Abstract:
:Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bicarbonate, amylase and trypsin were measured. Exocrine secretory pancreatic function was decreased in 14 patients. Fasting and maximal CPR showed that 9 patients had residual insulin secretion. For these 'CPR-secretors' there was a strong correlation between CPR and output of bicarbonate (r = 0.87, p less than 0.005) and amylase (r = 0.7, p less than 0.05), but not with trypsin. These results suggest the existence of an endocrine-exocrine relationship in the pancreas.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Frier BM,Faber OK,Binder C,Elliot HLdoi
10.1007/BF01223020subject
Has Abstractpub_date
1978-05-01 00:00:00pages
301-4issue
5eissn
0012-186Xissn
1432-0428journal_volume
14pub_type
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