当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

Abstract：

:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain the interstitial concentration of solutes after an equilibration time of approximately 15 min. In normal and in diabetic animals the steady state subcutaneous glucose concentration was almost identical to the circulating glucose level when ranged between 2 and 25 mmol/l. Slow alterations in the circulating glucose profile such as those which appear during an oral glucose tolerance test are closely mirrored by the respective levels in the wick fluid. Fast alterations, however, show deviations. The wick-based glucose levels are well paralleled by the current of Clark type glucose oxidase sensors implanted at the same site. Since, on the basis of in vitro calibrations the sensor outputs have only indicated apparent tissue glucose concentrations of between 70 and 90% of glycaemia, another reference is needed for calibration. Under steady state conditions, the wick method, and on this basis in routine measurements the blood glucose concentration, may be recommended as a reference of implanted sensors which can otherwise not be calibrated in situ.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

doi

10.1007/BF00295878

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

940-5

issue

12

eissn

0012-186X

issn

1432-0428

journal_volume

30

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-05029-y

    authors： Sayers SR,Beavil RL,Fine NHF,Huang GC,Choudhary P,Pacholarz KJ,Barran PE,Butterworth S,Mills CE,Cruickshank JK,Silvestre MP,Poppitt SD,McGill AT,Lavery GG,Hodson DJ,Caton PW

    更新日期：2020-02-01 00:00:00

  • The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. METHODS:We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the ye...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0033-2

    authors： Knerr I,Wolf J,Reinehr T,Stachow R,Grabert M,Schober E,Rascher W,Holl RW,DPV Scientific Initiative of Germany and Austria.

    更新日期：2005-12-01 00:00:00

  • Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?

    abstract：AIMS/HYPOTHESIS:Growth factor imbalance and endothelial progenitor cell dysfunction are well-known elements of the inappropriate response to injury in human and experimental diabetes. We hypothesised that in diabetes the outgrowth of myofibroblast progenitor cells (MFPCs) is also altered and that this relates to aberra...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0172-0

    authors： Nguyen TQ,Chon H,van Nieuwenhoven FA,Braam B,Verhaar MC,Goldschmeding R

    更新日期：2006-05-01 00:00:00

  • Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients.

    abstract：:We investigated the regulation of the mRNA expression of the insulin receptor, insulin receptor substrate-1 (IRS-1) and p85alpha-phosphatidylinositol-3-kinase (PI-3K), three major actors of insulin action, in skeletal muscle from 10 healthy lean volunteers, 13 obese patients with Type II (non-insulin-dependent) diabet...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051163

    authors： Andreelli F,Laville M,Ducluzeau PH,Vega N,Vallier P,Khalfallah Y,Riou JP,Vidal H

    更新日期：1999-03-01 00:00:00

  • Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans.

    abstract：AIMS/HYPOTHESIS:Epithelium-mesenchyme interactions play a major role in pancreas development. Recently, we demonstrated that embryonic pancreatic mesenchyme enhanced progenitor cell proliferation but inhibited endocrine cell differentiation. Here, we investigated the role played by sulphated proteoglycans, which are kn...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0571-2

    authors： Zertal-Zidani S,Bounacer A,Scharfmann R

    更新日期：2007-03-01 00:00:00

  • Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.

    abstract：:Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400353

    authors： Fong Y,Edelstein D,Wang EA,Brownlee M

    更新日期：1993-09-01 00:00:00

  • Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase.

    abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1364-1

    authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

    更新日期：2009-07-01 00:00:00

  • A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.

    abstract：AIMS/HYPOTHESIS:Patients with glucokinase mutations are characterised by mild, persistent fasting hyperglycaemia, a small increment in glucose in response to an oral load and a dominant family history. These patients frequently present with gestational diabetes and often require insulin treatment during pregnancy. We a...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050038

    authors： Ellard S,Beards F,Allen LI,Shepherd M,Ballantyne E,Harvey R,Hattersley AT

    更新日期：2000-02-01 00:00:00

  • Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry.

    abstract：AIMS/HYPOTHESIS:Monogenic diabetes (MD) might be misdiagnosed as type 1 diabetes. The prevalence of MD among children with apparent type 1 diabetes has not been established. Our aim was to estimate the prevalence of common forms of MD in childhood diabetes. METHODS:We investigated 2,756 children aged 0-14 years with n...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-013-2916-y

    authors： Irgens HU,Molnes J,Johansson BB,Ringdal M,Skrivarhaug T,Undlien DE,Søvik O,Joner G,Molven A,Njølstad PR

    更新日期：2013-07-01 00:00:00

  • Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.

    abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-015-3704-7

    authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

    更新日期：2015-10-01 00:00:00

  • Tropical pancreatic diabetes in South India: heterogeneity in clinical and biochemical profile.

    abstract：:Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282238

    authors： Mohan V,Mohan R,Susheela L,Snehalatha C,Bharani G,Mahajan VK,Ramachandran A,Viswanathan M,Kohner EM

    更新日期：1985-04-01 00:00:00

  • Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice.

    abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0065-7

    authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

    更新日期：2006-01-01 00:00:00

  • The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet.

    abstract：:We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265095

    authors： Stagner JI,Samols E,Marks V

    更新日期：1989-03-01 00:00:00

  • A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the effects of a secondary renal insult, due to chronic infusion of AGEs on renal function, and on early pathological markers in rats with a developmental nephron deficit. METHODS:Female Wistar-Kyoto rats were fed a low-protein diet (LPD; 8.7% casein) or a norma...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0175-x

    authors： Zimanyi MA,Denton KM,Forbes JM,Thallas-Bonke V,Thomas MC,Poon F,Black MJ

    更新日期：2006-04-01 00:00:00

  • Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0331-3

    authors： Melander A,Folino-Gallo P,Walley T,Schwabe U,Groop PH,Klaukka T,Vallano A,Laporte JR,Gallego MR,Schiappa M,Røder M,Kampmann JP,de Swaef A,Aberg M,Månsson NO,Lindblad U

    更新日期：2006-09-01 00:00:00

  • Pancreatic secretion in man with subclinical vitamin D deficiency.

    abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02427278

    authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

    更新日期：1986-01-01 00:00:00

  • Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.

    abstract：UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051578

    authors： Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

    更新日期：2001-01-01 00:00:00

  • Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects.

    abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00422367

    authors： George E,Harris N,Bedford C,Macdonald IA,Hardisty CA,Heller SR

    更新日期：1995-10-01 00:00:00

  • Renal hypertrophy in experimental diabetes: relation to severity of diabetes.

    abstract：:Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00745142

    authors： Seyer-Hansen K

    更新日期：1977-04-01 00:00:00

  • A study of capillary pericyte viability on extracellular matrix produced by endothelial cells in high glucose.

    abstract：AIMS/HYPOTHESIS:Thickening of the basement membrane and selective loss of pericytes occur early in diabetic retinopathy. As we showed previously that pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations, we aimed to verify if altered adhesion could influence ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1043-6

    authors： Beltramo E,Buttiglieri S,Pomero F,Allione A,D'Alù F,Ponte E,Porta M

    更新日期：2003-03-01 00:00:00

  • Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.

    abstract：AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0942-y

    authors： Ellard S,Bellanné-Chantelot C,Hattersley AT,European Molecular Genetics Quality Network (EMQN) MODY group.

    更新日期：2008-04-01 00:00:00

  • Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering type 1 (insulin-dependent) diabetic children.

    abstract：:Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00285294

    authors： Drummond K,Levy-Marchal C,Laborde K,Kindermans C,Wright C,Dechaux M,Czernichow P

    更新日期：1989-04-01 00:00:00

  • The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00125-003-1175-8

    authors： Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

    更新日期：2003-09-01 00:00:00

  • Identification and analysis of murine pancreatic islet enhancers.

    abstract：AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2797-5

    authors： Tennant BR,Robertson AG,Kramer M,Li L,Zhang X,Beach M,Thiessen N,Chiu R,Mungall K,Whiting CJ,Sabatini PV,Kim A,Gottardo R,Marra MA,Lynn FC,Jones SJ,Hoodless PA,Hoffman BG

    更新日期：2013-03-01 00:00:00

  • Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.

    abstract：AIMS/HYPOTHESIS:Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional s...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-018-4612-4

    authors： Perez-Alcantara M,Honoré C,Wesolowska-Andersen A,Gloyn AL,McCarthy MI,Hansson M,Beer NL,van de Bunt M

    更新日期：2018-07-01 00:00:00

  • A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. METHODS:This was an observational study of 107 consecutive pregnant women with...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2087-7

    authors： Ringholm L,Pedersen-Bjergaard U,Thorsteinsson B,Boomsma F,Damm P,Mathiesen ER

    更新日期：2011-07-01 00:00:00

  • Risk factors for renal failure: the WHO Mulinational Study of Vascular Disease in Diabetes.

    abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/pl00002939

    authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

    更新日期：2001-09-01 00:00:00

  • Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.

    abstract：AIMS/HYPOTHESIS:Dysfunction of lipid metabolism in white adipose tissue can substantially interfere with health and quality of life, for example in obesity and associated metabolic diseases. Therefore, it is important to characterise pathways that regulate lipid handling in adipocytes and determine how they affect meta...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4152-8

    authors： Kaltenecker D,Mueller KM,Benedikt P,Feiler U,Themanns M,Schlederer M,Kenner L,Schweiger M,Haemmerle G,Moriggl R

    更新日期：2017-02-01 00:00:00

  • Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids.

    abstract：:The aim of the present study was to measure whole body glucose uptake (M) and oxidation rate by euglycaemic hyperinsulinaemic clamp and indirect calorimetry in 7 morbidly obese subjects (BMI > 40 kg/m2) at three time points: before bilio-pancreatic diversion (BPD) surgery (Ob); 3 months after surgery POI; and after re...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050721

    authors： Mingrone G,DeGaetano A,Greco AV,Capristo E,Benedetti G,Castagneto M,Gasbarrini G

    更新日期：1997-05-01 00:00:00

  • The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells.

    abstract：:Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051054

    authors： Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

    更新日期：1998-10-01 00:00:00