Assessment of the new criteria for diabetes mellitus according to 10-year relative survival rates.

Abstract:

:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (serum glucose determined by a ferricyanide method). Subjects were classified using the new criteria. The prognosis of normal subjects (fasting glucose less than 140 mg/dl (7.8 mmol/l) and 2-hour glucose level less than 140 mg/dl) and of subjects with fasting glucose less than 140 mg/dl and 2-h 140-200 mg/dl (7.8-11.1 mmol/l) did not differ from that of the general population. Diabetics (fasting greater than or equal to 140 mg/dl and 2-h greater than or equal to 200 mg/dl) showed a significantly reduced survival rate, corresponding to an excess mortality. Subjects with a fasting level less than 140 mg/dl and 2-h greater than or equal to 200 mg/dl had a relative survival rate similar to that of normal subjects. As a group, fasting levels greater than or equal to 140 mg/dl indicated a reduced survival rate, regardless of the 2-h level, while those with a 2-h level greater than or equal to 200 mg/dl alone failed to show a significantly reduced survival rate. Thus, the fasting glucose values appeared to be more closely related to death rate than the 2-hour glucose values.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Sasaki A

doi

10.1007/BF00252627

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

195-8

issue

3

eissn

0012-186X

issn

1432-0428

journal_volume

20

pub_type

杂志文章
  • Clinical and subclinical organ-specific autoimmune manifestations in type 1 (insulin-dependent) diabetic patients and their first-degree relatives.

    abstract::Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00262215

    authors: Betterle C,Zanette F,Pedini B,Presotto F,Rapp LB,Monciotti CM,Rigon F

    更新日期:1984-06-01 00:00:00

  • HbA(1c) and birthweight in women with pre-conception type 1 and type 2 diabetes: a population-based cohort study.

    abstract:AIMS/HYPOTHESIS:To investigate clinical and sociodemographic predictors of birthweight in singletons born to women with type 1 or type 2 diabetes. METHODS:Normally formed singleton live births and intrapartum stillbirths, born to women with pre-conception diabetes during 1996-2008, were identified from the population-...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-012-2721-z

    authors: Glinianaia SV,Tennant PW,Bilous RW,Rankin J,Bell R

    更新日期:2012-12-01 00:00:00

  • Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications.

    abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-005-1710-x

    authors: Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

    更新日期:2005-05-01 00:00:00

  • Nerve growth factor supplementation reverses the impairment, induced by Type 1 diabetes, of hindlimb post-ischaemic recovery in mice.

    abstract:AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-004-1424-5

    authors: Salis MB,Graiani G,Desortes E,Caldwell RB,Madeddu P,Emanueli C

    更新日期:2004-06-01 00:00:00

  • Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes.

    abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-008-1036-6

    authors: Rozo AV,Vijayvargia R,Weiss HR,Ruan H

    更新日期:2008-08-01 00:00:00

  • Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins.

    abstract::We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00252411

    authors: Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

    更新日期:1984-03-01 00:00:00

  • A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

    abstract::Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250051026

    authors: Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

    更新日期:1998-09-01 00:00:00

  • Characterisation of the effect of intravenous infusion of glucose and tolbutamide on the insulin delivery rate in man.

    abstract::Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238 +/- 0.005 min-1 ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00421232

    authors: Asano T,Sasaki H,Okumura M

    更新日期:1978-09-01 00:00:00

  • Lack of gastrointestinal glucagon response to hypoglycaemia in depancreatized dogs.

    abstract::Fasting (24 h) normal dogs and depancreatized dogs were injected intravenously with highly purified porcine insulin (Actrapid) in the doses of 0.2 U/kg and 0.5 U/kg, respectively. Blood glucose decreased from 152 +/- 41 (SEM) mg/100 ml to 39 +/- 7 mg/100 ml in the depancreatized dog and from 95 +/- 3 mg/100 ml to 42 +...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF02342872

    authors: Matsuyama T,Tanaka R,Shima K,Nonaka K,Tarui S

    更新日期:1978-12-01 00:00:00

  • Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05029-y

    authors: Sayers SR,Beavil RL,Fine NHF,Huang GC,Choudhary P,Pacholarz KJ,Barran PE,Butterworth S,Mills CE,Cruickshank JK,Silvestre MP,Poppitt SD,McGill AT,Lavery GG,Hodson DJ,Caton PW

    更新日期:2020-02-01 00:00:00

  • Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity.

    abstract:AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-010-1721-0

    authors: Jacobs-Tulleneers-Thevissen D,Bartholomeus K,Suenens K,Vermeulen I,Ling Z,Hellemans KH,In't Veld P,Pipeleers-Marichal M,Pipeleers D

    更新日期:2010-08-01 00:00:00

  • Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0912-9

    authors: Achenbach P,Bonifacio E,Williams AJ,Ziegler AG,Gale EA,Bingley PJ,ENDIT Group.

    更新日期:2008-03-01 00:00:00

  • Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.

    abstract::Recently, we described a leprechaun patient with a genetically transmitted severe insulin resistance due to the absence of functional insulin receptors as inferred from the loss of insulin binding to the patients' fibroblasts and the impaired autophosphorylation of the beta-chain of the receptor. This patient was homo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00274534

    authors: Lekanne Deprez RH,Potter van Loon BJ,van der Zon GC,Möller W,Lindhout D,Klinkhamer MP,Krans HM,Maassen JA

    更新日期:1989-10-01 00:00:00

  • Differences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabetics.

    abstract::498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01219704

    authors: Herman JB,Medalie JH,Goldbourt U

    更新日期:1977-05-01 00:00:00

  • Axonal transport of noradrenaline and noradrenergic transmission in rats with streptozotocin-induced diabetes.

    abstract::The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00283753

    authors: Tomlinson DR,Gillon KR,Smith MG

    更新日期:1982-03-01 00:00:00

  • Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

    abstract:AIMS/HYPOTHESIS:A natural cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant, alpha-lipoic acid improves glucose metabolism in people with Type II (non-insulin-dependent) diabetes mellitus and in animal models of diabetes. In this study we investigated the cellular mechanism of action of alpha-l...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s001250050047

    authors: Yaworsky K,Somwar R,Ramlal T,Tritschler HJ,Klip A

    更新日期:2000-03-01 00:00:00

  • Family history of myocardial infarction, stroke and diabetes and cardiometabolic markers in children.

    abstract:AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-016-3988-2

    authors: Berentzen NE,Wijga AH,van Rossem L,Koppelman GH,van Nieuwenhuizen B,Gehring U,Spijkerman AM,Smit HA

    更新日期:2016-08-01 00:00:00

  • Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.

    abstract:AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05115-6

    authors: Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

    更新日期:2020-06-01 00:00:00

  • Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study.

    abstract:AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...

    journal_title:Diabetologia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00125-004-1628-8

    authors: Schram MT,Chaturvedi N,Schalkwijk CG,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期:2005-02-01 00:00:00

  • Prognostic impact of the ankle-brachial index on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro Type 2 Diabetes Cohort Study.

    abstract:AIMS/HYPOTHESIS:The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS:The ABI was measured at baseline in ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-018-4709-9

    authors: Cardoso CRL,Melo JV,Salles GC,Leite NC,Salles GF

    更新日期:2018-11-01 00:00:00

  • Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00125-001-0763-8

    authors: Luik PT,Hoogenberg K,Van Der Kleij FG,Beusekamp BJ,Kerstens MN,De Jong PE,Dullaart RP,Navis GJ

    更新日期:2002-04-01 00:00:00

  • Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids.

    abstract:AIMS/HYPOTHESIS:According to the foetal origins hypothesis, there is a relation between foetal nutrition and adult glucose intolerance. In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. We examined whether the availability of polyunsaturated fatty acids during foetal life, as i...

    journal_title:Diabetologia

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00125-001-0764-7

    authors: Rump P,Popp-Snijders C,Heine RJ,Hornstra G

    更新日期:2002-03-01 00:00:00

  • A follow-up of 93 newly diagnosed African diabetics for 6 years.

    abstract::In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00290487

    authors: Castle WM,Wicks AC

    更新日期:1980-01-01 00:00:00

  • Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals.

    abstract:AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-4813-5

    authors: Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

    更新日期:2019-04-01 00:00:00

  • Incidence, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus in Denmark.

    abstract::The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF01223266

    authors: Christau B,Kromann H,Andersen OO,Christy M,Buschard K,Arnung K,Kristensen IH,Peitersen B,Steinrud J,Nerup J

    更新日期:1977-08-01 00:00:00

  • Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.

    abstract::Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00400353

    authors: Fong Y,Edelstein D,Wang EA,Brownlee M

    更新日期:1993-09-01 00:00:00

  • Low-density-lipoprotein cholesterol concentrations and risk of incident diabetes: epidemiological and genetic insights from the Framingham Heart Study.

    abstract:AIMS/HYPOTHESIS:Statins and niacin (nicotinic acid) reduce circulating LDL-cholesterol (LDL-C) levels by different mechanisms. Yet, both increase the risk of diabetes mellitus. Our objective was to relate blood LDL-C concentrations and a genetic risk score (GRS) for LDL-C to the risk of incident diabetes in individuals...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-015-3762-x

    authors: Andersson C,Lyass A,Larson MG,Robins SJ,Vasan RS

    更新日期:2015-12-01 00:00:00

  • Murine streptozotocin diabetes: influences of the major histocompatibility complex, genetic background and blood transfusion.

    abstract::Major histocompatibility complex-linked immune response genes are thought to influence susceptibility to induction of both human insulin-dependent diabetes and murine streptozotocin-induced diabetes. To clarify this relationship, we administered streptozotocin intravenously in two doses (120 and 240 mg/kg body weight)...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/BF00275678

    authors: Weber C,Pernis B,Ting W,Rosenkrantz K,Reemtsma K

    更新日期:1984-07-01 00:00:00

  • Adiposity, inflammation and hyperglycaemia in rural and urban Indian men: Coronary Risk of Insulin Sensitivity in Indian Subjects (CRISIS) Study.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-007-0847-1

    authors: Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

    更新日期:2008-01-01 00:00:00

  • Recording of subcutaneous glucose dynamics by a viscometric affinity sensor.

    abstract:AIMS/HYPOTHESIS:To provide a nonenzymatic sensor for glucose monitoring in subcutaneous tissue. METHODS:A continuously working affinity sensor based on the glucose-dependent viscosity of a sensitive liquid containing dextran and concanavalin A has been designed by arranging a microdialysis probe, two flow-resisting ca...

    journal_title:Diabetologia

    pub_type: 临床试验,杂志文章

    doi:10.1007/s001250051637

    authors: Beyer U,Schäfer D,Thomas A,Aulich H,Haueter U,Reihl B,Ehwald R

    更新日期:2001-04-01 00:00:00