The impact of diabetes on productivity in China.

Abstract:

AIMS/HYPOTHESIS:Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. METHODS:Life table modelling was used with simulated follow-up of those with diabetes in the Chinese population of working age (20-49 years in women and 20-59 years in men) until retirement age (50 years for women and 60 years for men). Data regarding the prevalence of diabetes, as well as excess mortality, labour force dropout and productivity loss attributable to diabetes, were taken from published sources. Models were constructed for the cohort with diabetes and repeated for the same cohort assuming that they had no diabetes. The differences in number of deaths, years of life lived and PALYs lived between the two models reflected the impact of diabetes. The WHO standard 3% annual discount rate was applied to years of life and PALYs lived. RESULTS:In 2017, an estimated 56.4 million people of working age in China (7.1%) had diabetes. With simulated follow-up until retirement, those with diabetes were predicted to experience an estimated 4.1 million more deaths, the loss of an additional 22.7 million years of life (3.7%) and the loss of an additional 75.8 million PALYs (15.1%). This was equivalent to an average of 1.3 PALYs lost per person with diabetes. Based on gross domestic product (GDP) per full-time worker in 2017, the loss in PALYs equated to a total of Chinese ¥17.4 trillion (US$2.6 trillion) in lost GDP owing to reduced productivity, with an average of ¥307,925 (US$45,959) lost per person with diabetes. CONCLUSIONS/INTERPRETATION:Our study demonstrates the significant cumulative impact of diabetes on productivity across the working lifetime in the Chinese population, highlighting the potential economic benefits of diabetes prevention in the longer term.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Hird TR,Zomer E,Owen A,Chen L,Ademi Z,Magliano DJ,Liew D

doi

10.1007/s00125-019-4875-4

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

1195-1203

issue

7

eissn

0012-186X

issn

1432-0428

pii

10.1007/s00125-019-4875-4

journal_volume

62

pub_type

杂志文章
  • Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment.

    abstract::The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00428782

    authors: Vestergaard H,Andersen PH,Lund S,Vedel P,Pedersen O

    更新日期:1994-01-01 00:00:00

  • Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to ...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00125-012-2490-8

    authors: Mikus CR,Oberlin DJ,Libla J,Boyle LJ,Thyfault JP

    更新日期:2012-05-01 00:00:00

  • Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.

    abstract:AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3423-5

    authors: Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

    更新日期:2015-02-01 00:00:00

  • Proinsulin C peptide obviates sympathetically mediated suppression of splenic lymphocyte activity in rats.

    abstract:AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051562

    authors: Okamoto S,Kimura K,Kitamura T,Cañas X,Yoshida T,Saito M

    更新日期:2000-12-01 00:00:00

  • HbA(1c) and birthweight in women with pre-conception type 1 and type 2 diabetes: a population-based cohort study.

    abstract:AIMS/HYPOTHESIS:To investigate clinical and sociodemographic predictors of birthweight in singletons born to women with type 1 or type 2 diabetes. METHODS:Normally formed singleton live births and intrapartum stillbirths, born to women with pre-conception diabetes during 1996-2008, were identified from the population-...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2721-z

    authors: Glinianaia SV,Tennant PW,Bilous RW,Rankin J,Bell R

    更新日期:2012-12-01 00:00:00

  • β-Hydroxybutyrate inhibits histone deacetylase 3 to promote claudin-5 generation and attenuate cardiac microvascular hyperpermeability in diabetes.

    abstract:AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05305-2

    authors: Li B,Yu Y,Liu K,Zhang Y,Geng Q,Zhang F,Li Y,Qi J

    更新日期:2021-01-01 00:00:00

  • The response of gastric inhibitory polypeptide (GIP) and insulin to glucose in duodenal ulcer patients.

    abstract::The response of Gastric Inhibitory Polypeptide (GIP) and insulin to a 50 g oral glucose tolerance test (OGTT) and an intravenous glucose infusion (IVGI), which copied the changes in plasma glucose concentrations during the OGTT, were measured in 10 patients with duodenal ulcer and in 10 healthy control subjects. The m...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00429773

    authors: Lauritsen KB,Moody AJ

    更新日期:1978-03-01 00:00:00

  • Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice.

    abstract::Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050896

    authors: Tian J,Chau C,Kaufman DL

    更新日期:1998-02-01 00:00:00

  • Glucose tolerance and other determinants of cardiovascular autonomic function: the Hoorn Study.

    abstract:AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051344

    authors: Gerritsen J,Dekker JM,TenVoorde BJ,Bertelsmann FW,Kostense PJ,Stehouwer CD,Heine RJ,Nijpels G,Heethaar RM,Bouter LM

    更新日期:2000-05-01 00:00:00

  • Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy.

    abstract:AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-001-0769-2

    authors: Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

    更新日期:2002-03-01 00:00:00

  • Reduction of plasma 1,5-anhydroglucitol (1-deoxyglucose) concentration in diabetic patients.

    abstract::The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00279131

    authors: Yamanouchi T,Akanuma H,Nakamura T,Akaoka I,Akanuma Y

    更新日期:1988-01-01 00:00:00

  • Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins.

    abstract::We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00252411

    authors: Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

    更新日期:1984-03-01 00:00:00

  • Restriction fragment length polymorphism (RFLP) of the human insulin receptor gene in Japanese: its possible usefulness as a genetic marker.

    abstract::Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00869268

    authors: Takeda J,Seino Y,Yoshimasa Y,Fukumoto H,Koh G,Kuzuya H,Imura H,Seino S

    更新日期:1986-09-01 00:00:00

  • Advances and prospects in glucose assay technology.

    abstract::The evolution of glucose assay methods has been central to the development of present therapies for diabetes mellitus. However, new blood glucose assay capabilities, such as convenient and truly continuous monitoring, are now needed to foster a new era of close blood glucose control. The principles and present status ...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s001250051418

    authors: Gough DA,Armour JC,Baker DA

    更新日期:1997-07-01 00:00:00

  • Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10). METHODS:We studied 203 men of the same age but with varying degr...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1393-8

    authors: Tripathy D,Eriksson KF,Orho-Melander M,Fredriksson J,Ahlqvist G,Groop L

    更新日期:2004-05-01 00:00:00

  • Engineered cell lines for insulin replacement in diabetes: current status and future prospects.

    abstract::The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale appl...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s001250051398

    authors: Newgard CB,Clark S,BeltrandelRio H,Hohmeier HE,Quaade C,Normington K

    更新日期:1997-07-01 00:00:00

  • Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

    abstract:AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-013-3080-0

    authors: Lorenzo C,Hanley AJ,Haffner SM

    更新日期:2014-01-01 00:00:00

  • Autoantibodies against sympathetic ganglia and evidence of cardiac sympathetic dysinnervation in newly diagnosed and long-term IDDM patients.

    abstract::To investigate the presence of autoantibodies against sympathetic nervous tissue and their correlation with cardiac sympathetic dysinnervation in insulin-dependent diabetes mellitus (IDDM), 20 newly diagnosed (age 26 +/- 6 years) and 48 long-term IDDM patients (age 40 +/- 13 years, duration of diabetes 22 +/- 12 years...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00403917

    authors: Schsnell O,Muhr D,Dresel S,Tatsch K,Ziegler AG,Haslbeck M,Standl E

    更新日期:1996-08-01 00:00:00

  • Blood-based signatures in type 1 diabetes.

    abstract::Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-015-3843-x

    authors: Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

    更新日期:2016-03-01 00:00:00

  • Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-1810-7

    authors: Ahmed N,Babaei-Jadidi R,Howell SK,Beisswenger PJ,Thornalley PJ

    更新日期:2005-08-01 00:00:00

  • Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

    abstract:AIMS/HYPOTHESIS:We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. METHODS:Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 di...

    journal_title:Diabetologia

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00125-011-2108-6

    authors: Talmud PJ,Cooper JA,Gaunt T,Holmes MV,Shah S,Palmen J,Drenos F,Shah T,Kumari M,Kivimaki M,Whittaker J,Lawlor DA,Day IN,Hingorani AD,Casas JP,Humphries SE

    更新日期:2011-07-01 00:00:00

  • Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011.

    abstract:AIMS/HYPOTHESIS:A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubular cells, known as Armanni-Ebstein lesions. While this observation has been consistently reported for many years, the molecular basis of these lesions remains unclear. METHODS:Using biochemi...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2805-9

    authors: Lau X,Zhang Y,Kelly DJ,Stapleton DI

    更新日期:2013-03-01 00:00:00

  • Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I.

    abstract:AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-016-4127-9

    authors: Davis WA,Zilkens RR,Starkstein SE,Davis TM,Bruce DG

    更新日期:2017-01-01 00:00:00

  • Increased energy expenditure in poorly controlled Type 1 (insulin-dependent) diabetic patients.

    abstract::The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00253494

    authors: Nair KS,Halliday D,Garrow JS

    更新日期:1984-07-01 00:00:00

  • Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05332-z

    authors: Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

    更新日期:2020-11-26 00:00:00

  • Ontogenic changes in proglucagon mRNA in BB diabetes prone and normal rats weaned onto a chow diet.

    abstract::Weaning onto chow diets causes the highest incidence of diabetes in the BB rat. Changes in gut development and absorption of nutrients in the diabetes prone rat and the subsequent effect on pancreatic function may play a role in the ultimate development of the disease. BB diabetes prone (dp) and BB normal (n) dams wer...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050762

    authors: Reimer RA,Field CJ,McBurney MI

    更新日期:1997-08-01 00:00:00

  • Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes.

    abstract:AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1619-x

    authors: Koïtka A,Cao Z,Koh P,Watson AM,Sourris KC,Loufrani L,Soro-Paavonen A,Walther T,Woollard KJ,Jandeleit-Dahm KA,Cooper ME,Allen TJ

    更新日期:2010-03-01 00:00:00

  • Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells.

    abstract:AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-1860-x

    authors: Raile K,Klammt J,Laue S,Garten A,Blüher M,Kralisch S,Klöting N,Kiess W

    更新日期:2005-09-01 00:00:00

  • MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

    abstract:AIMS/HYPOTHESIS:Diabetic cardiomyopathy (DCM) is associated with suppressed autophagy and augmented apoptosis in the heart although the interplay between the two remains elusive. The ability of mammalian sterile 20-like kinase 1 to regulate both autophagy and apoptosis prompted us to investigate it as a possible candid...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-016-4070-9

    authors: Zhang M,Zhang L,Hu J,Lin J,Wang T,Duan Y,Man W,Feng J,Sun L,Jia H,Li C,Zhang R,Wang H,Sun D

    更新日期:2016-11-01 00:00:00

  • What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

    abstract::Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other i...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-019-04975-x

    authors: Williams CL,Long AE

    更新日期:2019-11-01 00:00:00