Effect of interferon on encephalomyocarditis virus infection of cultured mouse pancreatic B cells.

abstract：AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...

journal_title：Diabetologia

authors： Kriz J,Padjen AL

更新日期：2003-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...

journal_title：Diabetologia

authors： Dong YF,Liu L,Kataoka K,Nakamura T,Fukuda M,Tokutomi Y,Nako H,Ogawa H,Kim-Mitsuyama S

更新日期：2010-01-01 00:00:00

abstract：:Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...

journal_title：Diabetologia

authors： Betterle C,Zanette F,Pedini B,Presotto F,Rapp LB,Monciotti CM,Rigon F

更新日期：1984-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...

journal_title：Diabetologia

authors： Törn C,Mueller PW,Schlosser M,Bonifacio E,Bingley PJ,Participating Laboratories.

更新日期：2008-05-01 00:00:00

abstract：:The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...

journal_title：Diabetologia

authors： Gamble DR

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

journal_title：Diabetologia

authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

更新日期：2000-04-01 00:00:00

abstract：:The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...

journal_title：Diabetologia

authors： Hussain MA,Akalestou E,Song WJ

更新日期：2016-04-01 00:00:00

abstract：:Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

journal_title：Diabetologia

authors： Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...

journal_title：Diabetologia

authors： Melander A,Folino-Gallo P,Walley T,Schwabe U,Groop PH,Klaukka T,Vallano A,Laporte JR,Gallego MR,Schiappa M,Røder M,Kampmann JP,de Swaef A,Aberg M,Månsson NO,Lindblad U

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. METHODS:We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the ye...

journal_title：Diabetologia

authors： Knerr I,Wolf J,Reinehr T,Stachow R,Grabert M,Schober E,Rascher W,Holl RW,DPV Scientific Initiative of Germany and Austria.

更新日期：2005-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity. However, information on their associations with type 2 diabetes is limited. Such information could help increase our understand...

journal_title：Diabetologia

authors： Li S,Zhao JH,Luan J,Langenberg C,Luben RN,Khaw KT,Wareham NJ,Loos RJ

更新日期：2011-04-01 00:00:00

abstract：:Fifty-nine Type 1 (insulin-dependent) diabetic patients with (group I) and 59 patients without nephropathy (group II) pair-matched according to sex (30 males and 29 females), age (33 years, range 15-48) and diabetes duration (19 years, range 6-42) were followed for a period of 10 years from about 5 years before to 5 y...

journal_title：Diabetologia

authors： Jensen T,Borch-Johnsen K,Kofoed-Enevoldsen A,Deckert T

更新日期：1987-03-01 00:00:00

abstract：:Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...

journal_title：Diabetologia

authors： Elliott HR,Sharp GC,Relton CL,Lawlor DA

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...

journal_title：Diabetologia

authors： Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

更新日期：2011-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Serum potassium has been found to be a significant predictor of diabetes risk, but the effect of dietary potassium on diabetes risk is not clear. We sought to determine if dietary potassium is associated with risk of incident type 2 diabetes in young adults. METHODS:We used data from the Coronary Arter...

journal_title：Diabetologia

authors： Chatterjee R,Colangelo LA,Yeh HC,Anderson CA,Daviglus ML,Liu K,Brancati FL

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:A common G to A polymorphism ( UCSNP-43) in the Calpain 10 gene was recently found to be associated with Type II (non-insulin-dependent) diabetes mellitus and variations in post-absorptive and insulin stimulated glucose metabolism in vivo. We aimed to study the influence of Calpain 10 polymorphism on in...

journal_title：Diabetologia

authors： Hoffstedt J,Rydén M,Löfgren P,Orho-Melander M,Groop L,Arner P

更新日期：2002-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...

journal_title：Diabetologia

authors： Strey CH,Young J,Collier M,Florkowski CM,Shand BI,Scott RS

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enhanced and prolonged postprandial lipaemia is related to cardiovascular disease but how postprandial lipaemia is regulated is poorly known. We therefore determined the relations of fasting insulin concentrations to fasting and postprandial lipids, lipoproteins and non-esterified fatty acids in middle-...

journal_title：Diabetologia

authors： Boquist S,Hamsten A,Karpe F,Ruotolo G

更新日期：2000-02-01 00:00:00

abstract：:High levels of gluconeogenic precursors have been reported in patients with long-term diabetes secondary to total pancreatectomy. In the present study, blood concentrations of alanine, lactate and pyruvate were measured in six patients undergoing total pancreatectomy and in nine control subjects undergoing major abdom...

journal_title：Diabetologia

authors： Del Prato S,Vigili de Kreutzenberg S,Trevisan R,Duner E,Avogaro A,Nosadini R,Baccaglini U,Tremolada C,Tiengo A

更新日期：1985-05-01 00:00:00

abstract：:Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...

journal_title：Diabetologia

authors： Mohan V,Mohan R,Susheela L,Snehalatha C,Bharani G,Mahajan VK,Ramachandran A,Viswanathan M,Kohner EM

更新日期：1985-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy (DCM) is associated with suppressed autophagy and augmented apoptosis in the heart although the interplay between the two remains elusive. The ability of mammalian sterile 20-like kinase 1 to regulate both autophagy and apoptosis prompted us to investigate it as a possible candid...

journal_title：Diabetologia

authors： Zhang M,Zhang L,Hu J,Lin J,Wang T,Duan Y,Man W,Feng J,Sun L,Jia H,Li C,Zhang R,Wang H,Sun D

更新日期：2016-11-01 00:00:00

abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

journal_title：Diabetologia

authors： Spiro MJ

更新日期：1987-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:As one of the key adipokines, retinol binding protein 4 (RBP4) is suggested to positively correlate with insulin resistance; however, not all clinical studies support this association. Although some explanations are proposed for this discrepancy, the temporal aspect of RBP4 secretion has not been consid...

journal_title：Diabetologia

authors： Ma X,Zhou Z,Chen Y,Wu Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：:Significant progress has been made in recent years in the characterisation of the signal pathways of beta cell dysfunction and death in the pathogenesis of type 2 diabetes. Glucolipotoxicity acts as an exogenous factor whereas oxidative stress and endoplasmic reticulum stress may result from the processes of signal re...

journal_title：Diabetologia

authors： Rustenbeck I,Baltrusch S,Tiedge M

更新日期：2010-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...

journal_title：Diabetologia

authors： Ahmed N,Babaei-Jadidi R,Howell SK,Beisswenger PJ,Thornalley PJ

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

journal_title：Diabetologia

authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

更新日期：2008-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another feature of type 2 diabetes, contributes to impaired glucagon-like pe...

journal_title：Diabetologia

authors： Kang ZF,Deng Y,Zhou Y,Fan RR,Chan JC,Laybutt DR,Luzuriaga J,Xu G

更新日期：2013-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted ...

journal_title：Diabetologia

authors： Winther SA,Henriksen P,Vogt JK,Hansen TH,Ahonen L,Suvitaival T,Hein Zobel E,Frimodt-Møller M,Hansen TW,Hansen T,Parving HH,Legido-Quigley C,Rossing P,Pedersen O

更新日期：2020-12-01 00:00:00