Abstract:
AIMS/HYPOTHESIS:The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI). METHODS:We examined the effects of olmesartan, an ARB, on primary composite outcome of doubling of serum creatinine, endstage renal disease and death in type 2 diabetic patients with overt nephropathy. Secondary outcome included composite cardiovascular outcomes, changes in renal function and proteinuria. Randomisation and allocation to trial group were carried out by a central computer system. Participants, caregivers, the people carrying out examinations and people assessing the outcomes were blinded to group assignment. RESULTS:Five hundred and seventy-seven (377 Japanese, 200 Chinese) patients treated with antihypertensive therapy (73.5% [n = 424] received concomitant ACEI), were given either once-daily olmesartan (10-40 mg) (n = 288) or placebo (n = 289) over 3.2 ± 0.6 years (mean±SD). In the olmesartan group, 116 developed the primary outcome (41.1%) compared with 129 (45.4%) in the placebo group (HR 0.97, 95% CI 0.75, 1.24; p = 0.791). Olmesartan significantly decreased blood pressure, proteinuria and rate of change of reciprocal serum creatinine. Cardiovascular death was higher in the olmesartan group than the placebo group (ten vs three cases), whereas major adverse cardiovascular events (cardiovascular death plus non-fatal stroke and myocardial infarction) and all-cause death were similar between the two groups (major adverse cardiovascular events 18 vs 21 cases, all-cause deaths; 19 vs 20 cases). Hyperkalaemia was more frequent in the olmesartan group than the placebo group (9.2% vs 5.3%). CONCLUSIONS/INTERPRETATION:Olmesartan was well tolerated but did not improve renal outcome on top of ACEI. TRIAL REGISTRATION:ClinicalTrials.gov NCT00141453.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Imai E,Chan JC,Ito S,Yamasaki T,Kobayashi F,Haneda M,Makino H,ORIENT study investigators.doi
10.1007/s00125-011-2325-zsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
2978-86issue
12eissn
0012-186Xissn
1432-0428journal_volume
54pub_type
杂志文章,多中心研究,随机对照试验相关文献
DIABETOLOGIA文献大全abstract::Recently, we described a leprechaun patient with a genetically transmitted severe insulin resistance due to the absence of functional insulin receptors as inferred from the loss of insulin binding to the patients' fibroblasts and the impaired autophosphorylation of the beta-chain of the receptor. This patient was homo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274534
更新日期:1989-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cel...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3341-6
更新日期:2014-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin resistance is linked with a cluster of multiple risk factors and excessive acceleration of atherosclerosis. The underlying mechanism is not, however, fully understood. METHODS:To determine the link between insulin resistance and altered vascular function, we focused on the effect of various non...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051668
更新日期:2001-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100595
更新日期:2001-08-01 00:00:00
abstract::An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281308
更新日期:1982-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0992-1
更新日期:2008-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4222-6
更新日期:2017-05-01 00:00:00
abstract::The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00260950
更新日期:1982-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mild cognitive dysfunction is not uncommon in adults with Type 1 diabetes, but its pathogenesis remains unclear. Previous cross-sectional studies had suggested that microangiopathy might affect brain integrity and lead to "central neuropathy." To assess the relationship between changes in cognitive perf...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1128-2
更新日期:2003-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2193-6
更新日期:2011-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Low birthweight (LBW) is associated with dysfunctions of adipose tissue and metabolic disease in adult life. We hypothesised that altered epigenetic and transcriptional regulation of adipose-derived stem cells (ADSCs) could play a role in programming adipose tissue dysfunction in LBW individuals. METHO...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4099-9
更新日期:2016-12-01 00:00:00
abstract::Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, rece...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-015-3844-9
更新日期:2016-03-01 00:00:00
abstract:AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2595-0
更新日期:2012-09-01 00:00:00
abstract::A double HbA1c-band was demonstrated in isoelectric focussing of blood from diabetics with a fasting blood glucose above 11 mmol/l. The same band-doubling was also demonstrated after incubation of erythrocytes in glucose/saline solutions. This finding may reflect the presence of the initial condensation product betwee...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281827
更新日期:1980-11-01 00:00:00
abstract::Present-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, ther...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05367-2
更新日期:2021-01-16 00:00:00
abstract:AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4082-5
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05338-7
更新日期:2021-01-06 00:00:00
abstract:AIMS/HYPOTHESIS:Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations. No studies to date have investig...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0919-1
更新日期:2002-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1837-2
更新日期:2010-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1), a polypeptide hormone secreted by the l-cells in the gastrointestinal tract, has shown promising effects as a new treatment modality for patients with Type II (non-insulin-dependent) diabetes mellitus. However, the pharmacokinetic profile of native GLP-1 with a rapid eli...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00125-001-0719-z
更新日期:2002-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4086-1
更新日期:2016-12-01 00:00:00
abstract::Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282238
更新日期:1985-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1811-6
更新日期:2005-08-01 00:00:00
abstract::Subjects selected from a centre specializing in diabetes detection have been classified using nine different methods of diagnosis including the recent criteria of the National Diabetes Data Group and the World Health Organization. The applicability of these two new criteria have been evaluated and compared with seven ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00297390
更新日期:1983-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Adipose tissue expresses some bioactive molecules, which may be involved in the development of obesity-associated metabolic disorders and cardiovascular diseases. Vascular endothelial growth factor (VEGF) an important angiogenic factor is implicated in normal and pathological vessel formation. The aim o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1221-6
更新日期:2003-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2457-9
更新日期:2012-04-01 00:00:00
abstract::Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281298
更新日期:1982-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-011-2447-3
更新日期:2012-04-01 00:00:00
abstract::The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265369
更新日期:1988-12-01 00:00:00