Central nervous system regulation of liver and adipose tissue metabolism.

abstract：AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...

journal_title：Diabetologia

authors： Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

更新日期：2003-09-01 00:00:00

abstract：:Peritoneal glucose kinetics were evaluated in the anaesthetized rat, to assess whether the peritoneal cavity would be a suitable site for the implantation of membrane-protected islets of Langerhans (bioartificial pancreas) or the glucose sensor of an artificial B cell. Glucose was measured in peritoneal fluid samples ...

journal_title：Diabetologia

authors： Velho G,Froguel P,Reach G

更新日期：1989-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

journal_title：Diabetologia

authors： Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

更新日期：2001-04-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...

journal_title：Diabetologia

authors： Freedman BI,Hsu FC,Langefeld CD,Rich SS,Herrington DM,Carr JJ,Xu J,Bowden DW,Wagenknecht LE

更新日期：2005-12-01 00:00:00

abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...

journal_title：Diabetologia

authors： Madsen KL,Ariano D,Fedorak RN

更新日期：1995-04-01 00:00:00

abstract：AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...

journal_title：Diabetologia

authors： Kriz J,Padjen AL

更新日期：2003-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperinsulinaemia and insulin resistance, as well as low IGF-I, have been implicated in the pathogenesis of cardiovascular disease. Little is known about direct effects of IGF-I and insulin on human coronary artery smooth muscle cells (HCASMCs). Our aim was to characterise the expression and function of...

journal_title：Diabetologia

authors： Chisalita SI,Arnqvist HJ

更新日期：2005-10-01 00:00:00

abstract：:An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin-allergy. No differences were observed between normal perso...

journal_title：Diabetologia

authors： Nakagawa S,Saito N,Nakayama H,Sasaki T,Watanabe T,Aoki S

更新日期：1978-01-14 00:00:00

abstract：AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...

journal_title：Diabetologia

authors： Beyer U,Schäfer D,Thomas A,Aulich H,Haueter U,Reihl B,Ehwald R

更新日期：2001-04-01 00:00:00

abstract：:Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other i...

journal_title：Diabetologia

authors： Williams CL,Long AE

更新日期：2019-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

journal_title：Diabetologia

authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

更新日期：2001-03-01 00:00:00

abstract：:Plasma insulin and growth hormone levels were measured during morning and afternoon oral glucose tolerance tests performed on 12 young men at three monthly intervals in the Antarctic. No diurnal or seasonal differences in growth hormone levels were found. However there were diurnal and seasonal variations in the blood...

journal_title：Diabetologia

authors： Campbell IT,Jarrett RJ,Rutland P,Stimmler L

更新日期：1975-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide b...

journal_title：Diabetologia

authors： Lawrence CL,Proks P,Rodrigo GC,Jones P,Hayabuchi Y,Standen NB,Ashcroft FM

更新日期：2001-08-01 00:00:00

abstract：:In order to characterize pancreatic beta cell function in Geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. The initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) ...

journal_title：Diabetologia

authors： Rabinovitch A,Gutzeit A,Kikuchi M,Cerasi E,Renold AE

更新日期：1975-10-01 00:00:00

abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

journal_title：Diabetologia

authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

更新日期：1990-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. ...

journal_title：Diabetologia

authors： Graiani G,Emanueli C,Desortes E,Van Linthout S,Pinna A,Figueroa CD,Manni L,Madeddu P

更新日期：2004-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...

journal_title：Diabetologia

authors： Hartweg J,Farmer AJ,Perera R,Holman RR,Neil HA

更新日期：2007-08-01 00:00:00

abstract：AIMS:We compared the effects of continuous subcutaneous insulin infusion (CSII) with those of multiple daily insulin (MDI) injections on glycaemic control, risk of hypoglycaemic episodes, insulin requirements and adverse events in type 1 and type 2 diabetes mellitus. METHODS:The electronic databases MEDLINE, EMBASE an...

journal_title：Diabetologia

authors： Jeitler K,Horvath K,Berghold A,Gratzer TW,Neeser K,Pieber TR,Siebenhofer A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...

journal_title：Diabetologia

authors： Finken MJ,Keijzer-Veen MG,Dekker FW,Frölich M,Hille ET,Romijn JA,Wit JM,Dutch POPS-19 Collaborative Study Group.

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or witho...

journal_title：Diabetologia

authors： Cheng Q,Li YC,Boucher BJ,Leung PS

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

journal_title：Diabetologia

authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

更新日期：2001-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...

journal_title：Diabetologia

authors： Westerbacka J,Cornér A,Kannisto K,Kolak M,Makkonen J,Korsheninnikova E,Nyman T,Hamsten A,Fisher RM,Yki-Järvinen H

更新日期：2006-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS:The ABI was measured at baseline in ...

journal_title：Diabetologia

authors： Cardoso CRL,Melo JV,Salles GC,Leite NC,Salles GF

更新日期：2018-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...

journal_title：Diabetologia

authors： Chiu YF,Chuang LM,Kao HY,Ho LT,Ting CT,Hung YJ,Chen YD,Donlon T,Curb JD,Quertermous T,Hsiung CA

更新日期：2007-08-01 00:00:00

abstract：:Studies were made on the effect of the enteroinsular axis on amino acid-induced insulin and glucagon secretion during hyperglycaemia in man. The responses of plasma immunoreactive insulin, C-peptide, and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hypergly...

journal_title：Diabetologia

authors： Shimizu I,Hirota M,Ohboshi C,Mizuno A,Shima K

更新日期：1987-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

journal_title：Diabetologia

authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

更新日期：2005-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. METHODS:We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further inv...

journal_title：Diabetologia

authors： Bork-Jensen J,Scheele C,Christophersen DV,Nilsson E,Friedrichsen M,Fernandez-Twinn DS,Grunnet LG,Litman T,Holmstrøm K,Vind B,Højlund K,Beck-Nielsen H,Wojtaszewski J,Ozanne SE,Pedersen BK,Poulsen P,Vaag A

更新日期：2015-02-01 00:00:00

abstract：:75,375 males called to military service were screened to discover the incidence of hypertrophic pyloric stenosis. 49 men gave a history of previous surgery for this condition and were given a 45 g/m2 oral glucose tolerance test. Fourteen had impaired glucose tolerance. In no case was there a family history of diabetes...

journal_title：Diabetologia

authors： Chimènes H,Gautier D,Bon R,Fromantin M

更新日期：1980-06-01 00:00:00

abstract：:In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...

journal_title：Diabetologia

authors： Lake SP,Chamberlain J,Husken P,Bell PR,James RF

更新日期：1988-06-01 00:00:00