Abstract：
:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeostasis and on insulin sensitivity using the euglycaemic hyperinsulinaemic clamp. The amylin used opposed insulin-mediated glucose disposal in rat soleus muscle at concentrations of 10 nmol/l. Seven subjects were studied on two occasions and infused with either amylin or placebo for 6 h, initially when postabsorptive and then during a euglycaemic hyperinsulinaemic clamp. Mean plasma amylin concentrations during the first 3 h were 2006 +/- 327 pmol/l during amylin infusion and 20 +/- 9 pmol/l during the control infusion. Amylin infusion had no effect on postabsorptive plasma concentrations of insulin (control: 32 +/- 16 vs amylin: 25 +/- 8 pmol/l) or glucose (5.1 +/- 0.1 vs 5.3 +/- 0.1 mmol/l). During the clamp, amylin concentrations were 1636 +/- 422 pmol/l when it was infused and 24 +/- 6 during control infusions. Plasma glucose and insulin concentrations were well matched during the control and amylin infusions (glucose: 4.7 +/- 0.1 vs 4.8 +/- 0.1 mmol/l; insulin: 198 +/- 37 vs 195 +/- 22 pmol/l). Exogenous glucose infusion rates were a mean of 13% lower than control values during the amylin infusion but were not statistically different (p = 0.17).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Wilding JP,Khandan-Nia N,Bennet WM,Gilbey SG,Beacham J,Ghatei MA,Bloom SRdoi
10.1007/s001250050088subject
Has Abstractpub_date
1994-02-01 00:00:00pages
166-9issue
2eissn
0012-186Xissn
1432-0428journal_volume
37pub_type
临床试验,杂志文章相关文献
DIABETOLOGIA文献大全abstract：AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-003-1149-x
更新日期：2003-08-01 00:00:00
abstract：:Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400276
更新日期：1991-08-01 00:00:00
abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/BF00403384
更新日期：1994-06-01 00:00:00
abstract：:Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF01223621
更新日期：1979-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/s00125-011-2363-6
更新日期：2012-02-01 00:00:00
abstract：:Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00869268
更新日期：1986-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Acute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair gluco...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2662-6
更新日期：2012-11-01 00:00:00
abstract：:Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in order to map out the sequence of changes that accompany chronic hyperglycaemia. In vitro pancreas perfusions were ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400800
更新日期：1993-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to assess and compare risks of having large- or small-for gestational age (LGA and SGA, respectively) infants born to women with gestational diabetes mellitus (GDM) from ten racial/ethnic groups. METHODS:LGA and SGA were defined as birthweight >90th and <10th percentile, respe...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3420-8
更新日期：2015-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title：Diabetologia
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00125-012-2685-z
更新日期：2012-11-01 00:00:00
abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00274225
更新日期：1987-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Acute insulinaemia activates the sympathetic drive in a nonuniform manner. The extent and nature of such activation in type 2 diabetic patients who do not have neuropathy have not yet been addressed despite evidence relating sympathetic activation to cardiovascular risk. We planned to determine the magn...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1601-6
更新日期：2005-01-01 00:00:00
abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00408356
更新日期：1991-11-01 00:00:00
abstract：:We investigated the regulation of the mRNA expression of the insulin receptor, insulin receptor substrate-1 (IRS-1) and p85alpha-phosphatidylinositol-3-kinase (PI-3K), three major actors of insulin action, in skeletal muscle from 10 healthy lean volunteers, 13 obese patients with Type II (non-insulin-dependent) diabet...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051163
更新日期：1999-03-01 00:00:00
abstract：:Abnormal vascular endothelium function may contribute to the reduced nerve perfusion implicated in the aetiology of neuropathy in diabetes mellitus. The aim was to test the hypothesis that a powerful vasoconstrictor, endothelin-1, could be involved in nerve dysfunction in streptozotocin-diabetic rats. After 6 weeks of...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00399794
更新日期：1994-12-01 00:00:00
abstract：:The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i.v. glucose in normal subjects but not in chemica...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00429842
更新日期：1975-04-01 00:00:00
abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-011-2348-5
更新日期：2012-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4190-2
更新日期：2017-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied ...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究
doi：10.1007/s00125-011-2347-6
更新日期：2012-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-05029-y
更新日期：2020-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-009-1510-9
更新日期：2009-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Fenofibrate is a drug used to treat hyperlipidaemia that works by inhibiting hepatic triacylglycerol synthesis. Sterol regulatory element binding protein-1c (SREBP-1c) is a major regulator of the expression of genes involved in hepatic triacylglycerol synthesis. In addition, endoplasmic reticulum (ER)-b...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2771-2
更新日期：2013-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051464
更新日期：2000-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-009-1308-9
更新日期：2009-05-01 00:00:00
abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00404800
更新日期：1990-04-01 00:00:00
abstract：:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DO...
journal_title：Diabetologia
pub_type： 评论,杂志文章
doi：10.1007/s00125-015-3539-2
更新日期：2015-05-01 00:00:00
abstract：:Plasma insulin, intact proinsulin and 32-33 split proinsulin measured by specific immunoradiometric assays and insulin and C-peptide measured by radioimmunoassay were measured during a constant infusion of glucose test in ten diet-treated subjects with a history of Type 2 (non-insulin-dependent) diabetes (termed diabe...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF02342446
更新日期：1992-05-01 00:00:00
abstract：:It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050644
更新日期：1997-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-015-3665-x
更新日期：2015-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-006-0354-9
更新日期：2006-09-01 00:00:00
