当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.

Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.

Abstract：

AIMS/HYPOTHESIS:The purpose of this study was to assess the therapeutic implication of leptin in insulin-deficient diabetes. METHODS:Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. Plasma concentrations of glucose, insulin, and leptin were measured. The effects on body weight, food intake, and hypothalamic gene expressions were analyzed. After diabetes was induced, graded doses of insulin ranging from 0.4 to 51.2 mU.g(-1).day(-1) were injected. Co-administration of leptin and insulin was also carried out using osmotic pumps. RESULTS:After STZ injection, both transgenic and non-transgenic littermates developed marked hyperglycaemia as a result of severe hypoinsulinaemia [termed diabetic transgenic skinny mice overexpressing leptin (diabetic TGM) and diabetic non-transgenic littermates (diabetic WT) respectively], although diabetic TGM were more sensitive to exogenously administered insulin than diabetic WT. Diabetic WT were hypoleptinaemic and hyperphagic relative to non-diabetic WT, whereas diabetic TGM, which remained hyperleptinaemic, were less hyperphagic than diabetic WT. After STZ injection, hypothalamic expressions of orexigenic and anorexigenic peptide mRNAs were up-regulated and down-regulated, respectively, in diabetic WT, whereas they were unchanged in diabetic TGM. Diabetic TGM became normoglycaemic, when treated with insulin at such doses that did not improve hyperglycaemia in diabetic WT. We found that a sub-threshold dose of insulin that does not affect glucose homeostasis is effective in improving the diabetes in normal mice rendered diabetic by STZ injection, when combined with leptin. CONCLUSIONS/INTERPRETATION:This study suggests that leptin could be used as an adjunct of insulin therapy in insulin-deficient diabetes, thereby providing an insight into the therapeutic implication of leptin as an anti-diabetic agent.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Miyanaga F,Ogawa Y,Ebihara K,Hidaka S,Tanaka T,Hayashi S,Masuzaki H,Nakao K

doi

10.1007/s00125-003-1193-6

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1329-37

issue

10

eissn

0012-186X

issn

1432-0428

journal_volume

46

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-001-0769-2

    authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

    更新日期：2002-03-01 00:00:00

  • Preserved C-peptide secretion is associated with fewer low-glucose events and lower glucose variability on flash glucose monitoring in adults with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05099-3

    authors： Gibb FW,McKnight JA,Clarke C,Strachan MWJ

    更新日期：2020-05-01 00:00:00

  • Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome.

    abstract：:Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However...

    journal_title：Diabetologia

    pub_type： 社论

    doi：10.1007/s00125-017-4306-3

    authors： Sam S,Ehrmann DA

    更新日期：2017-09-01 00:00:00

  • Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis.

    abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00125-007-0884-9

    authors： Golicki DT,Golicka D,Groele L,Pankowska E

    更新日期：2008-02-01 00:00:00

  • Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study.

    abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2312-4

    authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

    更新日期：2012-01-01 00:00:00

  • Calcium-antagonists and islet function. IV. Effect of D600.

    abstract：:D600 (2 to 20 muM; alpha-isopropyl-alpha [(N-methyl-N-homoveratril)-gamma-aminopropyl]-3,4,5-trimethoxyphenyl-acetonitril) caused a dose-related, rapid and reversible inhibition of glucose-induced insulin release. It also suppressed the insulinotropic action of a sulphonylurea but failed to affect the enhancing action...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01221969

    authors： Malaisse WJ,Devis G,Pipeleers DG,Somers G

    更新日期：1976-03-01 00:00:00

  • Factors controlling pancreatic cell differentiation and function.

    abstract：:Diabetes affects 4 to 5% of the population worldwide and is the most common metabolic disorder. The number of individuals diagnosed with diabetes is rapidly increasing, especially in the developed countries and the disorder frequently leads to secondary complications such as retinopathy, nephropathy, neuropathy and ca...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s001250100623

    authors： Edlund H

    更新日期：2001-09-01 00:00:00

  • Ciglitazone, a new hypoglycaemic agent. 3. Effect on glucose disposal and gluconeogenesis in vivo in C57BL/6J-ob/ob and -+/? mice.

    abstract：:Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00284462

    authors： Chang AY,Gilchrist BJ,Wyse BM

    更新日期：1983-12-01 00:00:00

  • Elevated GLUT 1 level in crude muscle membranes from diabetic Zucker rats despite a normal GLUT 1 level in perineurial sheaths.

    abstract：:Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050130

    authors： Handberg A,Kayser L,Høyer PE,Micheelsen J,Vinten J

    更新日期：1994-05-01 00:00:00

  • The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats.

    abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00399794

    authors： Cameron NE,Dines KC,Cotter MA

    更新日期：1994-12-01 00:00:00

  • Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend.

    abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1606-2

    authors： Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

    更新日期：2010-03-01 00:00:00

  • The influence of maternal glucose metabolism on fetal growth, development and morbidity in 917 singleton pregnancies in nondiabetic women.

    abstract：:To study the effects on the fetus of variations in maternal glucose tolerance, a 25 g rapid intravenous glucose tolerance test was performed at or about 32 weeks gestation in 917 randomly selected nondiabetic women with singleton pregnancies. The results were withheld from the patients and their obstetricians and paed...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00276845

    authors： Farmer G,Russell G,Hamilton-Nicol DR,Ogenbede HO,Ross IS,Pearson DW,Thom H,Kerridge DF,Sutherland HW

    更新日期：1988-03-01 00:00:00

  • Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4404-2

    authors： Dawed AY,Ali A,Zhou K,Pearson ER,Franks PW

    更新日期：2017-11-01 00:00:00

  • Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring.

    abstract：:Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00428777

    authors： Boucher BJ,Ewen SW,Stowers JM

    更新日期：1994-01-01 00:00:00

  • The effect of hyperglycaemia on pancreatic islets transplanted into rats beneath the kidney capsule.

    abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00274254

    authors： Gray DW,Cranston D,McShane P,Sutton R,Morris PJ

    更新日期：1989-09-01 00:00:00

  • The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. METHODS:We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the ye...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0033-2

    authors： Knerr I,Wolf J,Reinehr T,Stachow R,Grabert M,Schober E,Rascher W,Holl RW,DPV Scientific Initiative of Germany and Austria.

    更新日期：2005-12-01 00:00:00

  • Beta-cell cytoplasmic Ca2+ balance as a determinant for glucose-stimulated insulin release.

    abstract：:The introduction of new techniques and the access to clonal lines of insulin-secreting cells have enabled re-evaluation of glucose effects on Ca2+ movements in pancreatic beta cells. It became evident that glucose, in addition to stimulating the entry of Ca2+, also promotes active sequestration of the ion in intracell...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281983

    authors： Hellman B

    更新日期：1985-08-01 00:00:00

  • Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trøndelag Health Survey.

    abstract：AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051248

    authors： Forsén L,Meyer HE,Midthjell K,Edna TH

    更新日期：1999-08-01 00:00:00

  • The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0865-z

    authors： Sparsø T,Andersen G,Nielsen T,Burgdorf KS,Gjesing AP,Nielsen AL,Albrechtsen A,Rasmussen SS,Jørgensen T,Borch-Johnsen K,Sandbaek A,Lauritzen T,Madsbad S,Hansen T,Pedersen O

    更新日期：2008-01-01 00:00:00

  • Renal proteinases and kidney hypertrophy in experimental diabetes.

    abstract：:IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00403374

    authors： Schaefer L,Schaefer RM,Ling H,Teschner M,Heidland A

    更新日期：1994-06-01 00:00:00

  • Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension.

    abstract：:Recent studies have suggested an association between a deletion (D) variant of the angiotensin-converting-enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension,...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050662

    authors： Ringel J,Beige J,Kunz R,Distler A,Sharma AM

    更新日期：1997-02-01 00:00:00

  • Genetic associations in diabetic nephropathy: a meta-analysis.

    abstract：AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00125-010-1996-1

    authors： Mooyaart AL,Valk EJ,van Es LA,Bruijn JA,de Heer E,Freedman BI,Dekkers OM,Baelde HJ

    更新日期：2011-03-01 00:00:00

  • Current perception thresholds: a new, quick, and reproducible method for the assessment of peripheral neuropathy in diabetes mellitus.

    abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00274531

    authors： Masson EA,Veves A,Fernando D,Boulton AJ

    更新日期：1989-10-01 00:00:00

  • The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS).

    abstract：AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-012-2741-8

    authors： Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJ

    更新日期：2013-01-01 00:00:00

  • Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation.

    abstract：AIMS/HYPOTHESIS:Diabetic distal symmetrical sensory polyneuropathy (DSP) affects 20-30% of diabetic patients. Transcutaneous electrical nerve stimulation (TENS) and electrical spinal cord stimulation have been proposed as physical therapies. We performed a controlled, randomised pilot trial to compare the effects of hi...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00125-005-1728-0

    authors： Reichstein L,Labrenz S,Ziegler D,Martin S

    更新日期：2005-05-01 00:00:00

  • Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4.

    abstract：:In pancreatic lesions of non-obese diabetic (NOD) mice the expression of inducible nitric oxide synthase (iNOS) and of the cytokines interferon-gamma and interleukin-4 were studied. Strong iNOS expression as determined at the level of transcription, translation and of enzyme activity was associated with destructive in...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00418380

    authors： Rothe H,Faust A,Schade U,Kleemann R,Bosse G,Hibino T,Martin S,Kolb H

    更新日期：1994-11-01 00:00:00

  • A prospective study of mortality among middle-aged diabetic patients (the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics) I: Causes and death rates.

    abstract：:The 497 members of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics have been followed for mortality from 1975 to 1987. During this period 92 patients died. The most common cause of death was myocardial infarction: 36 (39.1%) deaths, heart disease was responsible for 51.1% of deaths an...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00404141

    authors： Morrish NJ,Stevens LK,Head J,Fuller JH,Jarrett RJ,Keen H

    更新日期：1990-09-01 00:00:00

  • Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.

    abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4260-0

    authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

    更新日期：2017-06-01 00:00:00

  • Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Microvascular complications in the heart and kidney are strongly associated with an overall rise in inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory molecule that limits and resolves inflammation. In this study, we have used a bedside to bench approach to investigate: (1) ANXA1 levels...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4469-y

    authors： Purvis GSD,Chiazza F,Chen J,Azevedo-Loiola R,Martin L,Kusters DHM,Reutelingsperger C,Fountoulakis N,Gnudi L,Yaqoob MM,Collino M,Thiemermann C,Solito E

    更新日期：2018-02-01 00:00:00

  • Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP.

    abstract：:Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00403961

    authors： Reynet C,Kahn CR,Loeken MR

    更新日期：1996-02-01 00:00:00