Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats.

abstract：AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...

journal_title：Diabetologia

authors： Strey CH,Young J,Collier M,Florkowski CM,Shand BI,Scott RS

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：:Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this approach is, however, scant and few pharmacological agents have proved effective enough to become part of routine clinical care. Recent short-term P...

journal_title：Diabetologia

authors： McCrimmon RJ,Henry RR

更新日期：2018-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and op...

journal_title：Diabetologia

authors： Perez VL,Caicedo A,Berman DM,Arrieta E,Abdulreda MH,Rodriguez-Diaz R,Pileggi A,Hernandez E,Dubovy SR,Parel JM,Ricordi C,Kenyon NM,Kenyon NS,Berggren PO

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...

journal_title：Diabetologia

authors： Schram MT,Chaturvedi N,Schalkwijk CG,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

更新日期：2005-02-01 00:00:00

abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

journal_title：Diabetologia

authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

更新日期：1996-10-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：:The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale appl...

journal_title：Diabetologia

authors： Newgard CB,Clark S,BeltrandelRio H,Hohmeier HE,Quaade C,Normington K

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...

journal_title：Diabetologia

authors： Mahendran Y,Jonsson A,Have CT,Allin KH,Witte DR,Jørgensen ME,Grarup N,Pedersen O,Kilpeläinen TO,Hansen T

更新日期：2017-05-01 00:00:00

abstract：:Developmental changes in the plasma insulin response to milk ingestion have been determined in neonatal lambs fed by bottle and in naturally suckled infant rabbits. In lambs at 4 days of age and older plasma insulin increased within 5 min of suckling and declined again before increasing to a second peak 60 to 120 min ...

journal_title：Diabetologia

authors： Porter RJ,Bassett JM

更新日期：1979-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...

journal_title：Diabetologia

authors： Auvinen AM,Luiro K,Jokelainen J,Järvelä I,Knip M,Auvinen J,Tapanainen JS

更新日期：2020-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

journal_title：Diabetologia

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：:The antiprotozoal drug pentamidine can be toxic to islet cells in vivo and in vitro. Rat islets were exposed to pentamidine (mesylate and isethionate salts) and six other structurally related diamidines. The beta-cell response to arginine + theophylline was suppressed by pentamidine (10(-2) mmol/l) while the glucagon ...

journal_title：Diabetologia

authors： Boillot D,in't Veld P,Sai P,Feutren G,Gepts W,Assan R

更新日期：1985-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-lowering therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors is associated with a low risk of hypoglycaemia. We hypothesise that DPP-4 inhibition prevents hypoglycaemia via increased glucagon counterregulation through the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). M...

journal_title：Diabetologia

authors： Malmgren S,Ahrén B

更新日期：2015-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:A common G to A polymorphism ( UCSNP-43) in the Calpain 10 gene was recently found to be associated with Type II (non-insulin-dependent) diabetes mellitus and variations in post-absorptive and insulin stimulated glucose metabolism in vivo. We aimed to study the influence of Calpain 10 polymorphism on in...

journal_title：Diabetologia

authors： Hoffstedt J,Rydén M,Löfgren P,Orho-Melander M,Groop L,Arner P

更新日期：2002-02-01 00:00:00

abstract：:A geographically based sample of 1069 Hispanic and non-Hispanic white persons aged 20-74 years, living in southern Colorado and who tested normal on an oral glucose tolerance test (World Health Organization criteria) were evaluated to determine associations of dietary factors with fasting serum insulin concentrations....

journal_title：Diabetologia

authors： Marshall JA,Bessesen DH,Hamman RF

更新日期：1997-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

journal_title：Diabetologia

authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

更新日期：2012-08-01 00:00:00

abstract：:MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...

journal_title：Diabetologia

authors： Shields B,Colclough K

更新日期：2017-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. METHODS:Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphen...

journal_title：Diabetologia

authors： Ukropec J,Radikova Z,Huckova M,Koska J,Kocan A,Sebokova E,Drobna B,Trnovec T,Susienkova K,Labudova V,Gasperikova D,Langer P,Klimes I

更新日期：2010-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

journal_title：Diabetologia

authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin control of glucose output is a major mechanism by which appropriate amounts of glucose are produced to supply energy to the central nervous system, without causing long-term increases of the plasma glucose concentration. It is hypothesised that the primary route by which insulin maintains contro...

journal_title：Diabetologia

authors： Bergman RN

更新日期：2000-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The process of islet isolation can cause chemical and mechanical injury to beta cells. In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection...

journal_title：Diabetologia

authors： Ahn YB,Xu G,Marselli L,Toschi E,Sharma A,Bonner-Weir S,Sgroi DC,Weir GC

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...

journal_title：Diabetologia

authors： Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

更新日期：2019-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...

journal_title：Diabetologia

authors： Hillman M,Törn C,Thorgeirsson H,Landin-Olsson M

更新日期：2004-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction a...

journal_title：Diabetologia

authors： Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF

更新日期：2011-08-01 00:00:00

abstract：:We investigated whether the glomerular synthesis of prostaglandins modulates the glomerular filtration rate and albuminuria in diabetic nephropathy. The urinary excretion of immunoreactive prostaglandin E2 (253 pg/min) was significantly elevated in eight Type 1 (insulin-dependent) diabetic women with nephropathy as co...

journal_title：Diabetologia

authors： Hommel E,Mathiesen E,Arnold-Larsen S,Edsberg B,Olsen UB,Parving HH

更新日期：1987-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. METHODS:Male Holtzman rats of 6 to 8 weeks of age and weighing 170+/-30 g were randomly divided into four groups: control ( n=13), untreated ...

journal_title：Diabetologia

authors： Bosco AA,Lerario AC,Santos RF,Wajchenberg BL

更新日期：2003-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...

journal_title：Diabetologia

authors： Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

更新日期：2020-03-01 00:00:00