Abstract:
AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observational study using healthcare databases from Ontario, Canada. All Ontario residents 30 years of age or older free of cancer and diabetes between 1 January 1996 and 31 December 2015 were eligible for inclusion. Using Cox regression analyses, we explored the association between diabetes and the risk and mortality of haematological malignancies (leukaemia, lymphoma, multiple myeloma). The impact of timing on associations was evaluated with analyses stratified by time since diabetes diagnosis (<3 months, 3 months to 1 year, ≥1 year). RESULTS:We identified 1,003,276 individuals with diabetes and age and sex matched these to 2,006,552 individuals without diabetes. Compared with individuals without diabetes, those with diabetes had a modest but significantly higher risk of a haematological malignancy (adjusted HR 1.10 [95% CI 1.08, 1.12] p < 0.0001). This association persisted across all time periods since diabetes diagnosis. Among those with haematological malignancies, diabetes was associated with a higher all-cause mortality (HR 1.36 [95% CI 1.31, 1.41] p < 0.0001) compared with no diabetes, as well as cause-specific mortality. CONCLUSIONS/INTERPRETATION:Diabetes is associated with a higher risk of haematological malignancies and is an independent risk factor of all-cause and cause-specific mortality. Greater efforts for lifestyle modification may not only reduce diabetes burden and its complications but may also potentially lower risk of malignancy and mortality. Graphical abstract.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LLdoi
10.1007/s00125-020-05338-7subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-020-05338-7pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400997
更新日期:1991-09-01 00:00:00
abstract::Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-021-05380-z
更新日期:2021-01-26 00:00:00
abstract::Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00290590
更新日期:1988-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1810-7
更新日期:2005-08-01 00:00:00
abstract::Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283750
更新日期:1982-03-01 00:00:00
abstract::Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051072
更新日期:1998-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test if exogenous FGF21 is sufficient to prevent diabetes and beta cell loss in New Zealand o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4389-x
更新日期:2017-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0354-9
更新日期:2006-09-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Previous studies have implicated the glycoxidative modification of low-density lipoprotein (LDL) by glucose and aldehydes (apparently comprising both glycation and oxidation), as a causative factor in the elevated levels of atherosclerosis observed in diabetic patients. Such LDL modification can result ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1648-4
更新日期:2005-02-01 00:00:00
abstract::Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00295878
更新日期:1987-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function were investigated. MATERIALS AND METHODS:INS-1 stable cell lines permitting inducible up- or downregulation of this transcription factor were...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0490-2
更新日期:2007-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3492-0
更新日期:2015-04-01 00:00:00
abstract::MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...
journal_title:Diabetologia
pub_type: 评论,社论
doi:10.1007/s00125-017-4213-7
更新日期:2017-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3568-x
更新日期:2015-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. METHODS:The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05301-6
更新日期:2021-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4834-0
更新日期:2019-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of developing the disease. Given that early identification of these people is key for both primary and secondary prevention, new screening approaches are needed. Since spouses resemble each ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4587-1
更新日期:2018-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The effects of successful pancreas transplant alone (PTA) on chronic complications of diabetes, in particular diabetic retinopathy, remain disputed. We prospectively studied the course of diabetic retinopathy in PTA recipients and in non-transplanted (non-PTA) type 1 diabetic patients. METHODS:The PTA ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0463-5
更新日期:2006-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1689-3
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1618-y
更新日期:2010-03-01 00:00:00
abstract::Since glucose control and glycosylated haemoglobin varies asyncroneously, we have studied the steady-state relationship between these two factors. In Type 1 (insulin-dependent) diabetic patients with a constant haemoglobin A1c during the preceding 2 years, 15 ambulatory blood glucose profiles during a 5-week period sh...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00260951
更新日期:1982-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Levels of ideal cardiovascular health (ICH) and incident type 2 diabetes mellitus have not been examined in a multiethnic population. We assessed the total and race/ethnicity-specific incidence of diabetes based on American Heart Association (AHA) ICH components. METHODS:Incident diabetes was assessed ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4003-7
更新日期:2016-09-01 00:00:00
abstract::Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050968
更新日期:1998-06-01 00:00:00
abstract::46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279926
更新日期:1985-02-01 00:00:00
abstract::Loss of neurogenic inflammation in response to tissue injury may be an important complication of diabetes mellitus. We studied local neurogenic inflammation in the peripheral nerve trunk of Sprague-Dawley rats 4 months following the induction of diabetes by streptozotocin injection. To assess neurogenic inflammation, ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02743263
更新日期:1993-06-01 00:00:00
abstract::In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before th...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-006-0232-5
更新日期:2006-06-01 00:00:00
abstract::The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF03216225
更新日期:1981-07-01 00:00:00