Abstract:
:Diabetic retinopathy was found to be present in 12 out of a group of 67 diabetic patients supervised by us during 92 pregnancies, and 3 further pregnant diabetics were referred to us because of retinopathy. The mean duration of diabetes was 13 years (range 3--25 years). Nine patients had minimal retinopathy, 2 had background retinopathy, and the remaining 4 proliferative retinopathy. The cases with minimal retinopathy showed no progression during pregnancy. In 1 patient with background retinopathy there was deterioration. Of the 4 patients with proliferative retinopathy 1 showed regression during the pregnancy, 2 showed advance and were treated with photocoagulation (these 2 patients now have normal vision), while the patient with extensive retinitis proliferans, with retinal detachment in both eyes and previous photocoagulation remained unchanged. The prognosis during pregnancy for patients with diabetic retinopathy is reasonable and has been improved by the advent of photocoagulation.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Cassar J,Kohner EM,Hamilton AM,Gordon H,Joplin GFdoi
10.1007/BF00422254subject
Has Abstractpub_date
1978-08-01 00:00:00pages
105-11issue
2eissn
0012-186Xissn
1432-0428journal_volume
15pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4086-1
更新日期:2016-12-01 00:00:00
abstract::A follow-up study was carried out to determine whether reduced fetal growth is associated with the development of impaired glucose tolerance in men and women aged 50 years. Standard oral glucose tolerance tests were carried out on 140 men and 126 women born in Preston (Lancashire, UK) between 1935 and 1943, whose size...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399954
更新日期:1993-03-01 00:00:00
abstract::To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00420978
更新日期:1976-08-01 00:00:00
abstract::The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253862
更新日期:1982-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-3948-x
更新日期:2016-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3375-9
更新日期:2014-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1508-2
更新日期:2004-10-01 00:00:00
abstract::The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/BF00304849
更新日期:1984-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0631-2
更新日期:2007-06-01 00:00:00
abstract::The adrenergic regulation of adipose tissue lipolysis in response to insulin-induced hypoglycaemia (intravenous infusion of soluble insulin 0.10 IU.kg body weight-1.h-1 until the arterial plasma glucose fell below 2.8 mmol/l) was investigated directly in vivo in 11 insulin-dependent diabetic (IDDM) patients and 12 con...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050519
更新日期:1996-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4568-4
更新日期:2018-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a ho...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0276-6
更新日期:2006-07-01 00:00:00
abstract::Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219741
更新日期:1979-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By m...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051686
更新日期:2001-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1784-y
更新日期:2010-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:We tested the hypothesis that silent coeliac disease is more frequent than expected in both patients with Type I (insulin-dependent) diabetes mellitus and their first-degree relatives. We evaluated how the presence of other autoimmune disorders in diabetic patients and their first-degree relatives is re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051593
更新日期:2001-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/pl00002939
更新日期:2001-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1064-1
更新日期:2003-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. METHODS:Male Holtzman rats of 6 to 8 weeks of age and weighing 170+/-30 g were randomly divided into four groups: control ( n=13), untreated ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1234-1
更新日期:2003-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s001250100571
更新日期:2001-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0075-5
更新日期:2006-01-01 00:00:00
abstract::Diabetes affects 4 to 5% of the population worldwide and is the most common metabolic disorder. The number of individuals diagnosed with diabetes is rapidly increasing, especially in the developed countries and the disorder frequently leads to secondary complications such as retinopathy, nephropathy, neuropathy and ca...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250100623
更新日期:2001-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the effects of oxygen consumption-matched short-term interval walking training (IWT) vs continuous walking training (CWT) on glycaemic control, including glycaemic variability, in individuals with type 2 diabetes. We also assessed whether any training-induced improv...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-016-4170-6
更新日期:2017-03-01 00:00:00
abstract::The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA probes in 131 Caucasia...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00405085
更新日期:1991-04-01 00:00:00
abstract::The characteristics of familial Type I (insulin-dependent) diabetes mellitus-that is Type I diabetes in a first degree relative were investigated for children diagnosed before the age of 15 years using data from an international network of population-based registries (the EURODIAB ACE network) and from a case-control ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051044
更新日期:1998-10-01 00:00:00
abstract::The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i.v. glucose in normal subjects but not in chemica...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429842
更新日期:1975-04-01 00:00:00
abstract::People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1454-0
更新日期:2009-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05017-2
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-006-0340-2
更新日期:2006-09-01 00:00:00
abstract::A recent report has shown an association between a specific Xba1 restriction fragment of the human HepG2-Erythrocyte glucose transporter gene and Type 2 (non-insulin dependent) diabetes. To further examine the significance of this finding we have studied Type 2 diabetic pedigrees for linkage between the Xba1 alleles o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00285296
更新日期:1989-04-01 00:00:00