Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation.

abstract：AIMS/HYPOTHESIS:Mitochondria-associated endoplasmic reticulum membranes (MAMs) are regions of the endoplasmic reticulum (ER) tethered to mitochondria and controlling calcium (Ca(2+)) transfer between both organelles through the complex formed between the voltage-dependent anion channel, glucose-regulated protein 75 and...

journal_title：Diabetologia

authors： Rieusset J,Fauconnier J,Paillard M,Belaidi E,Tubbs E,Chauvin MA,Durand A,Bravard A,Teixeira G,Bartosch B,Michelet M,Theurey P,Vial G,Demion M,Blond E,Zoulim F,Gomez L,Vidal H,Lacampagne A,Ovize M

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...

journal_title：Diabetologia

authors： Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

更新日期：2010-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...

journal_title：Diabetologia

authors： Rees MG,Wincovitch S,Schultz J,Waterstradt R,Beer NL,Baltrusch S,Collins FS,Gloyn AL

更新日期：2012-01-01 00:00:00

abstract：:Several thrombogenic abnormalities are associated with diabetes. To investigate the underlying molecular mechanisms, we examined the effects of advanced glycation endproducts (AGE), non-enzymatically glycated protein derivatives, on the production of prostacyclin (PGI2), an anti-thrombogenic prostanoid, and of plasmin...

journal_title：Diabetologia

authors： Yamagishi S,Fujimori H,Yonekura H,Yamamoto Y,Yamamoto H

更新日期：1998-12-01 00:00:00

abstract：:Plasma insulin, intact proinsulin and 32-33 split proinsulin measured by specific immunoradiometric assays and insulin and C-peptide measured by radioimmunoassay were measured during a constant infusion of glucose test in ten diet-treated subjects with a history of Type 2 (non-insulin-dependent) diabetes (termed diabe...

journal_title：Diabetologia

authors： Clark PM,Levy JC,Cox L,Burnett M,Turner RC,Hales CN

更新日期：1992-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. METHODS:The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the Natio...

journal_title：Diabetologia

authors： Huo L,Shaw JE,Wong E,Harding JL,Peeters A,Magliano DJ

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

journal_title：Diabetologia

authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

更新日期：2004-04-01 00:00:00

abstract：:Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238 +/- 0.005 min-1 ...

journal_title：Diabetologia

authors： Asano T,Sasaki H,Okumura M

更新日期：1978-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...

journal_title：Diabetologia

authors： Olaiya MT,Knowler WC,Sinha M,Kobes S,Nelson RG,Baier LJ,Muller YL,Hanson RL

更新日期：2020-09-01 00:00:00

abstract：:Thiazolidinediones are potent antidiabetic compounds, which act by enhancing peripheral insulin sensitivity. They are also activators of the peroxisome proliferator activated receptor gamma in adipose tissue. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat and hence the capacity of...

journal_title：Diabetologia

authors： Hallakou S,Foufelle F,Doaré L,Kergoat M,Ferré P

更新日期：1998-08-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：:The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...

journal_title：Diabetologia

authors： Gouédard HA,Ménez JF,Meskar A,Caroff J,Lucas D,Legendre JM

更新日期：1984-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...

journal_title：Diabetologia

authors： Medina A,Parween S,Ullsten S,Vishnu N,Siu YT,Quach M,Bennet H,Balhuizen A,Åkesson L,Wierup N,Carlsson PO,Ahlgren U,Lernmark Å,Fex M

更新日期：2018-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. METHODS:Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean ± SEM BMI 33.3 ± 1.4 kg/m(2)), individuals with type 2 ...

journal_title：Diabetologia

authors： Bergman BC,Hunerdosse DM,Kerege A,Playdon MC,Perreault L

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

journal_title：Diabetologia

authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

更新日期：2021-01-23 00:00:00

abstract：AIMS/HYPOTHESIS:Chronic hyperglycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus often leads to a decline in glucose-responsive insulin secretion from pancreatic beta cells, a phenomenon called glucose toxicity. Upon hyperglycaemia, glycation reaction occurs in the beta cells and induces oxidat...

journal_title：Diabetologia

authors： Kajimoto Y,Matsuoka T,Kaneto H,Watada H,Fujitani Y,Kishimoto M,Sakamoto K,Matsuhisa M,Kawamori R,Yamasaki Y,Hori M

更新日期：1999-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...

journal_title：Diabetologia

authors： Taverna MJ,Sola A,Guyot-Argenton C,Pacher N,Bruzzo F,Slama G,Reach G,Selam JL

更新日期：2002-03-01 00:00:00

abstract：:Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose metabolism were decreased in hearts of 15-week-old obese rats when compared to lean age-matched controls. Basa...

journal_title：Diabetologia

authors： Zaninetti D,Crettaz M,Jeanrenaud B

更新日期：1983-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...

journal_title：Diabetologia

authors： Nesca V,Guay C,Jacovetti C,Menoud V,Peyot ML,Laybutt DR,Prentki M,Regazzi R

更新日期：2013-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...

journal_title：Diabetologia

authors： Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

更新日期：2019-05-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...

journal_title：Diabetologia

authors： Decanini A,Karunadharma PR,Nordgaard CL,Feng X,Olsen TW,Ferrington DA

更新日期：2008-06-01 00:00:00

abstract：:The incidence, prevalence, and ages and dates of onset of diabetes, were studied in 184 families with 2 or more affected children. Results suggested that the siblings of children who developed diabetes before the age of 16 years were 26 times more likely to develop diabetes than other children. Of all siblings surveye...

journal_title：Diabetologia

authors： Gamble DR

更新日期：1980-10-01 00:00:00

abstract：:We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...

journal_title：Diabetologia

authors： Green A,Hougaard P

更新日期：1983-09-01 00:00:00

abstract：:Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...

journal_title：Diabetologia

authors： Del Prato S,Enzi G,Vigili de Kreutzenberg S,Lisato G,Riccio A,Maifreni L,Iori E,Zurlo F,Sergi G,Tiengo A

更新日期：1990-04-01 00:00:00

abstract：:We have investigated whether and how the elevated glucose concentrations characteristic of diabetes may alter the interaction of endothelial cells with low-density lipoproteins (LDL). Protracted exposure of cultured human endothelial cells to 20 mmol/l glucose failed to affect either the relationship between the degre...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Markey B,Henriksen T,Witztum JL,Sampietro T

更新日期：1984-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined in skeletal muscle (1) whether fatty acid transport protein (FATP) 1 channels long-chain fatty acid (LCFA) to specific metabolic fates in rats; and (2) whether FATP1-mediated increases in LCFA uptake exacerbate the development of diet-induced insulin resistance in mice. We also examined whet...

journal_title：Diabetologia

authors： Holloway GP,Chou CJ,Lally J,Stellingwerff T,Maher AC,Gavrilova O,Haluzik M,Alkhateeb H,Reitman ML,Bonen A

更新日期：2011-06-01 00:00:00

abstract：:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...

journal_title：Diabetologia

authors： Hart WM,Espinosa C,Rovira J

更新日期：1997-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...

journal_title：Diabetologia

authors： Chowdhury A,Dyachok O,Tengholm A,Sandler S,Bergsten P

更新日期：2013-07-01 00:00:00