Abstract:
:Type 1 diabetes is an immune-mediated disease leading to almost total beta cell destruction and permanent exogenous insulin dependency. The appearance of clinical symptoms is preceded by an asymptomatic preclinical period, the duration of which is highly individual. The emergence of diabetes-associated autoantibodies into the peripheral circulation is the first detectable sign of beta cell autoimmunity. If type 1 diabetes is diagnosed in childhood the preclinical period lasts for an average of 2.5-3 years, but clinical symptoms may in some cases appear within a few months or be delayed for more than 20 years. In this issue of Diabetologia, Bonifacio and colleagues (doi: 10.1007/s00125-016-4144-8 ) suggest that asymptomatic beta cell autoimmunity should be considered as a pathological and diagnostic entity. Although such a strategy may have some positive consequences, it might also have serious drawbacks. To label an asymptomatic child that may have 10-20 years of a healthy life ahead of him/her as a patient will most likely affect both the life of the family and the child. Therefore, we think that one should not adapt the new diagnosis before the psychological consequences of such a strategy have been assessed. Instead, since metabolic abnormalities precede the appearance of clinical symptoms of type 1 diabetes, analysis of a combination of immunological and metabolic markers will provide better insight into the likelihood of progression to clinical disease, with a shorter 'sickness' period.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Knip M,Selvenius J,Siljander H,Veijola Rdoi
10.1007/s00125-016-4147-5subject
Has Abstractpub_date
2017-01-01 00:00:00pages
39-42issue
1eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-016-4147-5journal_volume
60pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:This study compared the incidence rate of type 1 diabetes in children diagnosed with enterovirus (EV) infections with that in age- and sex-matched children without EV infection in a population-based cohort. In addition, we examined whether the direction or magnitude of the association between EV infecti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3400-z
更新日期:2015-01-01 00:00:00
abstract:AIM/HYPOTHESIS:The aim of this study was to investigate the association between processed and other meat intake and incidence of Type 2 diabetes in a large cohort of women. METHODS:Incident cases of Type 2 diabetes were identified during 8 years of follow-up in a prospective cohort study of 91246 U.S. women aged 26 to...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-003-1220-7
更新日期:2003-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05108-5
更新日期:2020-05-01 00:00:00
abstract::The effect of the alpha-glucosidase inhibitor acarbose on postprandial hyperglycaemia was explored in the spontaneously diabetic BB/W-rat. Acarbose-treatment (5 mg.kg body weight-1.day-1) of diabetic BB/W-rats maintained on small doses of insulin, was associated with a 40% reduction in the 24-h glucose area compared t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401199
更新日期:1992-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3375-9
更新日期:2014-12-01 00:00:00
abstract::The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400254
更新日期:1992-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3665-x
更新日期:2015-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0556-1
更新日期:2007-03-01 00:00:00
abstract::A recent investigation of families containing two and three consecutive generations affected with Type I (insulin dependent) diabetes mellitus has led to speculation that there is a second susceptibility gene, not linked to the major histocompatibility complex. These families differ in important respects from families...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00252759
更新日期:1981-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1914-0
更新日期:2005-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Few studies have investigated the relationship between predefined dietary patterns and type 2 diabetes incidence; little is known about the generalisability of these associations. We aimed to assess the association between predefined dietary patterns and type 2 diabetes risk in European populations. ME...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-013-3092-9
更新日期:2014-02-01 00:00:00
abstract::Hepatic microsomal glucose-6-phosphatase activity levels and the hepatic output of glucose are increased in diabetes. We have used protein chemistry and immunological techniques to determine the mechanism by which the activity levels of the glucose-6-phosphatase system are increased in streptozotocin-induced diabetic ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00291077
更新日期:1985-11-01 00:00:00
abstract::C-peptide was determined in 24-h urine collections and in fasting plasma of 27 Type 1 (insulin-dependent) diabetic children (duration of disease 0-6 years) and in 11 matched normal children. Grouping the patients according to duration of disease from onset to 6 years, it was found that in the first year of disease the...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00297387
更新日期:1983-02-01 00:00:00
abstract::Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401051
更新日期:1990-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels with cardiovascular events in patients with type 2 diabetes. METHODS:Plasma FGF21 levels were meas...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-014-3458-7
更新日期:2015-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3807-1
更新日期:2016-02-01 00:00:00
abstract::A follow-up study was carried out to determine whether reduced fetal growth is associated with the development of impaired glucose tolerance in men and women aged 50 years. Standard oral glucose tolerance tests were carried out on 140 men and 126 women born in Preston (Lancashire, UK) between 1935 and 1943, whose size...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399954
更新日期:1993-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4512-z
更新日期:2018-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The effects of successful pancreas transplant alone (PTA) on chronic complications of diabetes, in particular diabetic retinopathy, remain disputed. We prospectively studied the course of diabetic retinopathy in PTA recipients and in non-transplanted (non-PTA) type 1 diabetic patients. METHODS:The PTA ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0463-5
更新日期:2006-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the effects of oxygen consumption-matched short-term interval walking training (IWT) vs continuous walking training (CWT) on glycaemic control, including glycaemic variability, in individuals with type 2 diabetes. We also assessed whether any training-induced improv...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-016-4170-6
更新日期:2017-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-010-1883-9
更新日期:2011-02-01 00:00:00
abstract::Significant progress has been made in recent years in the characterisation of the signal pathways of beta cell dysfunction and death in the pathogenesis of type 2 diabetes. Glucolipotoxicity acts as an exogenous factor whereas oxidative stress and endoplasmic reticulum stress may result from the processes of signal re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1839-0
更新日期:2010-10-01 00:00:00
abstract::Is the course leading to diabetic end-stage renal disease similar for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus? We identified all diabetic end-stage renal disease patients starting renal replacement therapy from 1989 to 1991 in two urban counties in Texas. Three ethnic/racial gro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02374504
更新日期:1993-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes. METHODS:Pancreatic samples and/or isolated islets from non...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0816-8
更新日期:2007-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Currently, three categories of cardiovascular autonomic nervous function measures are used: classic Ewing-test measures, measures of heart-rate variability (HRV), and measures of baroreflex sensitivity (BRS). Little is known about the agreement between these measures, and reference and reproducibility v...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-003-1032-9
更新日期:2003-03-01 00:00:00
abstract::Analysis of the plasma from a totally pancreatectomized patient, with antiserum 30 K, has demonstrated basal glucagon immunoreactivity (GIR) levels in the normal range (80-110 pg/ml). Neither i. v. arginine nor oral glucose affected these GIR values, thus indicating the absence of functioning pancreatic or gastrointes...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01220639
更新日期:1976-12-01 00:00:00
abstract::Thiazolidinediones are potent antidiabetic compounds, which act by enhancing peripheral insulin sensitivity. They are also activators of the peroxisome proliferator activated receptor gamma in adipose tissue. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat and hence the capacity of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051014
更新日期:1998-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Adipose tissue expresses some bioactive molecules, which may be involved in the development of obesity-associated metabolic disorders and cardiovascular diseases. Vascular endothelial growth factor (VEGF) an important angiogenic factor is implicated in normal and pathological vessel formation. The aim o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1221-6
更新日期:2003-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0847-1
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is considered to be a risk factor for diabetes and coronary heart disease and is determined by the interaction between genetic and environmental factors. The SstI polymorphism in the apolipoprotein C-III gene has been related to the presence of different features of the insulin resist...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0884-8
更新日期:2002-08-01 00:00:00