Abstract：
AIMS/HYPOTHESIS:We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon response to insulin-induced hypoglycaemia (IIH) and a coincident loss of islet sympathetic nerves; (2) to determine whether invasive insulitis is required for this nerve loss; and (3) to determine whether sympathetically mediated glucagon responses are also impaired. METHODS:We measured glucagon responses to both IIH and tyramine in anaesthetised mice. We used immunohistochemistry to quantify islet sympathetic nerves and invasive insulitis. RESULTS:The glucagon response to IIH was markedly impaired in NOD mice after only 3 weeks of diabetes (change, -70%). Sympathetic nerve area within the islet was also markedly reduced at this time (change, -66%). This islet nerve loss was proportional to the degree of invasive insulitis. More importantly, blocking the infiltration prevented the nerve loss. Mice with autoimmune diabetes had an impaired glucagon response to sympathetic nerve activation, whereas those with non-autoimmune diabetes did not. CONCLUSIONS/INTERPRETATION:The invasive insulitis seen in diabetic NOD mice causes early sympathetic islet neuropathy. Further studies are needed to confirm that early sympathetic islet neuropathy is responsible for the impaired glucagon response to tyramine.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Taborsky GJ Jr,Mei Q,Hackney DJ,Figlewicz DP,LeBoeuf R,Mundinger TOdoi
10.1007/s00125-009-1494-5subject
Has Abstractpub_date
2009-12-01 00:00:00pages
2602-11issue
12eissn
0012-186Xissn
1432-0428journal_volume
52pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：:The effect of endogenous hyperinsulinaemia, produced by syngeneic transplantation of rat insulinoma at an extrapancreatic site, on pancreatic insulin and pancreatic polypeptide has been examined by radioimmunoassay and immunohistochemistry. Twenty days after subcutaneous transplantation, tumour-bearing rats exhibited ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00273864
更新日期：1985-03-01 00:00:00
abstract：:Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00452070
更新日期：1986-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究
doi：10.1007/s00125-004-1628-8
更新日期：2005-02-01 00:00:00
abstract：:Arterial hypertension and poor glycaemic control are central to the development of microalbuminuria in insulin-dependent diabetes mellitus (IDDM). Recent consensus has established sensitive criteria for their detection and treatment, although the proportion of patients who may benefit is unclear. Between 1988 and 1990...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400465
更新日期：1994-10-01 00:00:00
abstract：:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00422820
更新日期：1975-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also re...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-002-0833-6
更新日期：2002-06-01 00:00:00
abstract：:Major histocompatibility complex-linked immune response genes are thought to influence susceptibility to induction of both human insulin-dependent diabetes and murine streptozotocin-induced diabetes. To clarify this relationship, we administered streptozotocin intravenously in two doses (120 and 240 mg/kg body weight)...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00275678
更新日期：1984-07-01 00:00:00
abstract：:Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for...
journal_title：Diabetologia
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4190-2
更新日期：2017-03-01 00:00:00
abstract：:To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00420978
更新日期：1976-08-01 00:00:00
abstract：AIMS/HYPOTHESIS:Subtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of developing diabetes. Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in G...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3294-9
更新日期：2014-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cel...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3341-6
更新日期：2014-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-2864-6
更新日期：2013-05-01 00:00:00
abstract：:Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other i...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-019-04975-x
更新日期：2019-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3163-6
更新日期：2014-04-01 00:00:00
abstract：:Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-009-1420-x
更新日期：2009-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0885-8
更新日期：2008-02-01 00:00:00
abstract：:The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00280517
更新日期：1980-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Despite the overlap in occurrence of cardiovascular disease (CVD) and type 2 diabetes and their risk factors, family history of these diseases has not yet been investigated simultaneously in relation to cardiometabolic markers in offspring. We examined how a family history of CVD and/or diabetes relates...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-3988-2
更新日期：2016-08-01 00:00:00
abstract：:Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...
journal_title：Diabetologia
pub_type： 评论,杂志文章
doi：10.1007/s00125-013-3159-7
更新日期：2014-04-01 00:00:00
abstract：:Glucagon-like peptide-1 and glucagon-like peptide-2 are encoded by the m-RNA of pancreatic preproglucagon. They show high conservation in different species and substantial sequence homology to glucagon. Because no definite biological activity of these peptides has been reported, we investigated the effect of synthetic...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00291980
更新日期：1985-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2674-2
更新日期：2012-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00125-007-0911-x
更新日期：2008-03-01 00:00:00
abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00401840
更新日期：1995-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin resistance, we have performed a detailed time-course study in mice fed a high-fat diet (HFD). MET...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-2913-1
更新日期：2013-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-020-05305-2
更新日期：2021-01-01 00:00:00
abstract：:Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/s00125-002-0975-6
更新日期：2002-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:Diabetic distal symmetrical sensory polyneuropathy (DSP) affects 20-30% of diabetic patients. Transcutaneous electrical nerve stimulation (TENS) and electrical spinal cord stimulation have been proposed as physical therapies. We performed a controlled, randomised pilot trial to compare the effects of hi...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00125-005-1728-0
更新日期：2005-05-01 00:00:00
abstract：:Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00284462
更新日期：1983-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2457-9
更新日期：2012-04-01 00:00:00
