Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay.

abstract：:Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...

journal_title：Diabetologia

authors： Betterle C,Zanette F,Pedini B,Presotto F,Rapp LB,Monciotti CM,Rigon F

更新日期：1984-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The 1997 American Diabetes Association classification of diabetes mellitus included a subset of Type I diabetic patients who do not need insulin for several years but eventually progress to complete insulin deficiency i. e. atypical Type I diabetes mellitus. In Caucasian populations, most Type I diabeti...

journal_title：Diabetologia

authors： Lee WJ,Lee HW,Palmer JP,Park KS,Lee HK,Park JY,Hong SK,Lee KU

更新日期：2001-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition. METHODS:We performed...

journal_title：Diabetologia

authors： Bugianesi E,Gastaldelli A,Vanni E,Gambino R,Cassader M,Baldi S,Ponti V,Pagano G,Ferrannini E,Rizzetto M

更新日期：2005-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：:We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...

journal_title：Diabetologia

authors： Plater ME,Ford I,Dent MT,Preston FE,Ward JD

更新日期：1996-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-spe...

journal_title：Diabetologia

authors： Mezghenna K,Leroy J,Azay-Milhau J,Tousch D,Castex F,Gervais S,Delgado-Betancourt V,Gross R,Lajoix AD

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...

journal_title：Diabetologia

authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

更新日期：2014-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined in skeletal muscle (1) whether fatty acid transport protein (FATP) 1 channels long-chain fatty acid (LCFA) to specific metabolic fates in rats; and (2) whether FATP1-mediated increases in LCFA uptake exacerbate the development of diet-induced insulin resistance in mice. We also examined whet...

journal_title：Diabetologia

authors： Holloway GP,Chou CJ,Lally J,Stellingwerff T,Maher AC,Gavrilova O,Haluzik M,Alkhateeb H,Reitman ML,Bonen A

更新日期：2011-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:As vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial to treat diabetic retinopathy. HGF (hepatocyte growth factor)/NK4, containing the N-terminal hairpin domain and the four subsequent kringle ...

journal_title：Diabetologia

authors： Nakabayashi M,Morishita R,Nakagami H,Kuba K,Matsumoto K,Nakamura T,Tano Y,Kaneda Y

更新日期：2003-01-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...

journal_title：Diabetologia

authors： Malik MO,Govan L,Petrie JR,Ghouri N,Leese G,Fischbacher C,Colhoun H,Philip S,Wild S,McCrimmon R,Sattar N,Lindsay RS,Scottish Diabetes Research Network Epidemiology Group.

更新日期：2015-04-01 00:00:00

abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...

journal_title：Diabetologia

authors： Nirantharakumar K,Mohammed N,Toulis KA,Thomas GN,Narendran P

更新日期：2018-07-01 00:00:00

abstract：:This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...

journal_title：Diabetologia

authors： Ellis MJ,Darby SC,Jones RH,Sönksen PH

更新日期：1978-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...

journal_title：Diabetologia

authors： Koffler M,Imamura T,Santeusanio F,Helderman JH

更新日期：1988-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of e...

journal_title：Diabetologia

authors： Gangadhariah MH,Dieckmann BW,Lantier L,Kang L,Wasserman DH,Chiusa M,Caskey CF,Dickerson J,Luo P,Gamboa JL,Capdevila JH,Imig JD,Yu C,Pozzi A,Luther JM

更新日期：2017-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

journal_title：Diabetologia

authors： Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

更新日期：2021-01-01 00:00:00

abstract：:The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentrations during the OGTT, were measured in 10 patients with duodenal ulcer and in 10 healthy control subjects. The m...

journal_title：Diabetologia

authors： Lauritsen KB,Moody AJ

更新日期：1978-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...

journal_title：Diabetologia

authors： Siemelink M,Verhoef A,Dormans JA,Span PN,Piersma AH

更新日期：2002-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to assess the role of coronary artery calcification (CAC) and its progression in predicting incident coronary artery disease (CAD) in individuals with type 1 diabetes using data from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. METHODS:The present study examined 292 part...

journal_title：Diabetologia

authors： Guo J,Erqou SA,Miller RG,Edmundowicz D,Orchard TJ,Costacou T

更新日期：2019-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

journal_title：Diabetologia

authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

更新日期：2004-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to analyse how strongly commuting and leisure-time physical activity affect progression to diabetes and to study whether this relationship is different in individuals with isolated impaired fasting glucose (i-IFG) and isolated impaired glucose tolerance (i-IGT). METHODS:We stud...

journal_title：Diabetologia

authors： Engberg S,Glümer C,Witte DR,Jørgensen T,Borch-Johnsen K

更新日期：2010-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:This long-term study was designed to further characterise the retinal safety profile of insulin glargine and human neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes mellitus. METHODS:An open-label, 5 year, randomised (1:1), multicentre, stratified, parallel-group study conducted...

journal_title：Diabetologia

authors： Rosenstock J,Fonseca V,McGill JB,Riddle M,Hallé JP,Hramiak I,Johnston P,Davis M

更新日期：2009-09-01 00:00:00

abstract：:The introduction of new techniques and the access to clonal lines of insulin-secreting cells have enabled re-evaluation of glucose effects on Ca2+ movements in pancreatic beta cells. It became evident that glucose, in addition to stimulating the entry of Ca2+, also promotes active sequestration of the ion in intracell...

journal_title：Diabetologia

authors： Hellman B

更新日期：1985-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...

journal_title：Diabetologia

authors： Freedman BI,Hsu FC,Langefeld CD,Rich SS,Herrington DM,Carr JJ,Xu J,Bowden DW,Wagenknecht LE

更新日期：2005-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

journal_title：Diabetologia

authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

更新日期：2006-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...

journal_title：Diabetologia

authors： Yu DX,Sun Q,Ye XW,Pan A,Zong G,Zhou YH,Li HX,Hu FB,Lin X

更新日期：2012-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent ...

journal_title：Diabetologia

authors： Waller K,Kaprio J,Lehtovirta M,Silventoinen K,Koskenvuo M,Kujala UM

更新日期：2010-12-01 00:00:00