What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

journal_title：Diabetologia

authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

更新日期：2003-08-01 00:00:00

abstract：:Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...

journal_title：Diabetologia

authors： Shimazu T

更新日期：1981-03-01 00:00:00

abstract：:Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters (via the labelled cytochalasin B binding assay). Similarly to what is observed with insulin, increasing worklo...

journal_title：Diabetologia

authors： Zaninetti D,Greco-Perotto R,Jeanrenaud B

更新日期：1988-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy is a major debilitating disease causing most cases of blindness in humans in the Western world. Photocoagulation is the established therapy of proliferative diabetic retinopathy, although the molecular mechanisms of its effects are still not known. Recently angiostatin...

journal_title：Diabetologia

authors： Spranger J,Hammes HP,Preissner KT,Schatz H,Pfeiffer AF

更新日期：2000-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain natriuretic peptide (BNP) is a potent vasorelaxing and natriuretic peptide that is secreted from the heart and has cardioprotective properties. We have previously generated hypotensive transgenic mice (BNP-Tg mice) that overproduce BNP in the liver, which is released into the circulation. Using th...

journal_title：Diabetologia

authors： Makino H,Mukoyama M,Mori K,Suganami T,Kasahara M,Yahata K,Nagae T,Yokoi H,Sawai K,Ogawa Y,Suga S,Yoshimasa Y,Sugawara A,Tanaka I,Nakao K

更新日期：2006-10-01 00:00:00

abstract：:Studies were made on the effect of the enteroinsular axis on amino acid-induced insulin and glucagon secretion during hyperglycaemia in man. The responses of plasma immunoreactive insulin, C-peptide, and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hypergly...

journal_title：Diabetologia

authors： Shimizu I,Hirota M,Ohboshi C,Mizuno A,Shima K

更新日期：1987-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Interleukin-1beta is a putative mediator of pancreatic beta-cell dysfunction and damage in Type I (insulin-dependent) diabetes mellitus. To better understand the molecular mechanisms involved in IL-1beta effects, we carried out a differential display of mRNA by RT-PCR to identify novel cytokine-regulate...

journal_title：Diabetologia

authors： Chen MC,Schuit F,Eizirik DL

更新日期：1999-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test if exogenous FGF21 is sufficient to prevent diabetes and beta cell loss in New Zealand o...

journal_title：Diabetologia

authors： Laeger T,Baumeier C,Wilhelmi I,Würfel J,Kamitz A,Schürmann A

更新日期：2017-11-01 00:00:00

abstract：:Alloxan-induced diabetes in rats significantly impaired the capacity of the erythrocytes to metabolise glucose in vitro to either lactic acid or CO2. Both these metabolic activities were initially insensitive to insulin in normal as well as in diabetic animals; but became responsive when these cells were subjected to ...

journal_title：Diabetologia

authors： Agarwal VR,Rastogi AK,Sagar P

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...

journal_title：Diabetologia

authors： Chowdhury A,Dyachok O,Tengholm A,Sandler S,Bergsten P

更新日期：2013-07-01 00:00:00

abstract：:Five healthy volunteers and 6 diabetics were given a mixed test meal on two occasions--once with and once without 10 g guar flour. Addition of guar caused a 47% decrease in maximum post-prandial GIP levels, a 48% decrease in blood glucose and a 48% decrease in plasma insulin in normal subjects. In diabetics, addition ...

journal_title：Diabetologia

authors： Morgan LM,Goulder TJ,Tsiolakis D,Marks V,Alberti KG

更新日期：1979-08-01 00:00:00

abstract：:Decreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. Dietary supplementation with fish oils has been shown to augment endothelium-dependent relaxations, principally by improving the release of ...

journal_title：Diabetologia

authors： McVeigh GE,Brennan GM,Johnston GD,McDermott BJ,McGrath LT,Henry WR,Andrews JW,Hayes JR

更新日期：1993-01-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

journal_title：Diabetologia

authors： Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

更新日期：1998-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both ...

journal_title：Diabetologia

authors： Delaigle AM,Senou M,Guiot Y,Many MC,Brichard SM

更新日期：2006-06-01 00:00:00

abstract：:The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...

journal_title：Diabetologia

authors： Andersen O,Gliemann J,Gammeltoft S

更新日期：1977-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

journal_title：Diabetologia

authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

更新日期：2021-01-23 00:00:00

abstract：:Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...

journal_title：Diabetologia

authors： Jenkins D,Penny MA,Mijovic CH,Jacobs KH,Fletcher J,Barnett AH

更新日期：1991-08-01 00:00:00

abstract：:The development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24-36 months post-transplantation in 16 Type 1 (insulin-dep...

journal_title：Diabetologia

authors： Osterby R,Nyberg G,Hedman L,Karlberg I,Persson H,Svalander C

更新日期：1991-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...

journal_title：Diabetologia

authors： Ma X,Zhou Z,Chen Y,Wu Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

journal_title：Diabetologia

authors： Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

更新日期：2016-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:In Type II (non-insulin-dependent) diabetes mellitus, amyloid depletes islet mass. We previously found that 81% of male human islet amyloid polypeptide (IAPP) transgenic mice but only 11% of female mice developed islet amyloid, suggesting that either testosterone promotes or ovarian products protect aga...

journal_title：Diabetologia

authors： Kahn SE,Andrikopoulos S,Verchere CB,Wang F,Hull RL,Vidal J

更新日期：2000-10-01 00:00:00

abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

journal_title：Diabetologia

authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

更新日期：1990-04-01 00:00:00

abstract：:Large-scale, centrally-coordinated screening for undiagnosed type 2 diabetes is an attractive option to reduce the mortality and morbidity resulting from inadequately controlled diabetes. However, there is limited research examining the direct consequences of such screening programmes on outcomes such as cardiovascula...

journal_title：Diabetologia

authors： Shaw JE

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to evaluate factors related to the markedly increased risk of dying from diabetic renal disease in Japanese insulin-dependent diabetic patients compared to those in the USA. The study was based on two population-based cohorts consisting of 1374 cases from Japan and 995 cases from Allegheny Co...

journal_title：Diabetologia

authors： Matsushima M,Tajima N,LaPorte RE,Orchard TJ,Tull ES,Gower IF,Kitagawa T

更新日期：1995-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...

journal_title：Diabetologia

authors： Sampson GP,Shahidi AM,Vagenas D,Pritchard N,Edwards K,Russell AW,Malik RA,Efron N

更新日期：2012-04-01 00:00:00

abstract：:It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...

journal_title：Diabetologia

authors： Cavalot F,Russo I,Mattiello L,Anfossi G,Massucco P,Mularoni E,Hahn AW,Trovati M

更新日期：1997-01-01 00:00:00

abstract：:Despite its anabolic effects on protein balance, acute administration of insulin has been reported to have no effect on skeletal muscle or whole body protein synthesis in man. However, insulin also reduces plasma and intramuscular amino acid availability, which may limit protein synthesis. We have therefore measured t...

journal_title：Diabetologia

authors： Bennet WM,Connacher AA,Smith K,Jung RT,Rennie MJ

更新日期：1990-01-01 00:00:00