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Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects.

Abstract：

AIMS/HYPOTHESIS:Currently, three categories of cardiovascular autonomic nervous function measures are used: classic Ewing-test measures, measures of heart-rate variability (HRV), and measures of baroreflex sensitivity (BRS). Little is known about the agreement between these measures, and reference and reproducibility values for these measures have not been reported within the same group. METHODS:As part of the Hoorn Study, 631 subjects aged 50 to 75 participated in a study of autonomic nervous function. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during spontaneous breathing, during six deep breaths over 1 min, and during an active change in position from lying to standing. From these readings, ten measures of autonomic function were assessed (mean heart rate, three Ewing test measures, five HRV measures and one BRS measure). RESULTS:Regression analysis in a healthy subgroup (n=191) showed sex differences for two of the ten measures and seven measures decreased with age. Therefore, appropriate age-specific and sex-specific reference values were calculated. Reproducibility (n=39) of most measures was moderate, with a reliability coefficient of around 50%. Agreement between the measures of autonomic nervous function varied greatly, between 0% and 87%. The HRV-power ratio measure and the blood pressure changes in the lying-to-standing test showed the lowest agreement with all other measures. CONCLUSION/INTERPRETATION:This study provides age-specific and sex-specific reference values for a wide range of different autonomic function measures in an elderly population. Agreement among the different measures varied widely and reproducibility was only moderate.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Gerritsen J,TenVoorde BJ,Dekker JM,Kingma R,Kostense PJ,Bouter LM,Heethaar RM

doi

10.1007/s00125-003-1032-9

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

330-8

issue

eissn

0012-186X

issn

1432-0428

journal_volume

pub_type

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Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects.