Tropical pancreatic diabetes in South India: heterogeneity in clinical and biochemical profile.

Abstract:

:Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tropical pancreatic diabetes had clinical evidence of malnutrition. There was no history of cassava ingestion. Mean serum cholesterol concentration was significantly lower in the tropical pancreatic diabetic patients (p less than 0.01) in comparison with the Type 2 diabetic patients or non-diabetic subjects, due to a significantly decreased concentration of LDL cholesterol (p less than 0.01) and VLDL cholesterol (p less than 0.05). Basal and post-glucose stimulated concentrations of serum C-peptide were highest in those pancreatic diabetic patients (n = 11) who responded to oral hypoglycaemic drugs, intermediate in the majority (n = 17), who were insulin dependent and ketosis resistant and negligible in a small sub-group (n = 5) who were ketosis prone. The occurrence of microangiopathy in pancreatic diabetic patients was common and similar to that in Type 2 diabetic patients. Thus, tropical pancreatic diabetes in South India appears to be heterogeneous with respect to level of nutrition, severity of glucose intolerance, B-cell function, response to therapy and the occurrence of microvascular complications.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Mohan V,Mohan R,Susheela L,Snehalatha C,Bharani G,Mahajan VK,Ramachandran A,Viswanathan M,Kohner EM

doi

10.1007/BF00282238

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

229-32

issue

4

eissn

0012-186X

issn

1432-0428

journal_volume

28

pub_type

杂志文章
  • Influence of affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme linked immunosorbent assay. Demonstration using monoclonal antibodies raised against rDNA human proinsulin.

    abstract::Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but none did with labelled C-peptide indicating that the involved epitop...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00403281

    authors: Sodoyez JC,Koch M,Lemaire I,Sodoyez-Goffaux F,Rapaille A,François-Gérard C,Sondag D

    更新日期:1991-07-01 00:00:00

  • Incidence and prevalence of type 2 diabetes by occupation: results from all Swedish employees.

    abstract:AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-04997-5

    authors: Carlsson S,Andersson T,Talbäck M,Feychting M

    更新日期:2020-01-01 00:00:00

  • Diabetes as a risk factor for stroke. A population perspective.

    abstract::Stroke incidence, case fatality and mortality in diabetic patients were compared to non-diabetic subjects in a 35-74-year-old population in northern Sweden (target population 241,000). During an 8-year period, 1,544 stroke events in diabetic patients and 4,826 events in non-diabetic subjects were recorded. The crude i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00402176

    authors: Stegmayr B,Asplund K

    更新日期:1995-09-01 00:00:00

  • Abnormal increases in urinary albumin excretion during pregnancy in IDDM women with pre-existing microalbuminuria.

    abstract::We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00400946

    authors: Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby U

    更新日期:1994-09-01 00:00:00

  • Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.

    abstract::It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400672

    authors: Isami S,Kishikawa H,Araki E,Uehara M,Kaneko K,Shirotani T,Todaka M,Ura S,Motoyoshi S,Matsumoto K,Miyamura N,Shichiri M

    更新日期:1996-04-01 00:00:00

  • Risk stratification systems for diabetic foot ulcers: a systematic review.

    abstract:AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-010-2030-3

    authors: Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

    更新日期:2011-05-01 00:00:00

  • IgG4-subclass of glutamic acid decarboxylase antibody is more frequent in latent autoimmune diabetes in adults than in type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1558-5

    authors: Hillman M,Törn C,Thorgeirsson H,Landin-Olsson M

    更新日期:2004-11-01 00:00:00

  • Hyperproinsulinaemia in patients with myotonic dystrophy.

    abstract::Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00401372

    authors: Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

    更新日期:1992-12-01 00:00:00

  • Pentamidine, a new diabetogenic drug in laboratory rodents.

    abstract::The antiprotozoal drug, pentamidine, has been reported to induce hypoglycaemia associated with inappropriately high plasma insulin concentrations, followed by insulin-dependent diabetes mellitus. It has been suggested that this drug can be toxic to the islet B cell, inducing early cytolytic release of insulin leading ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00282521

    authors: Saï P,Boillot D,Boitard C,Debray-Sachs M,Reach G,Assan R

    更新日期:1983-11-01 00:00:00

  • Tubular lesions in streptozotocin-diabetic rats.

    abstract::Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00253498

    authors: Rasch R

    更新日期:1984-07-01 00:00:00

  • An epidemiological study of childhood diabetes affecting two or more siblings.

    abstract::The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00280517

    authors: Gamble DR

    更新日期:1980-10-01 00:00:00

  • Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes.

    abstract:AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1619-x

    authors: Koïtka A,Cao Z,Koh P,Watson AM,Sourris KC,Loufrani L,Soro-Paavonen A,Walther T,Woollard KJ,Jandeleit-Dahm KA,Cooper ME,Allen TJ

    更新日期:2010-03-01 00:00:00

  • Immunoisolation of pancreatic B cells by microencapsulation. An in vitro study.

    abstract::The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00265027

    authors: Darquy S,Reach G

    更新日期:1985-10-01 00:00:00

  • Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10). METHODS:We studied 203 men of the same age but with varying degr...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1393-8

    authors: Tripathy D,Eriksson KF,Orho-Melander M,Fredriksson J,Ahlqvist G,Groop L

    更新日期:2004-05-01 00:00:00

  • Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...

    journal_title:Diabetologia

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00125-007-0783-0

    authors: Eriksen L,Dahl-Petersen I,Haugaard SB,Dela F

    更新日期:2007-11-01 00:00:00

  • A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

    abstract:AIMS/HYPOTHESIS:The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical....

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-1191-9

    authors: Fex M,Haemmerle G,Wierup N,Dekker-Nitert M,Rehn M,Ristow M,Zechner R,Sundler F,Holm C,Eliasson L,Mulder H

    更新日期:2009-02-01 00:00:00

  • Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals.

    abstract:AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. METHODS:In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing allele...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3308-7

    authors: Zhu J,Zong G,Lu L,Gan W,Ji L,Hu R,Ye X,Sun L,Loos RJ,Li H,Lin X

    更新日期:2014-09-01 00:00:00

  • Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1308-9

    authors: Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

    更新日期:2009-05-01 00:00:00

  • Preventive effects of cyclosporin on diabetes in NOD mice.

    abstract::Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00454884

    authors: Mori Y,Suko M,Okudaira H,Matsuba I,Tsuruoka A,Sasaki A,Yokoyama H,Tanase T,Shida T,Nishimura M

    更新日期:1986-04-01 00:00:00

  • Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-006-0331-3

    authors: Melander A,Folino-Gallo P,Walley T,Schwabe U,Groop PH,Klaukka T,Vallano A,Laporte JR,Gallego MR,Schiappa M,Røder M,Kampmann JP,de Swaef A,Aberg M,Månsson NO,Lindblad U

    更新日期:2006-09-01 00:00:00

  • Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population.

    abstract:AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-009-1335-6

    authors: Hu C,Wang C,Zhang R,Ma X,Wang J,Lu J,Qin W,Bao Y,Xiang K,Jia W

    更新日期:2009-07-01 00:00:00

  • Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension.

    abstract::Recent studies have suggested an association between a deletion (D) variant of the angiotensin-converting-enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension,...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050662

    authors: Ringel J,Beige J,Kunz R,Distler A,Sharma AM

    更新日期:1997-02-01 00:00:00

  • A method for the purification of single A, B and D cells and for the isolation of coupled cells from isolated rat islets.

    abstract::A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00257436

    authors: Pipeleers DG,Pipeleers-Marichal MA

    更新日期:1981-06-01 00:00:00

  • Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets.

    abstract:AIMS/HYPOTHESIS:In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also re...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-002-0833-6

    authors: Boujendar S,Reusens B,Merezak S,Ahn MT,Arany E,Hill D,Remacle C

    更新日期:2002-06-01 00:00:00

  • Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.

    abstract::Recently, we described a leprechaun patient with a genetically transmitted severe insulin resistance due to the absence of functional insulin receptors as inferred from the loss of insulin binding to the patients' fibroblasts and the impaired autophosphorylation of the beta-chain of the receptor. This patient was homo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00274534

    authors: Lekanne Deprez RH,Potter van Loon BJ,van der Zon GC,Möller W,Lindhout D,Klinkhamer MP,Krans HM,Maassen JA

    更新日期:1989-10-01 00:00:00

  • Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans.

    abstract:AIMS/HYPOTHESIS:We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. METHODS:Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean ± SEM BMI 33.3 ± 1.4 kg/m(2)), individuals with type 2 ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-011-2419-7

    authors: Bergman BC,Hunerdosse DM,Kerege A,Playdon MC,Perreault L

    更新日期:2012-04-01 00:00:00

  • A vascular mechanism for high-sodium-induced insulin resistance in rats.

    abstract:AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-014-3373-y

    authors: Premilovac D,Richards SM,Rattigan S,Keske MA

    更新日期:2014-12-01 00:00:00

  • Pioglitazone-induced increase of insulin sensitivity in the muscles of the obese Zucker fa/fa rat cannot be explained by local adipocyte differentiation.

    abstract::Thiazolidinediones are potent antidiabetic compounds, which act by enhancing peripheral insulin sensitivity. They are also activators of the peroxisome proliferator activated receptor gamma in adipose tissue. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat and hence the capacity of...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051014

    authors: Hallakou S,Foufelle F,Doaré L,Kergoat M,Ferré P

    更新日期:1998-08-01 00:00:00

  • Treatment of diabetes mellitus.

    abstract::New treatment strategies for subjects with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus are being developed. Pilot studies utilising insulin itself have been reported to prevent Type 1 diabetes in subjects likely, by immunogenetic and physiologic criteria, to develop clinically overt...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/BF00586274

    authors: Robertson RP,Klein DJ

    更新日期:1992-12-01 00:00:00

  • Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme.

    abstract:UNLABELLED:AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiov...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s001250051229

    authors: Eriksson J,Lindström J,Valle T,Aunola S,Hämäläinen H,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Laakso M,Lauhkonen M,Lehto P,Lehtonen A,Louheranta A,Mannelin M,Martikkala V,Rastas M,Sundvall J,Turpeinen A,Viljanen T,Uus

    更新日期:1999-07-01 00:00:00