Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates.

abstract：AIM/HYPOTHESIS:Oxidative stress was shown to selectively induce impaired metabolic response to insulin, raising the possible involvement of alterations in Insulin-Receptor-Substrate (IRS) proteins. This study was conducted to assess whether oxidative stress induced IRS protein degradation and enhanced serine phosphoryl...

journal_title：Diabetologia

authors： Potashnik R,Bloch-Damti A,Bashan N,Rudich A

更新日期：2003-05-01 00:00:00

abstract：:This study aimed at verifying whether thiamine, a co-enzyme which decreases intracellular glycolysis metabolites by allowing pyruvate and glyceraldheyde 3-phosphate to enter the Krebs cycle and the pentose-phosphate shunt, respectively, corrects delayed replication caused by high glucose concentrations in cultured hum...

journal_title：Diabetologia

authors： La Selva M,Beltramo E,Pagnozzi F,Bena E,Molinatti PA,Molinatti GM,Porta M

更新日期：1996-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Satellite cells are responsible for postnatal skeletal muscle regeneration. It has been demonstrated that mouse satellite cells behave as multipotent stem cells. We studied the differentiation capacities of human satellite cells and evaluated the effect of the insulin sensitiser rosiglitazone, a well kn...

journal_title：Diabetologia

authors： De Coppi P,Milan G,Scarda A,Boldrin L,Centobene C,Piccoli M,Pozzobon M,Pilon C,Pagano C,Gamba P,Vettor R

更新日期：2006-08-01 00:00:00

abstract：:Insulin secretion was stimulated and cyclic adenosine 3', 5'-monophosphate (cAMP) levels were elevated in isolated rat islets by 27.5 mmol/l glucose. Alloxan caused a dose-dependent decrease in both variables with complete obliteration of insulin release at a concentration of 1.25 mmol/l. D-glucose, in the presence or...

journal_title：Diabetologia

authors： Zawalich WS,Karl RC,Matschinsky FM

更新日期：1979-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...

journal_title：Diabetologia

authors： Bobbioni-Harsch E,Sztajzel J,Barthassat V,Lehmann TN,Sievert K,Chassot G,Huber O,Morel P,Golay A,Assimacopoulos-Jeannet F

更新日期：2005-07-01 00:00:00

abstract：:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...

journal_title：Diabetologia

authors： Wilding JP,Khandan-Nia N,Bennet WM,Gilbey SG,Beacham J,Ghatei MA,Bloom SR

更新日期：1994-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Interleukin-1beta is a putative mediator of pancreatic beta-cell dysfunction and damage in Type I (insulin-dependent) diabetes mellitus. To better understand the molecular mechanisms involved in IL-1beta effects, we carried out a differential display of mRNA by RT-PCR to identify novel cytokine-regulate...

journal_title：Diabetologia

authors： Chen MC,Schuit F,Eizirik DL

更新日期：1999-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is re...

journal_title：Diabetologia

authors： Not T,Tommasini A,Tonini G,Buratti E,Pocecco M,Tortul C,Valussi M,Crichiutti G,Berti I,Trevisiol C,Azzoni E,Neri E,Torre G,Martelossi S,Soban M,Lenhardt A,Cattin L,Ventura A

更新日期：2001-02-01 00:00:00

abstract：:QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...

journal_title：Diabetologia

authors： Ewing DJ,Boland O,Neilson JM,Cho CG,Clarke BF

更新日期：1991-03-01 00:00:00

abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

journal_title：Diabetologia

authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

更新日期：1997-07-01 00:00:00

abstract：:Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

journal_title：Diabetologia

authors： Carré A,Richardson SJ,Larger E,Mallone R

更新日期：2021-01-01 00:00:00

abstract：:We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

更新日期：1984-03-01 00:00:00

abstract：:The Neurometer is a variable constant current sine wave stimulator, and has recently been proposed as a simple non-invasive and quantitative measure of peripheral nerve function. The device is portable and battery operated; assessment of upper and lower extremities takes only a few min, in contrast to conventional ass...

journal_title：Diabetologia

authors： Masson EA,Veves A,Fernando D,Boulton AJ

更新日期：1989-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional s...

journal_title：Diabetologia

authors： Perez-Alcantara M,Honoré C,Wesolowska-Andersen A,Gloyn AL,McCarthy MI,Hansson M,Beer NL,van de Bunt M

更新日期：2018-07-01 00:00:00

abstract：:Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...

journal_title：Diabetologia

authors： Foulis AK,Farquharson MA,Cameron SO,McGill M,Schönke H,Kandolf R

更新日期：1990-05-01 00:00:00

abstract：:In a prospective study concerning the pathogenesis of impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetes mellitus, 346 subjects with no clinical history of diabetes were given a standard 75 g oral glucose tolerance test. The expected positive associations between 120-min plasma glucose concentratio...

journal_title：Diabetologia

authors： Brown DC,Byrne CD,Clark PM,Cox BD,Day NE,Hales CN,Shackleton JR,Wang TW,Williams DR

更新日期：1991-07-01 00:00:00

abstract：:We investigated whether the glomerular synthesis of prostaglandins modulates the glomerular filtration rate and albuminuria in diabetic nephropathy. The urinary excretion of immunoreactive prostaglandin E2 (253 pg/min) was significantly elevated in eight Type 1 (insulin-dependent) diabetic women with nephropathy as co...

journal_title：Diabetologia

authors： Hommel E,Mathiesen E,Arnold-Larsen S,Edsberg B,Olsen UB,Parving HH

更新日期：1987-02-01 00:00:00

abstract：:The global nutrition transition, which embraces major changes in how food is produced, distributed and consumed, is associated with rapid increases in the prevalence of obesity, but the implications for diabetes differ between populations. A simple conceptual model treats diabetes risk as the function of two interacti...

journal_title：Diabetologia

authors： Wells JCK

更新日期：2019-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...

journal_title：Diabetologia

authors： Ellard S,Bellanné-Chantelot C,Hattersley AT,European Molecular Genetics Quality Network (EMQN) MODY group.

更新日期：2008-04-01 00:00:00

abstract：:The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...

journal_title：Diabetologia

authors： Bader S,Scholz R,Kellerer M,Tippmer S,Rett K,Mathaei S,Freund P,Häring HU

更新日期：1992-08-01 00:00:00

abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

journal_title：Diabetologia

authors： Köbberling J,Brüggeboes B

更新日期：1980-06-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：:Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debat...

journal_title：Diabetologia

authors： Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

更新日期：1997-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Acute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair gluco...

journal_title：Diabetologia

authors： Kehlenbrink S,Koppaka S,Martin M,Relwani R,Cui MH,Hwang JH,Li Y,Basu R,Hawkins M,Kishore P

更新日期：2012-11-01 00:00:00

abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

journal_title：Diabetologia

authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

更新日期：1990-04-01 00:00:00

abstract：:A recent report has shown an association between a specific Xba1 restriction fragment of the human HepG2-Erythrocyte glucose transporter gene and Type 2 (non-insulin dependent) diabetes. To further examine the significance of this finding we have studied Type 2 diabetic pedigrees for linkage between the Xba1 alleles o...

journal_title：Diabetologia

authors： O'Rahilly S,Patel P,Wainscoat JS,Turner RC

更新日期：1989-04-01 00:00:00

abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

journal_title：Diabetologia

authors： Shaw JE

更新日期：2017-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...

journal_title：Diabetologia

authors： Bathula R,Hughes AD,Panerai R,Potter J,Thom SA,Francis DP,Shore AC,Kooner J,Chaturvedi N

更新日期：2010-10-01 00:00:00