Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes.

abstract：AIMS/HYPOTHESIS:Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes. METHODS:The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individu...

journal_title：Diabetologia

authors： Jansson FJ,Forsblom C,Harjutsalo V,Thorn LM,Wadén J,Elonen N,Ahola AJ,Saraheimo M,Groop PH,FinnDiane Study Group.

更新日期：2018-05-01 00:00:00

abstract：:The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional exper...

journal_title：Diabetologia

authors： Martín F,Moya F,Gutierrez LM,Reig JA,Soria B

更新日期：1995-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...

journal_title：Diabetologia

authors： Karlsson MG,Lawesson SS,Ludvigsson J

更新日期：2000-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...

journal_title：Diabetologia

authors： Christensen GL,Jacobsen ML,Wendt A,Mollet IG,Friberg J,Frederiksen KS,Meyer M,Bruun C,Eliasson L,Billestrup N

更新日期：2015-06-01 00:00:00

abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

journal_title：Diabetologia

authors： Gotfredsen CF

更新日期：1976-08-01 00:00:00

abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

journal_title：Diabetologia

authors： Castle WM,Wicks AC

更新日期：1980-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

journal_title：Diabetologia

authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...

journal_title：Diabetologia

authors： Jiang Y,Jakobsen J

更新日期：2004-09-01 00:00:00

abstract：:The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...

journal_title：Diabetologia

authors： Bereiter DA,Rohner-Jeanrenaud F,Berthoud H-,Jeanrenaud B

更新日期：1981-03-01 00:00:00

abstract：:Among monosaccharides, fructose has a small hyperglycaemic effect. In order to better explain the mechanisms which cause this metabolic property, we used tracers labelled with stable isotopes (deuterated glucose and naturally 13C labelled fructose) to quantify the overall glucose appearance, the rate of appearance in ...

journal_title：Diabetologia

authors： Delarue J,Normand S,Pachiaudi C,Beylot M,Lamisse F,Riou JP

更新日期：1993-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...

journal_title：Diabetologia

authors： Magee GM,Bilous RW,Cardwell CR,Hunter SJ,Kee F,Fogarty DG

更新日期：2009-04-01 00:00:00

abstract：:Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238 +/- 0.005 min-1 ...

journal_title：Diabetologia

authors： Asano T,Sasaki H,Okumura M

更新日期：1978-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:We studied the gene therapy efficacy of diabetes-associated wound healing disorder with an adeno-associated virus (AAV) vector expressing the 165-amino acid isoform of human vascular endothelial growth factor-A (VEGF-A) by using an incisional skin-wound model produced on the back of female diabetic C57B...

journal_title：Diabetologia

authors： Galeano M,Deodato B,Altavilla D,Cucinotta D,Arsic N,Marini H,Torre V,Giacca M,Squadrito F

更新日期：2003-04-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：:In order to assess the possible progression of neurological abnormalities over time and the value of visual evoked potential alterations in predicting stability and severity of diabetes-related optic pathway disease, a longitudinal study in non-insulin-dependent diabetic patients was performed. Neurological examinatio...

journal_title：Diabetologia

authors： Moreo G,Mariani E,Pizzamiglio G,Colucci GB

更新日期：1995-05-01 00:00:00

abstract：:Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...

journal_title：Diabetologia

authors： Rasch R

更新日期：1984-07-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：:Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

journal_title：Diabetologia

authors： Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：:In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before th...

journal_title：Diabetologia

authors： Hernández-Sánchez C,Mansilla A,de la Rosa EJ,de Pablo F

更新日期：2006-06-01 00:00:00

abstract：:The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...

journal_title：Diabetologia

authors： Tomlinson DR

更新日期：1999-11-01 00:00:00

abstract：:The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...

journal_title：Diabetologia

authors： Bader S,Scholz R,Kellerer M,Tippmer S,Rett K,Mathaei S,Freund P,Häring HU

更新日期：1992-08-01 00:00:00

abstract：:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...

journal_title：Diabetologia

authors： Elliott RB,Chase HP

更新日期：1991-05-01 00:00:00

abstract：:New treatment strategies for subjects with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus are being developed. Pilot studies utilising insulin itself have been reported to prevent Type 1 diabetes in subjects likely, by immunogenetic and physiologic criteria, to develop clinically overt...

journal_title：Diabetologia

authors： Robertson RP,Klein DJ

更新日期：1992-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...

journal_title：Diabetologia

authors： Barbosa-Sampaio HC,Liu B,Drynda R,Rodriguez de Ledesma AM,King AJ,Bowe JE,Malicet C,Iovanna JL,Jones PM,Persaud SJ,Muller DS

更新日期：2013-11-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：:Insulin binding and the effect of insulin on the transport of 3-O-methylglucose, lipogenesis from glucose, glucose oxidation and lipolysis was studied in fat cells of adrenalectomised rats and of a control group of sham-operated rats. The serum insulin level of the adrenalectomised rats (0.7 ng/ml) was lower than that...

journal_title：Diabetologia

authors： Häring H,Calle C,Bug A,Renner R,Hepp KD,Kemmler W

更新日期：1980-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...

journal_title：Diabetologia

authors： Yanagimachi T,Fujita Y,Takeda Y,Honjo J,Atageldiyeva KK,Takiyama Y,Abiko A,Makino Y,Kieffer TJ,Haneda M

更新日期：2016-03-01 00:00:00