当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Amelioration of nerve conduction velocity following simultaneous kidney/pancreas transplantation is due to the glycaemic control provided by the pancreas.

Amelioration of nerve conduction velocity following simultaneous kidney/pancreas transplantation is due to the glycaemic control provided by the pancreas.

Abstract：

:Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debate. Nerve conduction velocity (NCV) was assessed before and after simultaneous pancreas and kidney transplantation, and before and after pancreas graft failure in five insulin-dependent diabetic (IDDM) patients affected by severe diabetic polyneuropathy. Sensory and motor NCV were recorded in five nerves and expressed as a cumulative index for each patient. Metabolic control was evaluated by fasting blood glucose and glycosylated haemoglobin levels. NCV index was below normal values before transplant: -3.8 +/- 0.7 (normal value: 0.89), improved 1 and 2 years after transplant: -3.1 +/- 1.3 and -2.6 +/- 0.9 (p = 0.0019), stabilised until pancreas failure and deteriorated to pre-transplant values 2 years after pancreas graft failure: -3.6 +/- 1.0 (p = 0.034). Fasting blood glucose levels worsened after pancreas graft failure. HbA1c levels, in the normal range during functioning pancreas graft (6.6 +/- 0.6%), deteriorated after its failure (8.0 +/- 0.6%, p = 0.04). Kidney function was preserved. These data support a positive effect of pancreas transplantation per se on NCV in IDDM subjects with diabetic polyneuropathy, thus demonstrating that metabolic control provided by a self-regulated source of insulin not only halts but also ameliorates nerve function, even if polyneuropathy is advanced.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Martinenghi S,Comi G,Galardi G,Di Carlo V,Pozza G,Secchi A

doi

10.1007/s001250050795

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

1110-2

issue

9

eissn

0012-186X

issn

1432-0428

journal_volume

40

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Metal-activated C-peptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT1 transporter.

    abstract：AIMS/HYPOTHESIS:Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production. METHODS:Erythrocy...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0853-3

    authors： Meyer JA,Froelich JM,Reid GE,Karunarathne WK,Spence DM

    更新日期：2008-01-01 00:00:00

  • Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011.

    abstract：AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2805-9

    authors： Lau X,Zhang Y,Kelly DJ,Stapleton DI

    更新日期：2013-03-01 00:00:00

  • The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes.

    abstract：AIMS/HYPOTHESIS:We examined features of the metabolic syndrome to see if they modified the risk of chronic diabetic complications in patients with Type II (non-insulin-dependent) diabetes mellitus. METHODS:A total of 85 randomly selected patients with the metabolic syndrome (WHO definition) were compared with 85 Type ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250100615

    authors： Isomaa B,Henricsson M,Almgren P,Tuomi T,Taskinen MR,Groop L

    更新日期：2001-09-01 00:00:00

  • Resistance to tolerance induction in the diabetes-prone biobreeding rat as one manifestation of abnormal responses to superantigens.

    abstract：:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had b...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400410

    authors： Sellins KS,Gold DP,Bellgrau D

    更新日期：1996-01-01 00:00:00

  • Association of blood glucose control and pancreatic reserve with diabetic retinopathy in the Veterans Affairs Diabetes Trial (VADT).

    abstract：AIMS/HYPOTHESIS:The aim of this study was to test the hypothesis that intensive glycaemic control (INT) and higher plasma C-peptide levels in patients with poorly controlled diabetes would be associated with better eye outcomes. METHODS:The incidence and progression of diabetic retinopathy (DR) was assessed by grading...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-014-3199-7

    authors： Azad N,Agrawal L,Emanuele NV,Klein R,Bahn GD,Reaven P,VADT Study Group.

    更新日期：2014-06-01 00:00:00

  • Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases.

    abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

    journal_title：Diabetologia

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1007/BF00400826

    authors： Hutton JC

    更新日期：1994-09-01 00:00:00

  • Glucose regulates both glucose transport and the glucose transporter gene expression in a hamster-derived pancreatic beta-cell line (HIT).

    abstract：:We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l glucose for 48 h and then glucose transport was studied by measuring the (3H)-2-deoxyglucose uptake for 5 and...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00405011

    authors： Purrello F,Buscema M,Vetri M,Vinci C,Gatta C,Forte F,Rabuazzo AM,Vigneri R

    更新日期：1991-05-01 00:00:00

  • Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications.

    abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1710-x

    authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

    更新日期：2005-05-01 00:00:00

  • Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0912-9

    authors： Achenbach P,Bonifacio E,Williams AJ,Ziegler AG,Gale EA,Bingley PJ,ENDIT Group.

    更新日期：2008-03-01 00:00:00

  • Elevated GLUT 1 level in crude muscle membranes from diabetic Zucker rats despite a normal GLUT 1 level in perineurial sheaths.

    abstract：:Recently, we demonstrated that approximately 60% of GLUT 1 in a crude membrane fraction of rat skeletal muscle originates from perineurial sheaths. To study the in vivo regulation of GLUT 1 expression in different tissues in muscles, we measured the level of GLUT 1 in crude muscle membranes and in perineurial sheaths ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050130

    authors： Handberg A,Kayser L,Høyer PE,Micheelsen J,Vinten J

    更新日期：1994-05-01 00:00:00

  • Glycated albumin but not HbA1c reflects glycaemic control in patients with neonatal diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2211-8

    authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

    更新日期：2011-09-01 00:00:00

  • Risk stratification systems for diabetic foot ulcers: a systematic review.

    abstract：AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-010-2030-3

    authors： Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

    更新日期：2011-05-01 00:00:00

  • Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in amyloidogenesis.

    abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050751

    authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

    更新日期：1997-07-01 00:00:00

  • [Not Available].

    abstract：:Oral (o.GTT) and intravenous glucose tolerance tests (i.v. GTT) were carried out on 492 patients of both sexes, aged from 5 to 78 years. Three hundred and fifty-nine non-diabetics in all were suspected clinically of reduced carbohydrate tolerance leaving 133 patients for comparison (controls). In 102 obesity was noted...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01257910

    authors： Schilling WH,Oberdisse K,Hüter KA,Blank H

    更新日期：1966-04-01 00:00:00

  • Delay of type I diabetes in high risk, first degree relatives by parenteral antigen administration: the Schwabing Insulin Prophylaxis Pilot Trial.

    abstract：:The Schwabing Insulin Prophylaxis Trial is a randomised, controlled pilot study designed to examine whether insulin therapy can delay or prevent the clinical onset of Type I diabetes in high risk first degree relatives of people with the disease. First degree relatives of patients with Type I diabetes, who were aged 4...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001250050943

    authors： Füchtenbusch M,Rabl W,Grassl B,Bachmann W,Standl E,Ziegler AG

    更新日期：1998-05-01 00:00:00

  • A new mutation (db3J) at the diabetes locus in strain 129/J mice. II. Studies of pancreatic alpha cell function in culture.

    abstract：:Monolayer cell cultures from pancreatic islets of aging 129/J strain diabetes (db3J/db3J) and lean littermate control mice were tested for differences in glucagon and insulin secretion in either serum-free Eagle's minimal essential medium (MEM) or Dulbecco's modified minimal essential medium (DMEM). There was a highly...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00258314

    authors： Leiter EH,Strack I,Eisenstein AB

    更新日期：1980-07-01 00:00:00

  • The influence of the ACE ( I/D) polymorphism on systemic and renal vascular responses to angiotensins in normotensive, normoalbuminuric Type 1 diabetes mellitus.

    abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1149-x

    authors： Luik PT,Hoogenberg K,Kerstens MN,Beusekamp BJ,De Jong PE,Dullaart RP,Navis GJ

    更新日期：2003-08-01 00:00:00

  • Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05218-0

    authors： Van Hove I,De Groef L,Boeckx B,Modave E,Hu TT,Beets K,Etienne I,Van Bergen T,Lambrechts D,Moons L,Feyen JHM,Porcu M

    更新日期：2020-10-01 00:00:00

  • The ultrastructure of polyploid B-cells in the islets of normal mice.

    abstract：:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00428985

    authors： Bowen RE,Swartz FJ

    更新日期：1976-05-01 00:00:00

  • The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy.

    abstract：AIMS/HYPOTHESIS:Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-010-1943-1

    authors： Zhou T,Zhou KK,Lee K,Gao G,Lyons TJ,Kowluru R,Ma JX

    更新日期：2011-02-01 00:00:00

  • Salivary insulin concentrations in type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects: relationship to changes in plasma insulin levels after an oral glucose load.

    abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00870278

    authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

    更新日期：1986-10-01 00:00:00

  • The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.

    abstract：AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-013-3149-9

    authors： Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

    更新日期：2014-05-01 00:00:00

  • The renal metabolism of insulin.

    abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/BF00304849

    authors： Rabkin R,Ryan MP,Duckworth WC

    更新日期：1984-09-01 00:00:00

  • Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs.

    abstract：:Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00401051

    authors： Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

    更新日期：1990-02-01 00:00:00

  • Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis.

    abstract：:Lack of insulin receptors in mice is associated with near-normal intrauterine growth, unlike patients with leprechaunism, in whom growth deficiency is a prominent clinical feature. Genetic crosses of insulin receptor- and insulin-like growth-factor-1 (IGF-1) receptor-deficient mice indicate, however, that insulin rece...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050886

    authors： Cinti S,Eberbach S,Castellucci M,Accili D

    更新日期：1998-02-01 00:00:00

  • N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-012-2685-z

    authors： Treweeke AT,Winterburn TJ,Mackenzie I,Barrett F,Barr C,Rushworth GF,Dransfield I,MacRury SM,Megson IL

    更新日期：2012-11-01 00:00:00

  • Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy.

    abstract：AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-011-2363-6

    authors： Murphy HR,Elleri D,Allen JM,Harris J,Simmons D,Rayman G,Temple RC,Umpleby AM,Dunger DB,Haidar A,Nodale M,Wilinska ME,Hovorka R

    更新日期：2012-02-01 00:00:00

  • The role of coronary artery calcification testing in incident coronary artery disease risk prediction in type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:We sought to assess the role of coronary artery calcification (CAC) and its progression in predicting incident coronary artery disease (CAD) in individuals with type 1 diabetes using data from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. METHODS:The present study examined 292 part...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-018-4764-2

    authors： Guo J,Erqou SA,Miller RG,Edmundowicz D,Orchard TJ,Costacou T

    更新日期：2019-02-01 00:00:00

  • Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.

    abstract：AIMS/HYPOTHESIS:We investigated the association of variants of the transcription factor 7-like 2 (TCF7L2) gene with: (1) incident diabetes in the Finnish Diabetes Prevention Study (DPS, Study I); (2) type 2 diabetes and impaired glucose regulation (i.e. IGT or IFG) in a cross-sectional study (Study II); and (3) insulin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0656-6

    authors： Wang J,Kuusisto J,Vänttinen M,Kuulasmaa T,Lindström J,Tuomilehto J,Uusitupa M,Laakso M

    更新日期：2007-06-01 00:00:00

  • Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery.

    abstract：AIMS/HYPOTHESIS:The intestine is the main site for glucose absorption and it has been suggested that it exhibits insulin resistance. Bariatric surgery has been shown to reverse insulin resistance and type 2 diabetes, but its effects on human intestinal metabolism are unknown. Our aim was to evaluate the effects of insu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3501-3

    authors： Mäkinen J,Hannukainen JC,Karmi A,Immonen HM,Soinio M,Nelimarkka L,Savisto N,Helmiö M,Ovaska J,Salminen P,Iozzo P,Nuutila P

    更新日期：2015-05-01 00:00:00