High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail.

abstract：AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...

journal_title：Diabetologia

authors： Casis O,Gallego M,Iriarte M,Sánchez-Chapula JA

更新日期：2000-01-01 00:00:00

abstract：:Most polypeptides originally assigned to a specific organ and a specific effect seem to occur in many different parts of the body, in neurons as well as in endocrine cells. Thus gastrin and insulin, or very similar peptides can be demonstrated in extracts of the vagal nerves and of peripheral somatic nerves. Electrica...

journal_title：Diabetologia

authors： Uvnäs-Wallensten K

更新日期：1981-03-01 00:00:00

abstract：:Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean home capillary blood glucose...

journal_title：Diabetologia

authors： Paisey RB,Harkness J,Hartog M,Chadwick T

更新日期：1980-10-01 00:00:00

abstract：:The relation between urinary albumin excretion rate (UAE), transcapillary escape rate of albumin (TERalb), haemostatic factors, ambulatory blood pressure, and metabolic variables was investigated in 45 Type II (non-insulin-dependent) diabetic patients without overt nephropathy or uncontrolled blood pressure. We enroll...

journal_title：Diabetologia

authors： Nielsen S,Schmitz A,Bacher T,Rehling M,Ingerslev J,Mogensen CE

更新日期：1999-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS:Data were retrieved from the Medical Birth Register of Sweden for wome...

journal_title：Diabetologia

authors： Mattsson K,Källén K,Longnecker MP,Rignell-Hydbom A,Rylander L

更新日期：2013-08-01 00:00:00

abstract：:Type 1 diabetes is an immune-mediated disease leading to almost total beta cell destruction and permanent exogenous insulin dependency. The appearance of clinical symptoms is preceded by an asymptomatic preclinical period, the duration of which is highly individual. The emergence of diabetes-associated autoantibodies ...

journal_title：Diabetologia

authors： Knip M,Selvenius J,Siljander H,Veijola R

更新日期：2017-01-01 00:00:00

abstract：:Diabetic patients exhibit a higher incidence of post-surgical sepsis, as well as a higher rate of mortality from sepsis, than their non-diabetic counterparts. This may be a result of cardiovascular deterioration associated with diabetes mellitus. This study was designed to characterize the cardiovascular sequelae asso...

journal_title：Diabetologia

authors： Law WR,Moriarty MT,McLane MP

更新日期：1991-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in diabetic wounds and (ii) evaluate whether NGF supplementation could prevent impairment of wound neoangiogenesis by diabetes. ...

journal_title：Diabetologia

authors： Graiani G,Emanueli C,Desortes E,Van Linthout S,Pinna A,Figueroa CD,Manni L,Madeddu P

更新日期：2004-06-01 00:00:00

abstract：:The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA probes in 131 Caucasia...

journal_title：Diabetologia

authors： Oelbaum RS,Bouloux PM,Li SR,Baroni MG,Stocks J,Galton DJ

更新日期：1991-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Haffner SM

更新日期：2014-01-01 00:00:00

abstract：:We have investigated whether the previously demonstrated stimulatory actions of growth hormone on DNA synthesis and (pro)insulin biosynthesis and release of isolated adult rat islets of Langerhans are mediated by an autocrine release of somatomedin-C/insulin-like growth factor I (SM-C/IGF I). In medium containing 1% f...

journal_title：Diabetologia

authors： Swenne I,Hill DJ

更新日期：1989-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperinsulinaemia and insulin resistance, as well as low IGF-I, have been implicated in the pathogenesis of cardiovascular disease. Little is known about direct effects of IGF-I and insulin on human coronary artery smooth muscle cells (HCASMCs). Our aim was to characterise the expression and function of...

journal_title：Diabetologia

authors： Chisalita SI,Arnqvist HJ

更新日期：2005-10-01 00:00:00

abstract：:Downregulation of insulin receptor tyrosine kinase (IRK) activity yields to impaired insulin signalling and contributes to the pathogenesis of cellular insulin resistance. Activation of protein kinase C (PKC) by different agents is associated with an inhibition of IRK activity in various cell types. There is evidence ...

journal_title：Diabetologia

authors： Bossenmaier B,Mosthaf L,Mischak H,Ullrich A,Häring HU

更新日期：1997-07-01 00:00:00

abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

journal_title：Diabetologia

authors： Gotfredsen CF

更新日期：1976-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

journal_title：Diabetologia

authors： van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy of m...

journal_title：Diabetologia

authors： Thorens B,Tarussio D,Maestro MA,Rovira M,Heikkilä E,Ferrer J

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...

journal_title：Diabetologia

authors： Tillin T,Forouhi N,Johnston DG,McKeigue PM,Chaturvedi N,Godsland IF

更新日期：2005-04-01 00:00:00

abstract：:Decreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. Dietary supplementation with fish oils has been shown to augment endothelium-dependent relaxations, principally by improving the release of ...

journal_title：Diabetologia

authors： McVeigh GE,Brennan GM,Johnston GD,McDermott BJ,McGrath LT,Henry WR,Andrews JW,Hayes JR

更新日期：1993-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

journal_title：Diabetologia

authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to evaluate factors related to the markedly increased risk of dying from diabetic renal disease in Japanese insulin-dependent diabetic patients compared to those in the USA. The study was based on two population-based cohorts consisting of 1374 cases from Japan and 995 cases from Allegheny Co...

journal_title：Diabetologia

authors： Matsushima M,Tajima N,LaPorte RE,Orchard TJ,Tull ES,Gower IF,Kitagawa T

更新日期：1995-02-01 00:00:00

abstract：:Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...

journal_title：Diabetologia

authors： Shemer J,Penhos JC,LeRoith D

更新日期：1986-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Clinical trials are in progress to test thiazolidinediones in neurodegenerative diseases such as Alzheimer's disease that involve deficiencies in brain glucose metabolism. While thiazolidinediones enhance glucose uptake in non-cerebral tissues, their impact on brain energy metabolism has not been invest...

journal_title：Diabetologia

authors： Galea E,Feinstein DL,Lacombe P

更新日期：2006-09-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...

journal_title：Diabetologia

authors： Catrina SB,Zheng X

更新日期：2021-01-26 00:00:00

abstract：:We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...

journal_title：Diabetologia

authors： Plater ME,Ford I,Dent MT,Preston FE,Ward JD

更新日期：1996-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enterovirus (e.g. Coxsackie B virus serotypes [CVBs]) infections may be associated with development of type 1 diabetes. Studies conducted in several European countries have, however, shown an inverse correlation between the incidence of type 1 diabetes and the prevalence of enterovirus infections. These...

journal_title：Diabetologia

authors： Larsson PG,Lakshmikanth T,Svedin E,King C,Flodström-Tullberg M

更新日期：2013-04-01 00:00:00

abstract：:Loss of neurogenic inflammation in response to tissue injury may be an important complication of diabetes mellitus. We studied local neurogenic inflammation in the peripheral nerve trunk of Sprague-Dawley rats 4 months following the induction of diabetes by streptozotocin injection. To assess neurogenic inflammation, ...

journal_title：Diabetologia

authors： Zochodne DW,Ho LT

更新日期：1993-06-01 00:00:00