The effect of residual insulin secretion on exocrine pancreatic function in juvenile-onset diabetes mellitus.

Abstract:

:Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bicarbonate, amylase and trypsin were measured. Exocrine secretory pancreatic function was decreased in 14 patients. Fasting and maximal CPR showed that 9 patients had residual insulin secretion. For these 'CPR-secretors' there was a strong correlation between CPR and output of bicarbonate (r = 0.87, p less than 0.005) and amylase (r = 0.7, p less than 0.05), but not with trypsin. These results suggest the existence of an endocrine-exocrine relationship in the pancreas.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Frier BM,Faber OK,Binder C,Elliot HL

doi

10.1007/BF01223020

subject

Has Abstract

pub_date

1978-05-01 00:00:00

pages

301-4

issue

5

eissn

0012-186X

issn

1432-0428

journal_volume

14

pub_type

杂志文章
  • Risk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4.

    abstract::To test the hypothesis that interaction between genetic, immunological, clinical and metabolic risk factors influences the outcome of Type II (non-insulin-dependent) diabetes mellitus, we examined which of the above factors present at baseline were associated with mortality in 134 Type II diabetic patients followed fo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051062

    authors: Forsblom CM,Sane T,Groop PH,Tötterman KJ,Kallio M,Saloranta C,Laasonen L,Summanen P,Lepäntalo M,Laatikainen L,Matikainen E,Teppo AM,Koskimies S,Groop L

    更新日期:1998-11-01 00:00:00

  • γ-Glutamyltransferase, but not markers of hepatic fibrosis, is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the Edinburgh Type 2 Diabetes Study.

    abstract:AIMS/HYPOTHESIS:We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship between these two important conditions. METHODS:1,066 participants with type 2 diabetes aged 60-...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-015-3575-y

    authors: Morling JR,Fallowfield JA,Williamson RM,Robertson CM,Glancy S,Guha IN,Strachan MW,Price JF

    更新日期:2015-07-01 00:00:00

  • Can targeting ANGPTL proteins improve glucose tolerance?

    abstract::Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

    journal_title:Diabetologia

    pub_type: 评论,杂志文章

    doi:10.1007/s00125-018-4604-4

    authors: Davies BSJ

    更新日期:2018-06-01 00:00:00

  • Cellular basis of direct insulin action in the central nervous system.

    abstract::The in vivo radioautographic method has been applied to elucidate the mechanism of direct peptide hormone "feedback" action in the CNS. Using this method we have identified the circumventricular organs of the brain as general endocrine target tissues for a variety of blood-borne polypeptide hormones, including insulin...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00254491

    authors: van Houten M,Posner BI

    更新日期:1981-03-01 00:00:00

  • Diabetes: the genetic connections.

    abstract::Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/BF01236266

    authors: Pyke DA

    更新日期:1979-12-01 00:00:00

  • Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus.

    abstract::We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400253

    authors: Kowluru A,Kowluru RA,Yamazaki A

    更新日期:1992-07-01 00:00:00

  • Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus.

    abstract::Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400276

    authors: Jenkins D,Penny MA,Mijovic CH,Jacobs KH,Fletcher J,Barnett AH

    更新日期:1991-08-01 00:00:00

  • Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.

    abstract:AIM/HYPOTHESIS:A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We ai...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-006-0477-z

    authors: van Vliet-Ostaptchouk JV,Shiri-Sverdlov R,Zhernakova A,Strengman E,van Haeften TW,Hofker MH,Wijmenga C

    更新日期:2007-01-01 00:00:00

  • Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-016-4190-2

    authors: Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

    更新日期:2017-03-01 00:00:00

  • Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

    abstract::Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01221952

    authors: Henquin JC,Malvaux P,Lambert AE

    更新日期:1979-04-01 00:00:00

  • Cloning of human pancreatic islet large conductance Ca(2+)-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker.

    abstract::Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00403907

    authors: Ferrer J,Wasson J,Salkoff L,Permutt MA

    更新日期:1996-08-01 00:00:00

  • Regression of albuminuria and its association with incident cardiovascular outcomes and mortality in type 1 diabetes: the FinnDiane Study.

    abstract:AIMS/HYPOTHESIS:Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes. METHODS:The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individu...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-018-4564-8

    authors: Jansson FJ,Forsblom C,Harjutsalo V,Thorn LM,Wadén J,Elonen N,Ahola AJ,Saraheimo M,Groop PH,FinnDiane Study Group.

    更新日期:2018-05-01 00:00:00

  • Depression as a risk factor for dementia in older people with type 2 diabetes and the mediating effect of inflammation.

    abstract:AIMS/HYPOTHESIS:We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. METHODS:The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05301-6

    authors: Carr AL,Sluiman AJ,Grecian SM,Forster R,McLachlan S,Strachan MWJ,Price JF

    更新日期:2021-02-01 00:00:00

  • Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the gen...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0700-6

    authors: Itoi-Babaya M,Ikegami H,Fujisawa T,Ueda H,Nojima K,Babaya N,Kobayashi M,Noso S,Kawaguchi Y,Yamaji K,Shibata M,Ogihara T

    更新日期:2007-08-01 00:00:00

  • Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring.

    abstract:AIMS/HYPOTHESIS:We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. METHODS:The research was carried out within the Diabetes Prediction and Prevention...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-010-1734-8

    authors: Marjamäki L,Niinistö S,Kenward MG,Uusitalo L,Uusitalo U,Ovaskainen ML,Kronberg-Kippilä C,Simell O,Veijola R,Ilonen J,Knip M,Virtanen SM

    更新日期:2010-08-01 00:00:00

  • Early insulin release following suckling in neonatal lambs and rabbits.

    abstract::Developmental changes in the plasma insulin response to milk ingestion have been determined in neonatal lambs fed by bottle and in naturally suckled infant rabbits. In lambs at 4 days of age and older plasma insulin increased within 5 min of suckling and declined again before increasing to a second peak 60 to 120 min ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01219799

    authors: Porter RJ,Bassett JM

    更新日期:1979-03-01 00:00:00

  • Racial and ethnic disparities in extremes of fetal growth after gestational diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to assess and compare risks of having large- or small-for gestational age (LGA and SGA, respectively) infants born to women with gestational diabetes mellitus (GDM) from ten racial/ethnic groups. METHODS:LGA and SGA were defined as birthweight >90th and <10th percentile, respe...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3420-8

    authors: Xiang AH,Black MH,Li BH,Martinez MP,Sacks DA,Lawrence JM,Buchanan TA,Jacobsen SJ

    更新日期:2015-02-01 00:00:00

  • Pentamidine, a new diabetogenic drug in laboratory rodents.

    abstract::The antiprotozoal drug, pentamidine, has been reported to induce hypoglycaemia associated with inappropriately high plasma insulin concentrations, followed by insulin-dependent diabetes mellitus. It has been suggested that this drug can be toxic to the islet B cell, inducing early cytolytic release of insulin leading ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00282521

    authors: Saï P,Boillot D,Boitard C,Debray-Sachs M,Reach G,Assan R

    更新日期:1983-11-01 00:00:00

  • Expression of insulin regulatable glucose transporters in skeletal muscle from type 2 (non-insulin-dependent) diabetic patients.

    abstract::A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400207

    authors: Handberg A,Vaag A,Damsbo P,Beck-Nielsen H,Vinten J

    更新日期:1990-10-01 00:00:00

  • Dysregulation of glucose transport in hearts of genetically obese (fa/fa) rats.

    abstract::Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose metabolism were decreased in hearts of 15-week-old obese rats when compared to lean age-matched controls. Basa...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00284464

    authors: Zaninetti D,Crettaz M,Jeanrenaud B

    更新日期:1983-12-01 00:00:00

  • Secular trend for mortality from breast cancer and the association between diabetes and breast cancer in Taiwan between 1995 and 2006.

    abstract:AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-1204-8

    authors: Tseng CH,Chong CK,Tai TY

    更新日期:2009-02-01 00:00:00

  • Receptor binding and biological effect of insulin in human adipocytes.

    abstract::The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01236312

    authors: Andersen O,Gliemann J,Gammeltoft S

    更新日期:1977-12-01 00:00:00

  • Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3163-6

    authors: Kallas-Koeman MM,Kong JM,Klinke JA,Butalia S,Lodha AK,Lim KI,Duan QM,Donovan LE

    更新日期:2014-04-01 00:00:00

  • Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.

    abstract::It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400672

    authors: Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

    更新日期:1996-04-01 00:00:00

  • Plasma corticosterone concentrations in diabetic (db) mice.

    abstract::Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00996323

    authors: Coleman DL,Burkart DL

    更新日期:1977-01-01 00:00:00

  • SGLT inhibitor adjunct therapy in type 1 diabetes.

    abstract::Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this approach is, however, scant and few pharmacological agents have proved effective enough to become part of routine clinical care. Recent short-term P...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-018-4671-6

    authors: McCrimmon RJ,Henry RR

    更新日期:2018-10-01 00:00:00

  • The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes.

    abstract:AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250100615

    authors: Isomaa B,Henricsson M,Almgren P,Tuomi T,Taskinen MR,Groop L

    更新日期:2001-09-01 00:00:00

  • The effect of improvement in diabetic control on plasma and whole blood viscosity.

    abstract::Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00280518

    authors: Paisey RB,Harkness J,Hartog M,Chadwick T

    更新日期:1980-10-01 00:00:00

  • Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.

    abstract::In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00420977

    authors: Gotfredsen CF

    更新日期:1976-08-01 00:00:00

  • Cardiovascular risk assessment scores for people with diabetes: a systematic review.

    abstract::People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-009-1454-0

    authors: Chamnan P,Simmons RK,Sharp SJ,Griffin SJ,Wareham NJ

    更新日期:2009-10-01 00:00:00