Blood flow in the diabetic neuropathic foot.

abstract：AIMS/HYPOTHESIS:We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. METHODS:The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-...

journal_title：Diabetologia

authors： Carr AL,Sluiman AJ,Grecian SM,Forster R,McLachlan S,Strachan MWJ,Price JF

更新日期：2021-02-01 00:00:00

abstract：:QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...

journal_title：Diabetologia

authors： Ewing DJ,Boland O,Neilson JM,Cho CG,Clarke BF

更新日期：1991-03-01 00:00:00

abstract：:Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...

journal_title：Diabetologia

authors： Koffler M,Imamura T,Santeusanio F,Helderman JH

更新日期：1988-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is...

journal_title：Diabetologia

authors： Ittner AA,Bertz J,Chan TY,van Eersel J,Polly P,Ittner LM

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mild cognitive dysfunction is not uncommon in adults with Type 1 diabetes, but its pathogenesis remains unclear. Previous cross-sectional studies had suggested that microangiopathy might affect brain integrity and lead to "central neuropathy." To assess the relationship between changes in cognitive perf...

journal_title：Diabetologia

authors： Ryan CM,Geckle MO,Orchard TJ

更新日期：2003-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

journal_title：Diabetologia

authors： Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

journal_title：Diabetologia

authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

更新日期：2008-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

journal_title：Diabetologia

authors： Golicki DT,Golicka D,Groele L,Pankowska E

更新日期：2008-02-01 00:00:00

abstract：:The present study examined the acute effects of co-ingestion of fat (37.5 g) on the post-prandial metabolic responses to 75 g of carbohydrate which was either slowly absorbed (lentils) or rapidly absorbed (potatoes). Co-ingestion of fat resulted in a significant flattening of the post-prandial glucose curves, the effe...

journal_title：Diabetologia

authors： Collier G,McLean A,O'Dea K

更新日期：1984-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

journal_title：Diabetologia

authors： Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

更新日期：2001-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state. In this study, we investigated the effect of troglitazone, a ligand of the nuclear receptor peroxisom...

journal_title：Diabetologia

authors： Gottschling-Zeller H,Röhrig K,Hauner H

更新日期：2000-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Al...

journal_title：Diabetologia

authors： Franks PW,Jablonski KA,Delahanty L,Hanson RL,Kahn SE,Altshuler D,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.

更新日期：2007-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...

journal_title：Diabetologia

authors： Kamimoto Y,Sugiyama T,Kihira T,Zhang L,Murabayashi N,Umekawa T,Nagao K,Ma N,Toyoda N,Yodoi J,Sagawa N

更新日期：2010-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

journal_title：Diabetologia

authors： Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

更新日期：2020-06-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00

abstract：:The influence of sex on pancreatic islet B cell susceptibility to streptozotocin was studied in mice given multiple low doses of streptozotocin. Male C3 D2 F1 mice developed a steadily increasing blood glucose level after a lag period of about 3 weeks, in contrast to females who were resistant. Spleen cells from strep...

journal_title：Diabetologia

authors： Kromann H,Christy M,Lernmark A,Nedergaard M,Nerup J

更新日期：1982-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...

journal_title：Diabetologia

authors： Dawed AY,Ali A,Zhou K,Pearson ER,Franks PW

更新日期：2017-11-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic ...

journal_title：Diabetologia

authors： Chen J,Sun M,Adeyemo A,Pirie F,Carstensen T,Pomilla C,Doumatey AP,Chen G,Young EH,Sandhu M,Morris AP,Barroso I,McCarthy MI,Mahajan A,Wheeler E,Rotimi CN,Motala AA

更新日期：2019-07-01 00:00:00

abstract：:The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...

journal_title：Diabetologia

authors： Parving HH,Kastrup H,Smidt UM,Andersen AR,Feldt-Rasmussen B,Christiansen JS

更新日期：1984-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...

journal_title：Diabetologia

authors： Zertal-Zidani S,Busiah K,Edelman A,Polak M,Scharfmann R

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...

journal_title：Diabetologia

authors： Ahrén B,Larsson H

更新日期：2001-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：:The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i.v. glucose in normal subjects but not in chemica...

journal_title：Diabetologia

authors： Pontiroli AE,Viberti GC,Tognetti A,Pozza G

更新日期：1975-04-01 00:00:00

abstract：:Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary protein-energy malnutrition in young rats causes a persisting impairment...

journal_title：Diabetologia

authors： Swenne I,Borg LA,Crace CJ,Schnell Landström A

更新日期：1992-10-01 00:00:00

abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...

journal_title：Diabetologia

authors： Rabkin R,Ryan MP,Duckworth WC

更新日期：1984-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. METHODS:Male Holtzman rats of 6 to 8 weeks of age and weighing 170+/-30 g were randomly divided into four groups: control ( n=13), untreated ...

journal_title：Diabetologia

authors： Bosco AA,Lerario AC,Santos RF,Wajchenberg BL

更新日期：2003-12-01 00:00:00

abstract：:Hybridomas producing proinsulin antibodies were cloned by limiting dilution of cell cultures obtained by fusion of splenocytes of immunized mice with immortal myeloma cells. Some proinsulin monoclonal antibodies crossreacted with labelled insulin but none did with labelled C-peptide indicating that the involved epitop...

journal_title：Diabetologia

authors： Sodoyez JC,Koch M,Lemaire I,Sodoyez-Goffaux F,Rapaille A,François-Gérard C,Sondag D

更新日期：1991-07-01 00:00:00