Abstract:
AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-aged men. METHODS:The subjects, 99 healthy 50-year-old men with an apolipoprotein E3/3 genotype, ate a mixed meal. The apolipoprotein B-48 and B-100 contents were determined in triglyceride-rich lipoproteins as a measure of chylomicron remnant and very low density lipoprotein particle concentrations. RESULTS:Fasting plasma insulin was associated with the triglyceride response to the test meal, independently of body mass index, waist-to-hip circumference ratio, blood glucose and the insulin effect on fasting plasma triglycerides. Exaggerated and prolonged postprandial lipaemia in subjects in the upper quartile of the plasma insulin distribution was largely accounted for by large (Svedberg flotation rate > 60) very low density lipoproteins and chylomicron remnants. Insulin relations to large postprandial triglyceride-rich lipoproteins exclusively reflected the association between plasma insulin and the fasting plasma concentrations of these lipoprotein species, whereas plasma insulin and late postprandial plasma concentrations of small (Svedberg flotation rate 20-60) chylomicron remnants were related, independently of insulin influences on fasting concentrations. Strong positive relations were found between the late increases in large triglyceride-rich lipoproteins and plasma non-esterified fatty acid concentrations after 6 h. CONCLUSION/INTERPRETATION:The degree of insulin sensitivity is a major determinant of postprandial lipaemia in healthy middle-aged men and could add to the regulation of the basal production of large triglyceride-rich lipoproteins.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Boquist S,Hamsten A,Karpe F,Ruotolo Gdoi
10.1007/s001250050028subject
Has Abstractpub_date
2000-02-01 00:00:00pages
185-93issue
2eissn
0012-186Xissn
1432-0428journal_volume
43pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::We have previously reported that oxygen free radical scavengers protect rat islet cells from damage by cytokines and we interpreted these findings as suggesting the involvement of oxygen free radicals but did not directly measure indices of free radical activity. In this study, we report on malondialdehyde, an end pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02342435
更新日期:1992-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s001250100571
更新日期:2001-07-01 00:00:00
abstract::Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283750
更新日期:1982-03-01 00:00:00
abstract::The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253862
更新日期:1982-01-01 00:00:00
abstract::The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00297455
更新日期:1989-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2193-6
更新日期:2011-08-01 00:00:00
abstract::Family and twin studies have shown clearly that Type I (insulin-dependent) diabetes mellitus has a genetic basis. However, only within the past decade has it been possible to systematically attempt to identify the genes that increase susceptibility to this disorder using linkage and association analysis of genetic mar...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s125-002-8241-7
更新日期:2002-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4260-0
更新日期:2017-06-01 00:00:00
abstract::A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00405010
更新日期:1991-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1582-5
更新日期:2004-12-01 00:00:00
abstract::The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404072
更新日期:1993-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1969-4
更新日期:2011-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sig...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3697-2
更新日期:2015-10-01 00:00:00
abstract::The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274531
更新日期:1989-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rate-limiting defect. Recently, the plant-derived sugar a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2527-z
更新日期:2012-06-01 00:00:00
abstract::The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253494
更新日期:1984-07-01 00:00:00
abstract::Major histocompatibility complex-linked immune response genes are thought to influence susceptibility to induction of both human insulin-dependent diabetes and murine streptozotocin-induced diabetes. To clarify this relationship, we administered streptozotocin intravenously in two doses (120 and 240 mg/kg body weight)...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00275678
更新日期:1984-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1619-x
更新日期:2010-03-01 00:00:00
abstract::IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403374
更新日期:1994-06-01 00:00:00
abstract::Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00290484
更新日期:1980-01-01 00:00:00
abstract::Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-002-0975-6
更新日期:2002-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Interleukin-1beta is a putative mediator of pancreatic beta-cell dysfunction and damage in Type I (insulin-dependent) diabetes mellitus. To better understand the molecular mechanisms involved in IL-1beta effects, we carried out a differential display of mRNA by RT-PCR to identify novel cytokine-regulate...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051292
更新日期:1999-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1204-8
更新日期:2009-02-01 00:00:00
abstract::To investigate the presence of autoantibodies against sympathetic nervous tissue and their correlation with cardiac sympathetic dysinnervation in insulin-dependent diabetes mellitus (IDDM), 20 newly diagnosed (age 26 +/- 6 years) and 48 long-term IDDM patients (age 40 +/- 13 years, duration of diabetes 22 +/- 12 years...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403917
更新日期:1996-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperinsulinaemia and insulin resistance, as well as low IGF-I, have been implicated in the pathogenesis of cardiovascular disease. Little is known about direct effects of IGF-I and insulin on human coronary artery smooth muscle cells (HCASMCs). Our aim was to characterise the expression and function of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1890-4
更新日期:2005-10-01 00:00:00
abstract::Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1420-x
更新日期:2009-10-01 00:00:00
abstract::Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403323
更新日期:1990-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051248
更新日期:1999-08-01 00:00:00
abstract::The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00277416
更新日期:1988-05-01 00:00:00
abstract::In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404643
更新日期:1990-06-01 00:00:00