Abstract:
:The role of syntaxin 1, a protein involved in the docking of synaptic vesicles at presynaptic active zones, has been investigated in pancreatic islet cells. Using two different monoclonal antibodies we have shown that syntaxin 1 is present in the pancreatic islet cell microsomal fraction. Furthermore, functional experiments demonstrate that anti-syntaxin antibodies inhibit CA(2+)-dependent insulin secretion in permeabilized islet cells. These data indicate that syntaxin 1 is present in the pancreatic beta cell and it is likely to play a functional role in the exocytosis of secretory granules.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Martín F,Moya F,Gutierrez LM,Reig JA,Soria Bdoi
10.1007/s001250050364subject
Has Abstractpub_date
1995-07-01 00:00:00pages
860-3issue
7eissn
0012-186Xissn
1432-0428journal_volume
38pub_type
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