Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine.

abstract：:The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and lipid fluxes into and out of the Krebs cycle, which is highly tuned...

journal_title：Diabetologia

authors： Jones JG

更新日期：2016-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

journal_title：Diabetologia

authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

更新日期：1996-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...

journal_title：Diabetologia

authors： Gunnlaugsdottir E,Halldorsdottir S,Klein R,Eiriksdottir G,Klein BE,Benediktsson R,Harris TB,Launer LJ,Aspelund T,Gudnason V,Cotch MF,Jonasson F

更新日期：2012-03-01 00:00:00

abstract：:Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

journal_title：Diabetologia

authors： Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

journal_title：Diabetologia

authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk of type 2 diabetes. We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 di...

journal_title：Diabetologia

authors： Forbes S,Taylor-Robinson SD,Patel N,Allan P,Walker BR,Johnston DG

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:To assess whether self-monitoring of blood glucose (SMBG) is an independent predictor of improved outcome in a community-based cohort of type 2 diabetic patients. MATERIALS AND METHODS:We used longitudinal data from (1) 1,280 type 2 diabetic participants in the observational Fremantle Diabetes Study (F...

journal_title：Diabetologia

authors： Davis WA,Bruce DG,Davis TM

更新日期：2007-03-01 00:00:00

abstract：:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...

journal_title：Diabetologia

authors： Hussain MA,Akalestou E,Song WJ

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic factors have not yet been identified. Here, we aimed to identify novel genetic risk factors for sig...

journal_title：Diabetologia

authors： Burdon KP,Fogarty RD,Shen W,Abhary S,Kaidonis G,Appukuttan B,Hewitt AW,Sharma S,Daniell M,Essex RW,Chang JH,Klebe S,Lake SR,Pal B,Jenkins A,Govindarjan G,Sundaresan P,Lamoureux EL,Ramasamy K,Pefkianaki M,Hykin PG

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is...

journal_title：Diabetologia

authors： Ittner AA,Bertz J,Chan TY,van Eersel J,Polly P,Ittner LM

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

journal_title：Diabetologia

authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

更新日期：2000-02-01 00:00:00

abstract：:[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused intravenously (i.v.) secondary to its binding to circulating albumin. The duration and activity profile of the acylated (A) and NPH (B) insulins were assessed fol...

journal_title：Diabetologia

authors： Radziuk J,Pye S,Bradley B,Braaten J,Vignati L,Roach P,Bowsher R,DiMarchi R,Chance R

更新日期：1998-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied ...

journal_title：Diabetologia

authors： Ahola AJ,Harjutsalo V,Saraheimo M,Forsblom C,Groop PH,FinnDiane Study Group.

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated spinal and peripheral kappa opioid systems in diabetic rats. MATERIALS AND METHODS:Dynorphin A, N-methyl-D-aspartate (NMDA) and kappa opioid receptor (KOR) were measured in spinal cord, dorsal root ganglia, peripheral nerves and foot skin of control and streptozotocin-induced diabetic r...

journal_title：Diabetologia

authors： Jolivalt CG,Jiang Y,Freshwater JD,Bartoszyk GD,Calcutt NA

更新日期：2006-11-01 00:00:00

abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

journal_title：Diabetologia

authors： Köbberling J,Brüggeboes B

更新日期：1980-06-01 00:00:00

abstract：:Structural alterations in arterial extracellular matrix components have been suggested to play a role in the development of arterial disease among patients with diabetes mellitus. This study examines the quantity and quality of collagenous components in aortas from diabetic patients. In order to obtain data about the ...

journal_title：Diabetologia

authors： Rasmussen LM,Ledet T

更新日期：1993-05-01 00:00:00

abstract：:Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...

journal_title：Diabetologia

authors： Kalant N,Leibovici D,Fukushima N,Kuyumjian J,Ozaki S

更新日期：1982-04-01 00:00:00

abstract：:Very low density lipoproteins (VLDL) have an abnormal lipid composition in Type 1 (insulin-dependent) diabetic patients. Since VLDL represent a heterogeneous lipoprotein class, this might be due either to a shift in the distribution or to an abnormal composition of VLDL subclasses or both. In order to investigate thes...

journal_title：Diabetologia

authors： Patti L,Romano G,Di Marino L,Annuzzi G,Mancini M,Riccardi G,Rivellese AA

更新日期：1993-02-01 00:00:00

abstract：AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

journal_title：Diabetologia

authors： Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to investigate the effects of fenofibrate on the pancreatic lipidome, pancre...

journal_title：Diabetologia

authors： Holm LJ,Haupt-Jorgensen M,Giacobini JD,Hasselby JP,Bilgin M,Buschard K

更新日期：2019-12-01 00:00:00

abstract：:Hepatic microsomal glucose-6-phosphatase activity levels and the hepatic output of glucose are increased in diabetes. We have used protein chemistry and immunological techniques to determine the mechanism by which the activity levels of the glucose-6-phosphatase system are increased in streptozotocin-induced diabetic ...

journal_title：Diabetologia

authors： Burchell A,Cain DI

更新日期：1985-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...

journal_title：Diabetologia

authors： Tura A,Chemello G,Szendroedi J,Göbl C,Færch K,Vrbíková J,Pacini G,Ferrannini E,Roden M

更新日期：2018-05-01 00:00:00

abstract：:Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...

journal_title：Diabetologia

authors： Seyer-Hansen K

更新日期：1977-04-01 00:00:00

abstract：:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...

journal_title：Diabetologia

authors： Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

更新日期：1989-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The relationship of androgens to the metabolic syndrome has not been resolved. The polymorphic number of CAG repeats within the androgen receptor gene is inversely associated with the transcriptional activity of target genes. This polymorphism might thus influence testosterone effects on body fat conten...

journal_title：Diabetologia

authors： Zitzmann M,Gromoll J,von Eckardstein A,Nieschlag E

更新日期：2003-01-01 00:00:00

abstract：:Cytokines could contribute to beta-cell damage in Type I diabetes mellitus. The radical nitric oxide, generated by the inducible form of nitric oxide synthase (iNOS), is a potential mediator of cytokine-induced beta-cell dysfunction. In rat pancreatic islets and insulin-producing cell lines, interleukin-1beta (IL-1bet...

journal_title：Diabetologia

authors： Darville MI,Eizirik DL

更新日期：1998-09-01 00:00:00