Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis.

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

journal_title：Diabetologia

authors： Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...

journal_title：Diabetologia

authors： Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

更新日期：2008-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

journal_title：Diabetologia

authors： Choi BC,Shi F

更新日期：2001-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-...

journal_title：Diabetologia

authors： Hird TR,Zomer E,Owen A,Chen L,Ademi Z,Magliano DJ,Liew D

更新日期：2019-07-01 00:00:00

abstract：:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...

journal_title：Diabetologia

authors： Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

更新日期：1987-12-01 00:00:00

abstract：:We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...

journal_title：Diabetologia

authors： Stagner JI,Samols E,Marks V

更新日期：1989-03-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：:Glutathione-insulin transhydrogenase catalyzed the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats....

journal_title：Diabetologia

authors： Taylor CA,Varandani PT

更新日期：1981-11-01 00:00:00

abstract：:Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...

journal_title：Diabetologia

authors： Arrojo E Drigo R,Roy B,MacDonald PE

更新日期：2020-10-01 00:00:00

abstract：:The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...

journal_title：Diabetologia

authors： Nair KS,Halliday D,Garrow JS

更新日期：1984-07-01 00:00:00

abstract：:The microvascular permeability to small and large molecules was studied during good and poor metabolic regulation in ten short duration juvenile diabetics. The following variables were measured; daily urinary albumin and beta2-microglobulin-excretion rates, whole body transcapillary escape rate of albumin (TER), glome...

journal_title：Diabetologia

authors： Parving HH,Noer I,Deckert T,Evrin PE,Nielsen SL,Lyngsoe J,Mogensen CE,Rorth M,Svendsen PA,Trap-Jensen J,Lassen NA

更新日期：1976-05-01 00:00:00

abstract：:Plasma corticosterone concentrations in diabetic (db) mice maintained on two different inbred backgrounds were found to be elevated significantly when compared to normal controls. These data are similar to that reported with the phenotypically similar obese (ob) mouse. These results suggest that the hyperadrenolcortic...

journal_title：Diabetologia

authors： Coleman DL,Burkart DL

更新日期：1977-01-01 00:00:00

abstract：:Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bi...

journal_title：Diabetologia

authors： Frier BM,Faber OK,Binder C,Elliot HL

更新日期：1978-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...

journal_title：Diabetologia

authors： Wang P,Renes J,Bouwman F,Bunschoten A,Mariman E,Keijer J

更新日期：2007-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study aimed to elucidate the mechanism of increased proliferation of alpha cells in recent-onset type 1 diabetes. Pancreatic beta cells express GAD and produce γ-aminobutyric acid (GABA), which inhibits alpha cell secretion of glucagon. We explored the roles of GABA in alpha cell proliferation in c...

journal_title：Diabetologia

authors： Feng AL,Xiang YY,Gui L,Kaltsidis G,Feng Q,Lu WY

更新日期：2017-06-01 00:00:00

abstract：:Plasma insulin and growth hormone levels were measured during morning and afternoon oral glucose tolerance tests performed on 12 young men at three monthly intervals in the Antarctic. No diurnal or seasonal differences in growth hormone levels were found. However there were diurnal and seasonal variations in the blood...

journal_title：Diabetologia

authors： Campbell IT,Jarrett RJ,Rutland P,Stimmler L

更新日期：1975-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had b...

journal_title：Diabetologia

authors： Sellins KS,Gold DP,Bellgrau D

更新日期：1996-01-01 00:00:00

abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...

journal_title：Diabetologia

authors： Fontela T,Garcia Hermida O,Gómez-Acebo J

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Few studies have investigated the relationship between predefined dietary patterns and type 2 diabetes incidence; little is known about the generalisability of these associations. We aimed to assess the association between predefined dietary patterns and type 2 diabetes risk in European populations. ME...

journal_title：Diabetologia

authors： InterAct Consortium.

更新日期：2014-02-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...

journal_title：Diabetologia

authors： Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

更新日期：2019-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

journal_title：Diabetologia

authors： Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

更新日期：2016-11-01 00:00:00

abstract：:Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...

journal_title：Diabetologia

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1984-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) is a risk factor for perinatal complications. In several countries, the criteria for the diagnosis of GDM have been in flux, the American Diabetes Association (ADA) thresholds recommended in 2000 being lower than those of the National Diabetes Data Group (NDDG) that h...

journal_title：Diabetologia

authors： Ferrara A,Weiss NS,Hedderson MM,Quesenberry CP Jr,Selby JV,Ergas IJ,Peng T,Escobar GJ,Pettitt DJ,Sacks DA

更新日期：2007-02-01 00:00:00

abstract：:This study aimed at evaluating the influence of furosemide upon insulin and glucagon responses to arginine in healthy subjects. For this purpose, six normal subjects received two consecutive arginine pulses (3 g), 60 min apart, before and after the administration of furosemide (40 mg, IV). The acute insulin response (...

journal_title：Diabetologia

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1980-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

journal_title：Diabetologia

authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes. METHODS:C57/BL6J mice were placed on an HF diet for 3 months and treated with L803-mts for 20...

journal_title：Diabetologia

authors： Rao R,Hao CM,Redha R,Wasserman DH,McGuinness OP,Breyer MD

更新日期：2007-02-01 00:00:00