The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy.

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

journal_title：Diabetologia

authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

更新日期：2005-05-01 00:00:00

abstract：:Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...

journal_title：Diabetologia

authors： Kobbah AM,Ewald U,Tuvemo T

更新日期：1989-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...

journal_title：Diabetologia

authors： Melander A,Folino-Gallo P,Walley T,Schwabe U,Groop PH,Klaukka T,Vallano A,Laporte JR,Gallego MR,Schiappa M,Røder M,Kampmann JP,de Swaef A,Aberg M,Månsson NO,Lindblad U

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...

journal_title：Diabetologia

authors： Agersø H,Jensen LB,Elbrønd B,Rolan P,Zdravkovic M

更新日期：2002-02-01 00:00:00

abstract：:The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...

journal_title：Diabetologia

authors： Nair KS,Halliday D,Garrow JS

更新日期：1984-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS), the most common hormonal disorder among women of reproductive age, has various metabolic and reproductive consequences. Metformin was originally shown to lower testosterone levels in women with PCOS in the 1990s, an effect presumably related to its insulin sensitising actions. However...

journal_title：Diabetologia

authors： Sam S,Ehrmann DA

更新日期：2017-09-01 00:00:00

abstract：:Three members of the angiopoietin-like (ANGPTL) family of proteins, ANGPTL3, ANGPTL4 and ANGPTL8, are known regulators of plasma triacylglycerol levels. Recently, these three proteins have garnered considerable interest as potential targets for therapeutically reducing plasma triacylglycerol levels and improving cardi...

journal_title：Diabetologia

authors： Davies BSJ

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of this work were to assess glycaemic control in metformin users receiving their first add-on glucose-lowering therapy and to examine the real-life effectiveness of different add-on drugs. METHODS:We carried out a population-based cohort study using healthcare databases in northern Denmark dur...

journal_title：Diabetologia

authors： Thomsen RW,Baggesen LM,Søgaard M,Pedersen L,Nørrelund H,Buhl ES,Haase CL,Johnsen SP

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：:The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80,267, glucose-induced insulin secretion was reduced 50-60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol ki...

journal_title：Diabetologia

authors： Capito K,Hansen SE,Hedeskov CJ,Thams P

更新日期：1989-02-01 00:00:00

abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

journal_title：Diabetologia

authors： Sakura H,Ashcroft FM

更新日期：1997-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we investigate whether sphingolipid metabolism may contribute to the pathogenesis of human type 1 diabetes ...

journal_title：Diabetologia

authors： Holm LJ,Krogvold L,Hasselby JP,Kaur S,Claessens LA,Russell MA,Mathews CE,Hanssen KF,Morgan NG,Koeleman BPC,Roep BO,Gerling IC,Pociot F,Dahl-Jørgensen K,Buschard K

更新日期：2018-07-01 00:00:00

abstract：:To study the effects on the fetus of variations in maternal glucose tolerance, a 25 g rapid intravenous glucose tolerance test was performed at or about 32 weeks gestation in 917 randomly selected nondiabetic women with singleton pregnancies. The results were withheld from the patients and their obstetricians and paed...

journal_title：Diabetologia

authors： Farmer G,Russell G,Hamilton-Nicol DR,Ogenbede HO,Ross IS,Pearson DW,Thom H,Kerridge DF,Sutherland HW

更新日期：1988-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...

journal_title：Diabetologia

authors： Magee GM,Bilous RW,Cardwell CR,Hunter SJ,Kee F,Fogarty DG

更新日期：2009-04-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：:This study aimed at evaluating the influence of furosemide upon insulin and glucagon responses to arginine in healthy subjects. For this purpose, six normal subjects received two consecutive arginine pulses (3 g), 60 min apart, before and after the administration of furosemide (40 mg, IV). The acute insulin response (...

journal_title：Diabetologia

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1980-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:According to the foetal origins hypothesis, there is a relation between foetal nutrition and adult glucose intolerance. In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. We examined whether the availability of polyunsaturated fatty acids during foetal life, as i...

journal_title：Diabetologia

authors： Rump P,Popp-Snijders C,Heine RJ,Hornstra G

更新日期：2002-03-01 00:00:00

abstract：:The Schwabing Insulin Prophylaxis Trial is a randomised, controlled pilot study designed to examine whether insulin therapy can delay or prevent the clinical onset of Type I diabetes in high risk first degree relatives of people with the disease. First degree relatives of patients with Type I diabetes, who were aged 4...

journal_title：Diabetologia

authors： Füchtenbusch M,Rabl W,Grassl B,Bachmann W,Standl E,Ziegler AG

更新日期：1998-05-01 00:00:00

abstract：:The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...

journal_title：Diabetologia

authors： Vestergaard H,Andersen PH,Lund S,Vedel P,Pedersen O

更新日期：1994-01-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in high glucose-induced collagen elaboration by mesangial cells. METHODS:Primary rat mesangial cells were trea...

journal_title：Diabetologia

authors： Wu D,Peng F,Zhang B,Ingram AJ,Gao B,Krepinsky JC

更新日期：2007-09-01 00:00:00

abstract：:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...

journal_title：Diabetologia

authors： Hart WM,Espinosa C,Rovira J

更新日期：1997-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...

journal_title：Diabetologia

authors： De Grijse J,Asanghanwa M,Nouthe B,Albrecher N,Goubert P,Vermeulen I,Van Der Meeren S,Decochez K,Weets I,Keymeulen B,Lampasona V,Wenzlau J,Hutton JC,Pipeleers D,Gorus FK,Belgian Diabetes Registry.

更新日期：2010-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...

journal_title：Diabetologia

authors： Karlsson MG,Lawesson SS,Ludvigsson J

更新日期：2000-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...

journal_title：Diabetologia

authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

更新日期：2014-10-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00