Abstract:
AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and rs984971589, in 589 type 1 diabetes nuclear family trios (1,767 individuals). RESULTS:This study independently replicated the reported genetic association using a family-based approach. CONCLUSIONS/INTERPRETATION:The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, i.e. FAP, IFIH1 and GCA. Further variant discovery and fine mapping could help clarify a novel type 1 diabetes mechanism.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Qu HQ,Marchand L,Grabs R,Polychronakos Cdoi
10.1007/s00125-007-0895-6subject
Has Abstractpub_date
2008-03-01 00:00:00pages
473-5issue
3eissn
0012-186Xissn
1432-0428journal_volume
51pub_type
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