The influence of maternal glucose metabolism on fetal growth, development and morbidity in 917 singleton pregnancies in nondiabetic women.

abstract：AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...

journal_title：Diabetologia

authors： Qu HQ,Marchand L,Grabs R,Polychronakos C

更新日期：2008-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

journal_title：Diabetologia

authors： Jiang Y,Jakobsen J

更新日期：2004-09-01 00:00:00

abstract：:High levels of gluconeogenic precursors have been reported in patients with long-term diabetes secondary to total pancreatectomy. In the present study, blood concentrations of alanine, lactate and pyruvate were measured in six patients undergoing total pancreatectomy and in nine control subjects undergoing major abdom...

journal_title：Diabetologia

authors： Del Prato S,Vigili de Kreutzenberg S,Trevisan R,Duner E,Avogaro A,Nosadini R,Baccaglini U,Tremolada C,Tiengo A

更新日期：1985-05-01 00:00:00

abstract：:While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation (HFH) and cardiovascular and all-cause deaths in patients treated with empagliflozin were highly impres...

journal_title：Diabetologia

authors： Sattar N,McLaren J,Kristensen SL,Preiss D,McMurray JJ

更新日期：2016-07-01 00:00:00

abstract：:N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor alpha (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velo...

journal_title：Diabetologia

authors： Sagara M,Satoh J,Wada R,Yagihashi S,Takahashi K,Fukuzawa M,Muto G,Muto Y,Toyota T

更新日期：1996-03-01 00:00:00

abstract：:To determine whether increased oxidative stress in diabetes mellitus is due to an impaired free-radical scavenger function in endothelial cells, GSH-dependent H2O2 degradation in human umbilical vein endothelial cells was studied. The GSH-dependent, NaN3-uninhibitable H2O2-degradation in endothelial cells was reduced ...

journal_title：Diabetologia

authors： Kashiwagi A,Asahina T,Ikebuchi M,Tanaka Y,Takagi Y,Nishio Y,Kikkawa R,Shigeta Y

更新日期：1994-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations. No studies to date have investig...

journal_title：Diabetologia

authors： Bulman MP,Harries LW,Hansen T,Shepherd M,Kelly WF,Hattersley AT,Ellard S

更新日期：2002-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence ...

journal_title：Diabetologia

authors： Tikkanen-Dolenc H,Wadén J,Forsblom C,Harjutsalo V,Thorn LM,Saraheimo M,Elonen N,Rosengård-Bärlund M,Gordin D,Tikkanen HO,Groop PH,FinnDiane Study Group.

更新日期：2017-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes...

journal_title：Diabetologia

authors： Howson JM,Dunger DB,Nutland S,Stevens H,Wicker LS,Todd JA

更新日期：2007-04-01 00:00:00

abstract：:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...

journal_title：Diabetologia

authors： Sasaki A

更新日期：1981-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...

journal_title：Diabetologia

authors： Ogihara T,Asano T,Katagiri H,Sakoda H,Anai M,Shojima N,Ono H,Fujishiro M,Kushiyama A,Fukushima Y,Kikuchi M,Noguchi N,Aburatani H,Gotoh Y,Komuro I,Fujita T

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined the association of prevalent and incident cardiovascular disease (CVD) with chronic liver disease in a cohort of community-based people with type 2 diabetes, in order to clarify the relationship between these two important conditions. METHODS:1,066 participants with type 2 diabetes aged 60-...

journal_title：Diabetologia

authors： Morling JR,Fallowfield JA,Williamson RM,Robertson CM,Glancy S,Guha IN,Strachan MW,Price JF

更新日期：2015-07-01 00:00:00

abstract：:Data are discussed which demonstrate that insulin plays an important role in sodium metabolism. The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect...

journal_title：Diabetologia

authors： DeFronzo RA

更新日期：1981-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：:The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...

journal_title：Diabetologia

authors： Yki-Järvinen H

更新日期：1995-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...

journal_title：Diabetologia

authors： Tanaka T,Itoh H,Doi K,Fukunaga Y,Hosoda K,Shintani M,Yamashita J,Chun TH,Inoue M,Masatsugu K,Sawada N,Saito T,Inoue G,Nishimura H,Yoshimasa Y,Nakao K

更新日期：1999-06-01 00:00:00

abstract：:Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with...

journal_title：Diabetologia

authors： Rüger BM,Hasan Q,Greenhill NS,Davis PF,Dunbar PR,Neale TJ

更新日期：1996-10-01 00:00:00

abstract：:The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...

journal_title：Diabetologia

authors： Kellerer M,Sesti G,Seffer E,Obermaier-Kusser B,Pongratz DE,Mosthaf L,Häring HU

更新日期：1993-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Direct infection of beta cells could explain the diabetogenic effect of enteroviruses. Primary adult human beta cells are susceptible to coxsackievirus infections, which could result in impaired beta-cell function or cell death (coxsackieviruses B3, B4, B5) or both, or no apparent immediate adverse effe...

journal_title：Diabetologia

authors： Roivainen M,Ylipaasto P,Savolainen C,Galama J,Hovi T,Otonkoski T

更新日期：2002-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...

journal_title：Diabetologia

authors： Holness MJ,Smith ND,Greenwood GK,Sugden MC

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

journal_title：Diabetologia

authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

journal_title：Diabetologia

authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

更新日期：2013-10-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Prolactin, a multifunctional hormone, is involved in regulating insulin sensitivity and glucose homeostasis in experimental studies. However, whether circulating concentrations of prolactin are associated with risk of type 2 diabetes remains uncertain. METHODS:We analysed the prospective relationship b...

journal_title：Diabetologia

authors： Li J,Rice MS,Huang T,Hankinson SE,Clevenger CV,Hu FB,Tworoger SS

更新日期：2018-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

journal_title：Diabetologia

authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

更新日期：2020-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neurogenin 3 (NEUROG3), a basic helix-loop-helix transcription factor that is needed for endocrine cell development in the embryonic pancreas, has been shown to induce transdifferentiation of duct cells from adult pancreas towards a neuro-endocrine phenotype. Our study explored the endocrine transdiffer...

journal_title：Diabetologia

authors： Harb G,Heremans Y,Heimberg H,Korbutt GS

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy (DCM) is associated with suppressed autophagy and augmented apoptosis in the heart although the interplay between the two remains elusive. The ability of mammalian sterile 20-like kinase 1 to regulate both autophagy and apoptosis prompted us to investigate it as a possible candid...

journal_title：Diabetologia

authors： Zhang M,Zhang L,Hu J,Lin J,Wang T,Duan Y,Man W,Feng J,Sun L,Jia H,Li C,Zhang R,Wang H,Sun D

更新日期：2016-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...

journal_title：Diabetologia

authors： Li B,Yu Y,Liu K,Zhang Y,Geng Q,Zhang F,Li Y,Qi J

更新日期：2021-01-01 00:00:00