Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.

abstract：:D600 (2 to 20 muM; alpha-isopropyl-alpha [(N-methyl-N-homoveratril)-gamma-aminopropyl]-3,4,5-trimethoxyphenyl-acetonitril) caused a dose-related, rapid and reversible inhibition of glucose-induced insulin release. It also suppressed the insulinotropic action of a sulphonylurea but failed to affect the enhancing action...

journal_title：Diabetologia

authors： Malaisse WJ,Devis G,Pipeleers DG,Somers G

更新日期：1976-03-01 00:00:00

abstract：:Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

journal_title：Diabetologia

authors： Carré A,Richardson SJ,Larger E,Mallone R

更新日期：2021-01-01 00:00:00

abstract：:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...

journal_title：Diabetologia

authors： Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns W

更新日期：1980-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration. METHODS:Using prosp...

journal_title：Diabetologia

authors： Franceschini N,Haack K,Göring HH,Voruganti VS,Laston S,Almasy L,Lee ET,Best LG,Fabsitz RR,North KE,Maccluer JW,Meigs JB,Pankow JS,Cole SA

更新日期：2013-10-01 00:00:00

abstract：:The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate c...

journal_title：Diabetologia

authors： Jeppesen J,Zhou MY,Chen YD,Reaven GM

更新日期：1994-08-01 00:00:00

abstract：:Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 +/- 0.15 to 2.83 +/- 0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypogl...

journal_title：Diabetologia

authors： Bolli G,Calabrese G,De Feo P,Compagnucci P,Zega G,Angeletti G,Cartechini MG,Santeusanio F,Brunetti P

更新日期：1982-02-01 00:00:00

abstract：:It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeo...

journal_title：Diabetologia

authors： Wilding JP,Khandan-Nia N,Bennet WM,Gilbey SG,Beacham J,Ghatei MA,Bloom SR

更新日期：1994-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

journal_title：Diabetologia

authors： Larsson SC,Michaëlsson K,Burgess S

更新日期：2020-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:According to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45+ cells are found within the parenchyma or in the islet-exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabete...

journal_title：Diabetologia

authors： Lundberg M,Seiron P,Ingvast S,Korsgren O,Skog O

更新日期：2017-02-01 00:00:00

abstract：:The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...

journal_title：Diabetologia

authors： Christau B,Kromann H,Andersen OO,Christy M,Buschard K,Arnung K,Kristensen IH,Peitersen B,Steinrud J,Nerup J

更新日期：1977-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

journal_title：Diabetologia

authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

更新日期：2011-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...

journal_title：Diabetologia

authors： Carlsson S,Andersson T,Talbäck M,Feychting M

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to evaluate factors related to the markedly increased risk of dying from diabetic renal disease in Japanese insulin-dependent diabetic patients compared to those in the USA. The study was based on two population-based cohorts consisting of 1374 cases from Japan and 995 cases from Allegheny Co...

journal_title：Diabetologia

authors： Matsushima M,Tajima N,LaPorte RE,Orchard TJ,Tull ES,Gower IF,Kitagawa T

更新日期：1995-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Acute hyperglycaemia rapidly suppresses endogenous glucose production (EGP) in non-diabetic individuals, mainly by inhibiting glycogenolysis. Loss of this 'glucose effectiveness' contributes to fasting hyperglycaemia in type 2 diabetes. Elevated NEFA levels characteristic of type 2 diabetes impair gluco...

journal_title：Diabetologia

authors： Kehlenbrink S,Koppaka S,Martin M,Relwani R,Cui MH,Hwang JH,Li Y,Basu R,Hawkins M,Kishore P

更新日期：2012-11-01 00:00:00

abstract：:A recent report has shown an association between a specific Xba1 restriction fragment of the human HepG2-Erythrocyte glucose transporter gene and Type 2 (non-insulin dependent) diabetes. To further examine the significance of this finding we have studied Type 2 diabetic pedigrees for linkage between the Xba1 alleles o...

journal_title：Diabetologia

authors： O'Rahilly S,Patel P,Wainscoat JS,Turner RC

更新日期：1989-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

journal_title：Diabetologia

authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

更新日期：2006-01-01 00:00:00

abstract：:At St. Mary's Hospital Medical School in London, 22 outpatients, 21 women and 1 man, underwent oral glucose tolerance tests. Carbohydrate intake was standardized for 3 days prior to each test. 13 of the women were on oral contraceptive therapy of the combination type. Tests were performed either at 9 AM after a fas...

journal_title：Diabetologia

authors： Oakley NW,Monier D,Wynn V

更新日期：1973-06-01 00:00:00

abstract：:Non-obese diabetic mice were treated daily with a mixture of gangliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80-90% to 47% and from 20-30% to zero in female and male mice respectively. Gangliosides did not affect the frequency of p...

journal_title：Diabetologia

authors： Wilberz S,Herberg L,Renold AE

更新日期：1988-11-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...

journal_title：Diabetologia

authors： Fernyhough P,Diemel LT,Tomlinson DR

更新日期：1998-03-01 00:00:00

abstract：:The mechanisms which underlie the development of Charcot joints and foot ulceration are poorly understood. The present study using non-invasive Doppler techniques demonstrates that in the neuropathic leg, the arteries are rigid, peripheral blood flow is increased and associated with arteriovenous shunting. We studied ...

journal_title：Diabetologia

authors： Edmonds ME,Roberts VC,Watkins PJ

更新日期：1982-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...

journal_title：Diabetologia

authors： Karlsson MG,Lawesson SS,Ludvigsson J

更新日期：2000-06-01 00:00:00

abstract：:The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...

journal_title：Diabetologia

authors： Pennell JP,Millard MM,Ashby MH

更新日期：1981-07-01 00:00:00

abstract：:We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l glucose for 48 h and then glucose transport was studied by measuring the (3H)-2-deoxyglucose uptake for 5 and...

journal_title：Diabetologia

authors： Purrello F,Buscema M,Vetri M,Vinci C,Gatta C,Forte F,Rabuazzo AM,Vigneri R

更新日期：1991-05-01 00:00:00

abstract：:Of 89 pancreas transplants performed in 77 diabetic patients (43 with and 34 without previous kidney transplants), 53 were from cadaver and 36 from related donors. To date, 64 patients (83%) are alive and 27 (35%) have functioning grafts (14 greater than 1 year), including 0 out of 3 duct-ligated, 3 out of 15 open-duc...

journal_title：Diabetologia

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1984-07-01 00:00:00

abstract：:The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When inter...

journal_title：Diabetologia

authors： Wilson GL,Bellomo SC,Craighead JE

更新日期：1983-01-01 00:00:00

abstract：:A geographically based sample of 1069 Hispanic and non-Hispanic white persons aged 20-74 years, living in southern Colorado and who tested normal on an oral glucose tolerance test (World Health Organization criteria) were evaluated to determine associations of dietary factors with fasting serum insulin concentrations....

journal_title：Diabetologia

authors： Marshall JA,Bessesen DH,Hamman RF

更新日期：1997-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS:Participants without dementia aged 55-90 years from the Cognition...

journal_title：Diabetologia

authors： Callisaya ML,Beare R,Moran C,Phan T,Wang W,Srikanth VK

更新日期：2019-03-01 00:00:00

abstract：:An inconsistency has come to light between the conclusion of Lucassen et al. that IDDM2 (11p15.5) must lie within a 4.1 kilobase (kb) segment at the insulin (INS) locus and their own data showing statistically significant associations between insulin-dependent diabetes mellitus (IDDM) and markers beyond the boundaries...

journal_title：Diabetologia

authors： Doria A,Lee J,Warram JH,Krolewski AS

更新日期：1996-05-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：:The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...

journal_title：Diabetologia

authors： Kellerer M,Sesti G,Seffer E,Obermaier-Kusser B,Pongratz DE,Mosthaf L,Häring HU

更新日期：1993-07-01 00:00:00