Abstract:
AIMS/HYPOTHESIS:In the UK, more than one million people have undiagnosed diabetes and an additional five million are at high risk of developing the disease. Given that early identification of these people is key for both primary and secondary prevention, new screening approaches are needed. Since spouses resemble each other in cardiometabolic risk factors related to type 2 diabetes, we aimed to investigate whether diabetes and cardiometabolic risk factors in one spouse can be used as an indicator of incident type 2 diabetes in the other spouse. METHODS:We analysed data from 3649 men and 3478 women from the English Longitudinal Study of Ageing with information on their own and their spouse's diabetes status and cardiometabolic risk factors. We modelled incidence rates and incidence rate ratios with Poisson regression, using spousal diabetes status or cardiometabolic risk factors (i.e. BMI, waist circumference, systolic and diastolic BP, HDL- and LDL-cholesterol and triacylglycerols) as exposures and type 2 diabetes incidence in the index individual as the outcome. Models were adjusted for two nested sets of covariates. RESULTS:Spousal BMI and waist circumference were associated with incident type 2 diabetes, but with different patterns for men and women. A man's risk of type 2 diabetes increased more steeply with his wife's obesity level, and the association remained statistically significant even after adjustment for the man's own obesity level. Having a wife with a 5 kg/m2 higher BMI (30 kg/m2 vs 25 kg/m2) was associated with a 21% (95% CI 11%, 33%) increased risk of type 2 diabetes. In contrast, the association between incident type 2 diabetes in a woman and her husband's BMI was attenuated after adjusting for the woman's own obesity level. Findings for waist circumference were similar to those for BMI. Regarding other risk factors, we found a statistically significant association only between the risk of type 2 diabetes in women and their husbands' triacylglycerol levels. CONCLUSIONS/INTERPRETATION:The main finding of this study is the sex-specific effect of spousal obesity on the risk of type 2 diabetes. Having an obese spouse increases an individual's risk of type 2 diabetes over and above the effect of the individual's own obesity level among men, but not among women. Our results suggest that a couples-focused approach may be beneficial for the early detection of type 2 diabetes and individuals at high risk of developing type 2 diabetes, especially in men, who are less likely than women to attend health checks. DATA AVAILABILITY:Data were accessed via the UK Data Service under the data-sharing agreement no. 91400 ( https://discover.ukdataservice.ac.uk/catalogue/?sn=5050&type=Data%20catalogue ).
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Nielsen J,Hulman A,Witte DRdoi
10.1007/s00125-018-4587-1subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1572-1580issue
7eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-018-4587-1journal_volume
61pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::In this study, we found that the ratio of proinsulin to total immunoreactive insulin was much higher in 22 patients with Type 2 (non-insulin-dependent) diabetes mellitus than in 28 non-diabetic control subjects of similar age and adiposity (32 +/- 3 vs 15 +/- 1%, p less than 0.001). In addition, the arginine-induced a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00296991
更新日期:1987-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4082-5
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05376-1
更新日期:2021-01-30 00:00:00
abstract::The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-calle...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3611-y
更新日期:2015-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3006-x
更新日期:2013-11-01 00:00:00
abstract::The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257344
更新日期:1983-06-01 00:00:00
abstract::Epidemiologic data suggest that having a parent with Type 2 (non-insulin-dependent) diabetes mellitus increases the risk for Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 diabetes and Type 2 diabetes...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00405008
更新日期:1991-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3807-1
更新日期:2016-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100615
更新日期:2001-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4750-8
更新日期:2019-01-01 00:00:00
abstract::Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) an...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00410287
更新日期:1995-04-01 00:00:00
abstract::To investigate the mechanism whereby changes in plasma glucose level alter human pancreatic A-cell activity in vivo, A-cell activity was determined during manipulation of plasma glucose and pancreatic B-cell activity by insulin and glucose infusions. A-cell activity (the acute immunoreactive glucagon response to intra...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00252408
更新日期:1984-03-01 00:00:00
abstract::Insulin resistance of the skeletal muscle plays a key role in the development of the metabolic endocrine syndrome and its further progression to non-insulin dependent diabetes (NIDDM). Available data suggest that insulin resistance is caused by an impaired signal from the insulin receptor to the glucose transport syst...
journal_title:Diabetologia
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/BF00400838
更新日期:1994-09-01 00:00:00
abstract::The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00270425
更新日期:1987-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0631-2
更新日期:2007-06-01 00:00:00
abstract::Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223020
更新日期:1978-05-01 00:00:00
abstract::The antiprotozoal drug pentamidine can be toxic to islet cells in vivo and in vitro. Rat islets were exposed to pentamidine (mesylate and isethionate salts) and six other structurally related diamidines. The beta-cell response to arginine + theophylline was suppressed by pentamidine (10(-2) mmol/l) while the glucagon ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283144
更新日期:1985-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine cell line. MATERIALS AND METHODS:GLP-1 release from GLUTag cells was measured in response to agents that increase cAMP, and single cells were studied by fluoresc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0750-9
更新日期:2007-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4880-7
更新日期:2019-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The intestine is the main site for glucose absorption and it has been suggested that it exhibits insulin resistance. Bariatric surgery has been shown to reverse insulin resistance and type 2 diabetes, but its effects on human intestinal metabolism are unknown. Our aim was to evaluate the effects of insu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3501-3
更新日期:2015-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3230-z
更新日期:2014-07-01 00:00:00
abstract::There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2513-5
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Delivery of the gene for human vascular endothelial growth factor (VEGF, also known as VEGFA) to both the transplanted islets and the surrounding tissue may promote islet revascularisation and survival. We previously showed the effective delivery of VEGF gene to rat myocardium by an ultrasound-mediated ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1745-5
更新日期:2010-08-01 00:00:00
abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050751
更新日期:1997-07-01 00:00:00
abstract::Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274225
更新日期:1987-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Adiponectin is a circulating peptide derived from adipose tissue. It mediates its insulin-sensitising and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2. Our aim was to study the...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-006-0291-7
更新日期:2006-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051647
更新日期:2001-04-01 00:00:00
abstract::Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00262209
更新日期:1984-06-01 00:00:00
abstract::We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00403384
更新日期:1994-06-01 00:00:00