Abstract:
:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated control subjects have developed diabetes, whereas only 1 of 14 treated children has diabetes to date. This data suggests that nicotinamide has an effect in preventing Type 1 (insulin-dependent) diabetes and that randomized controlled studies are now indicated.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Elliott RB,Chase HPdoi
10.1007/BF00405010subject
Has Abstractpub_date
1991-05-01 00:00:00pages
362-5issue
5eissn
0012-186Xissn
1432-0428journal_volume
34pub_type
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