Virtamo H,Nikkilä K,Tulokas T,Hulme S,Hardy K,McNulty S,Hänninen J,Levänen H,Lahdenperä S,Lehtonen R,Ryysy L

    更新日期:2006-03-01 00:00:00

  • Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index.

    abstract:AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...


    pub_type: 杂志文章


    authors: Tura A,Chemello G,Szendroedi J,Göbl C,Færch K,Vrbíková J,Pacini G,Ferrannini E,Roden M

    更新日期:2018-05-01 00:00:00

  • The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.

    abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...


    pub_type: 杂志文章


    authors: de Heer J,Pedersen J,Orskov C,Holst JJ

    更新日期:2007-10-01 00:00:00

  • Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population-based cross-sectional study.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...


    pub_type: 杂志文章


    authors: Tillin T,Forouhi N,Johnston DG,McKeigue PM,Chaturvedi N,Godsland IF

    更新日期:2005-04-01 00:00:00

  • Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells.

    abstract::Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...


    pub_type: 杂志文章


    authors: Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

    更新日期:1998-12-01 00:00:00

  • Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.

    abstract:AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...


    pub_type: 临床试验,杂志文章


    authors: Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

    更新日期:2011-10-01 00:00:00

  • The AGE product N epsilon-(carboxymethyl)lysine serum albumin is a modulator of proteoglycan expression in polarized cultured kidney epithelial cells.

    abstract:AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...


    pub_type: 杂志文章


    authors: Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

    更新日期:2001-04-01 00:00:00

  • Complications in IDDM are caused by elevated blood glucose level: the Stockholm Diabetes Intervention Study (SDIS) at 10-year follow up.

    abstract::Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reichard P,Pihl M,Rosenqvist U,Sule J

    更新日期:1996-12-01 00:00:00

  • Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

    abstract:AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...


    pub_type: 杂志文章


    authors: Lorenzo C,Hanley AJ,Haffner SM

    更新日期:2014-01-01 00:00:00

  • The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.

    abstract:AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...


    pub_type: 杂志文章


    authors: Strey CH,Young J,Collier M,Florkowski CM,Shand BI,Scott RS

    更新日期:2004-10-01 00:00:00

  • Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

    abstract::It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...


    pub_type: 杂志文章,评审


    authors: Mallone R,Eizirik DL

    更新日期:2020-10-01 00:00:00

  • Amelioration of nerve conduction velocity following simultaneous kidney/pancreas transplantation is due to the glycaemic control provided by the pancreas.

    abstract::Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debat...


    pub_type: 杂志文章


    authors: Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

    更新日期:1997-09-01 00:00:00

  • Proteomic characterisation reveals active Wnt-signalling by human multipotent stromal cells as a key regulator of beta cell survival and proliferation.

    abstract:AIMS/HYPOTHESIS:Novel strategies to stimulate the expansion of beta cell mass in situ are warranted for diabetes therapy. The aim of this study was to elucidate the secretome of human bone marrow (BM)-derived multipotent stromal cells (MSCs) with documented islet regenerative paracrine function. We hypothesised that re...


    pub_type: 杂志文章


    authors: Kuljanin M,Bell GI,Sherman SE,Lajoie GA,Hess DA

    更新日期:2017-10-01 00:00:00

  • Glucose inhibits replication of cultured human endothelial cells.

    abstract::Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...


    pub_type: 杂志文章


    authors: Stout RW

    更新日期:1982-11-01 00:00:00

  • Effect of acute hyperglycaemia on plasma potassium and aldosterone levels in type 2 (non-insulin-dependent) diabetes.

    abstract::Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...


    pub_type: 杂志文章


    authors: Rosenstock J,Loizou SA,Brajkovich IE,Mashiter K,Joplin GF

    更新日期:1982-03-01 00:00:00

  • Blood flow in the diabetic neuropathic foot.

    abstract::The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...


    pub_type: 杂志文章


    authors: Edmonds ME,Roberts VC,Watkins PJ

    更新日期:1982-01-01 00:00:00

  • Basal insulin glargine and microvascular outcomes in dysglycaemic individuals: results of the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial.

    abstract:AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...


    pub_type: 杂志文章,随机对照试验


    authors: ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

    更新日期:2014-07-01 00:00:00

  • Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering type 1 (insulin-dependent) diabetic children.

    abstract::Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Drummond K,Levy-Marchal C,Laborde K,Kindermans C,Wright C,Dechaux M,Czernichow P

    更新日期:1989-04-01 00:00:00

  • Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...


    pub_type: 杂志文章


    authors: Berger AP,Deibl M,Halpern EJ,Lechleitner M,Bektic J,Horninger W,Fritsche G,Steiner H,Pelzer A,Bartsch G,Frauscher F

    更新日期:2005-04-01 00:00:00

  • Metformin and the gastrointestinal tract.

    abstract::Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, rece...


    pub_type: 杂志文章,评审


    authors: McCreight LJ,Bailey CJ,Pearson ER

    更新日期:2016-03-01 00:00:00

  • Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.

    abstract:AIMS/HYPOTHESIS:The purpose of this study was to assess the therapeutic implication of leptin in insulin-deficient diabetes. METHODS:Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. Plasma concentrations of glucose, insulin, and leptin were measured. The e...


    pub_type: 杂志文章


    authors: Miyanaga F,Ogawa Y,Ebihara K,Hidaka S,Tanaka T,Hayashi S,Masuzaki H,Nakao K

    更新日期:2003-10-01 00:00:00

  • A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles.

    abstract::The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...


    pub_type: 杂志文章


    authors: Chiu KC,Province MA,Dowse GK,Zimmet PZ,Wagner G,Serjeantson S,Permutt MA

    更新日期:1992-07-01 00:00:00

  • Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study.

    abstract:AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...


    pub_type: 杂志文章


    authors: Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

    更新日期:2020-07-01 00:00:00

  • Identification and analysis of murine pancreatic islet enhancers.

    abstract:AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...


    pub_type: 杂志文章


    authors: Tennant BR,Robertson AG,Kramer M,Li L,Zhang X,Beach M,Thiessen N,Chiu R,Mungall K,Whiting CJ,Sabatini PV,Kim A,Gottardo R,Marra MA,Lynn FC,Jones SJ,Hoodless PA,Hoffman BG

    更新日期:2013-03-01 00:00:00